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GlossaryHair Follicle Damage (Follicular Damage)

injury to structures responsible for hair growth, causing hair loss

Hair Follicle Damage, also known as Follicular Damage, refers to the harm or injury sustained by the hair follicles, which are the small structures in the skin responsible for hair growth. This damage can result from various factors such as physical trauma, chemical exposure, infections, or autoimmune conditions like alopecia areata. When hair follicles are damaged, it can lead to hair thinning, hair loss, or even permanent baldness if the follicles are severely affected.

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community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community For those who switched from finasteride to Dutasteride !

in Chat 43 upvotes 10 months ago

People discussed switching from finasteride to dutasteride for hair loss treatment. They reported satisfaction with dutasteride, noting it was more effective than finasteride, particularly after finasteride's effects diminished, and some experienced additional benefits like cost savings and stabilized hair loss, rating dutasteride highly as a treatment.

community Quit vaping/smoking = 80% less loss

in Research/Science 235 upvotes 8 months ago

Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

community New hack? Tretinoin enhances minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes

in Research/Science 17 upvotes 2 years ago

The conversation discusses how Tretinoin may improve the effectiveness of Minoxidil for treating hair loss by increasing the activity of certain enzymes in hair follicles. One user comments that this information is not new.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community Month 5 – Fin, min, microneedling 1x month.

in Progress Pictures 70 upvotes 1 year ago

User made progress with hair loss using Fin, Min, and microneedling. Experienced side effects like improved skin, brain fog, and memory issues, but adjusting Fin dosage helped.

community 2 month of Finastrade 1.25 mg every day/minoxidil 5% twice a day/dermaroller .7 mm twice a week. Is there is any hope for the bald spaces to grow back

in Progress Pictures 99 upvotes 2 years ago

A user's progress pictures after taking finasteride, minoxidil and dermaroller treatments for hair loss over the past two months. Other users replied to offer advice and support on whether there is hope for hair regrowth.

community Dental technician is convinced that he has found the cause of pattern hair loss

in Research/Science 317 upvotes 4 months ago

A dental technician claims malocclusion causes pattern hair loss due to poor scalp circulation. Users debate this, noting treatments like finasteride, minoxidil, and microneedling focus on DHT and blood flow.

community How is it possible for someone to be a non responder to ORAL minoxidil?

in Minoxidil 66 upvotes 8 months ago

Some individuals do not respond to oral minoxidil for hair loss, despite it generally working by improving blood flow to hair follicles. Factors like metabolism, drug interactions, and individual variations in the drug's activation may influence its effectiveness.

community Interesting article links major MPB theories to western diet (and life-style)

in Research/Science 55 upvotes 1 month ago

Poor diet and lifestyle contribute to male pattern baldness. Treatments like Minoxidil, dietary changes, and lifestyle adjustments may help slow hair loss.

community Cure/better treatment options in the future

in Chat 11 upvotes 4 months ago

The conversation is about future hair loss treatments. Current treatments mentioned include finasteride, minoxidil, and RU58841, with potential future treatments like GT20029, TDM-105795, JW0061, and follicle cloning.

community Microneedling technique clarification

in Microneedling 16 upvotes 5 months ago

The conversation is about using a Dr. Pen for microneedling on a widow's peak, with advice to use a depth of 1.25mm and hold it in place for 10 seconds. The user is also using minoxidil.

community 10 Days Post-Op: Hair Transplant Results and Experience

in Progress Pictures 508 upvotes 6 months ago

A user shared their positive experience with a hair transplant at Dr. Resul Yaman Hair Clinic in Istanbul, including before and after photos. They are considering taking oral Minoxidil post-operation but are avoiding Finasteride due to side effects.

community Is hair thinning or loss associated with pain?

in Research/Science 6 upvotes 1 year ago

Hair thinning/loss associated with burning scalp pain. Finasteride helped relieve "DHT itch" for one person.

community Can someone explain the science behind why Finasteride doesn't stop you from losing regrown hairs from minoxidil?

in Minoxidil 100 upvotes 3 weeks ago

Finasteride prevents further hair loss by blocking DHT, while minoxidil stimulates hair growth by prolonging the active phase of hair follicles. Stopping minoxidil can lead to loss of regrown hair because finasteride does not address the same growth mechanism.

community Insane MTF recovery 18 months blocking androgens

in Progress Pictures 145 upvotes 1 year ago

Hair loss recovery using estrogen and anti-androgen treatment for 18 months showed significant improvement. However, results vary and alternative treatments like RU58841 and Dutasteride may work without systemic feminization.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 743 upvotes 2 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

in Research/Science 101 upvotes 2 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.

community DIY treatment... Shedding completely stopped after 1.5 yrs

in Treatment 249 upvotes 2 years ago

Vitamin C mixed with shampoo stopped shedding and promoted hair regrowth after 1.5 years. Both the person and their wife experienced significant hair loss reduction with this method.

community About 9 Months on Topical Fin/Min

in Progress Pictures 585 upvotes 3 years ago

User shares 9-month progress using topical Fin/Min formula (10% Min, 0.1% Fin) for hair loss, with significant improvement in crown area. Others discuss experiences, side effects, and application methods for the treatment.

community 12 mo 1 ml daily Min/Dermaroller 1mm-1.5mm update + AGA progression theory and specific order of treatment

in Microneedling 15 upvotes 3 years ago

A user shared their year-long hair loss treatment using minoxidil, microneedling, and scalp massages, reporting moderate hair growth and stabilization. They suggest starting early with less harmful methods and consider adding finasteride or dutasteride if needed.

community It’s crazy how it’s 2018 and the only hair loss treatments we have feature undesirable side effects and/or aren’t even effective for many people.

136 upvotes 6 years ago

Hair loss treatments, including minoxidil, dermarolling, finasteride, dutasteride, hair transplants, hair systems, and shaving the head. The conversation covers various opinions on these treatments and mentions possible side effects as well as alternatives like wigs, vitamins, and lifestyle changes. The post expresses disappointment that there has been no major breakthrough in the field of hair loss treatments despite decades of research.

community We need more people trying 2.5 mg dutasteride

in Finasteride/Dutasteride 2 upvotes 1 month ago

Increasing the dutasteride dose to 2.5 mg may significantly reduce DHT and promote hair regrowth, with similar side effects to lower doses. Some users combine dutasteride with minoxidil and finasteride for better results, but there are concerns about long-term effectiveness and availability.

community Why is Minoxidil not enough for hair loss? (No fin)

in Minoxidil 57 upvotes 1 week ago

Minoxidil alone is often insufficient for treating hair loss because it doesn't address the DHT-related cause. Combining it with finasteride, a DHT blocker, is generally more effective.

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

in Research/Science 1 upvotes 2 weeks ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

in Research 413 upvotes 2 weeks ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

community 4600 FUT Hair Transplant 16 month post second surgery progress

in Transplants 3670 upvotes 1 month ago

The user had two FUT hair transplants with 4,600 grafts for increased density, costing about $11,000 each, and has been using oral minoxidil and finasteride for over five years without side effects. The results are natural-looking with no visible scarring, and the user finds the procedure valuable despite the cost.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 2 months ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community Finasteride 4 months way worse then when I started, shed or am I cooked? 19m

in Progress Pictures 169 upvotes 3 months ago

A 19-year-old experienced worsening hair loss after 4 months on finasteride, despite initial improvement with minoxidil. The consensus is to continue treatment for at least a year, as shedding is common and often temporary.

community After 11 Years On Finasteride, Unfortunately, Hair Is Starting To Thin Again. Does Hair Simply Get More Sensitive To DHT As You Age?

in Finasteride/Dutasteride 95 upvotes 7 months ago

After 11 years on Finasteride, a user's hair is thinning again, suggesting hair may become more sensitive to DHT with age. They plan to introduce Dutasteride once a week, as they cannot tolerate Minoxidil.