Hair growth can be induced without stopping DHT, as seen with Minoxidil. HMI115 may work by promoting follicle growth, not targeting the root cause of hair loss (DHT).
The discussion revolves around the need for future oral DHT blockers for hair loss treatment that don't have the side effects of current options like Finasteride and Dutasteride. One user suggests that the future of hair loss treatment will likely be topical anti-androgens, as they can target hair follicles without affecting the entire system.
A user expressed frustration with hair loss treatments, including finasteride, minoxidil with micro-needling, and RU58841, which all failed to stop hair thinning and miniaturization. Suggestions from others included accepting baldness, considering hair systems, and continuing prescribed antidepressants for depression.
The conversation is about the effectiveness of Dutasteride (Dut) and Minoxidil (Min) in reversing hair thinning. The user has been using Dut for 3 months and Min for a couple of years, and while hair fall has reduced, thinning continues. Other users suggest that Dut can reverse hair thinning over time, possibly beyond a year, and the outcome depends on individual body reactions and the degree of hair miniaturization.
A user's extreme regimen for hair loss, which includes taking oral and topical medications such as minoxidil, dutasteride, cyproterone acetate and bicalutamide, but still experiencing miniaturization. Suggestions were made to try other treatments such as RU58841 and Pyrilutamide, while also considering mental health treatment and advice on lookmaxxing.
The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.
Testosterone within the normal range does not significantly contribute to male pattern baldness (MPB); DHT is the main factor that can be controlled. Genetics play a crucial role in hair loss, and treatments like finasteride and dutasteride, which block DHT, can help despite potentially raising testosterone levels.
A user's progress with hair loss treatment, which includes taking finasteride pills and using minoxidil once daily; discussing the effects of these treatments and the experience of shedding and regrowth; and advice on adding microneedling.
The conversation discusses affordable hair loss treatments, including topical finasteride, minoxidil, tretinoin, and natural remedies like castor and peppermint oil. Specific treatments for hair loss are the focus.
Minoxidil alone may not stop hair loss. Finasteride is recommended for androgenic alopecia, as minoxidil doesn't prevent DHT from miniaturizing hair follicles.
A user had a bad reaction to Finasteride, experiencing anxiety and fatigue, and is seeking alternative hair loss treatments since they can't use Finasteride or Minoxidil. Suggestions include trying low doses of Finasteride, making a topical version, or using other treatments like Alfatradiol, but the user is hesitant to use Finasteride again and is considering a hair transplant.
A 57-year-old man with severe hair loss since age 14 tried various hair loss treatments over two years, including finasteride, dutasteride, minoxidil, and supplements, with some minor regrowth. He also experimented with topical treatments and microneedling, but results were not cosmetically significant.
HairClone is developing cell replacement treatments to rejuvenate and generate hair follicles, and has launched a crowdfunding campaign. A user expressed skepticism about the need for crowdfunding.
The user experienced hair regrowth and strengthening using finasteride, minoxidil, micro-needling, Nizoral, and biotin products. Despite progress, they acknowledge that a hair transplant may be needed for full hairline restoration.
The user is experiencing hair thinning despite using Dutasteride and Finasteride and is considering adding Minoxidil. Suggestions include increasing the Dutasteride dose, checking for health issues, and considering a hair transplant.
Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.
OP believes RU58841 affected their thyroid, causing hypothyroidism and impacting minoxidil's effectiveness. They plan to start thyroid medication to improve hair regrowth.
A user reports hair regrowth and thickening after 3.5 months using oral dutasteride (0.5mg) and oral minoxidil (5mg). They express gratitude for the information received from the community about hair loss treatments.
The user is one month into their FUE treatment and has just undergone PRP treatment at American Mane in Miami. They plan to start using minoxidil and LLT, take xpecia with saw palmetto, and try Exosome from ExoScrt and PRP for better hair growth results.
A user who has been using Pyrilutamide for 5 months with no results, and other users suggesting they switch to RU58841 or stick to their treatment plan for at least one year.
Hair loss in a 3-year-old, with various treatments discussed such as minoxidil, finasteride, dutasteride, RU58841 and biotin supplementation. Some people suggested shaving the head and growing a beard or getting a partial hairpiece instead of attempting to treat it.
A 21-year-old MTF individual is experiencing rapid hair thinning and is currently on estradiol valerate. They are inquiring about the effectiveness of spironolactone for hair loss, despite being aware of its serious side effects.
A user who got a hair transplant and gave their experience with it, including how the donor area recovered quickly and the potential risks of getting a hair transplant at a young age. Other users discussed bleaching and dyeing transplanted hair, as well as asking about the clinic where the procedure was done.
User on oral dutasteride and minoxidil for a year experienced slowed hair loss and regrowth initially, but now rapidly thinning again. Asks if adding fluridil to the regimen would be enough to stop hair loss.
The conversation discusses the complexity of hair loss causes, suggesting that DHT sensitivity alone doesn't fully explain it. Treatments mentioned include finasteride and dutasteride.
The conversation discusses the effectiveness of finasteride and dutasteride for hair loss, with some users finding no improvement and experiencing side effects. It also mentions the use of RU58841 and topical minoxidil, highlighting that hair sensitivity to DHT varies among individuals.
Dutasteride, especially at higher doses, is considered more effective than Minoxidil for hair regrowth by blocking DHT, which causes hair loss. Combining Dutasteride with Minoxidil may enhance hair recovery by prolonging the hair growth phase.
Finasteride prevents further hair loss by blocking DHT, while minoxidil stimulates hair growth by prolonging the active phase of hair follicles. Stopping minoxidil can lead to loss of regrown hair because finasteride does not address the same growth mechanism.
Dutasteride and finasteride can affect libido differently, with some experiencing increased libido and others decreased libido or erectile dysfunction. Dutasteride may increase testosterone levels but can also cause side effects like liver enzyme changes, while topical finasteride may have fewer sexual side effects.
If oral minoxidil 2.5mg and finasteride 1mg fail after a year, some suggest trying dutasteride. Hair shedding can be normal in the first year, and real changes often occur between 9 months to a year.