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      community Researchers working on ways to regenerate lost hair from stem cells identified a recipe for normal hair regeneration in the lab. “A method for cyclical regeneration of hair follicles from hair follicle stem cells and will help make hair follicle regeneration therapy a reality in the near future.”

       263 upvotes 5 years ago
      Hair loss treatments like finasteride, minoxidil, and hair transplants have side effects and limitations. There is hope for future advancements in stem cell therapy and hair follicle regeneration, though skepticism about their effectiveness and timeline persists.

      community Rational Review of Pelage Results

      in Chat  11 upvotes 1 year ago
      A treatment showed a 20% hair density increase in weeks, with nearly a third of participants experiencing significant results, while questions remain about its long-term efficacy and effectiveness across different scalp areas. There is interest in combining it with finasteride and minoxidil for potentially better outcomes.

      community Pp405 - lowkey kinda bad results

       18 upvotes 1 year ago
      PP405 increased hair density by 20% in 31% of participants, but results are considered underwhelming. Minoxidil and finasteride are seen as more effective treatments.

      community Dht kills hair, but no one says why?

      in Finasteride/Dutasteride  40 upvotes 1 year ago
      DHT affects hair follicles, contributing to hair loss, but the exact mechanism is unclear. Treatments like finasteride and minoxidil are used to manage hair loss, though they may have side effects and varying effectiveness.

      community New molecule PP405 vs exercise

       36 upvotes 1 year ago
      PP405 targets hair follicle stem cells differently than exercise-induced lactate, suggesting exercise alone may not replicate its benefits. Minoxidil and finasteride are recommended alongside exercise for hair regrowth, with additional suggestions like spicy food and infrared exposure.

      community Could RU58841 actually worsen hairloss?

      in Treatment  2 upvotes 1 year ago
      The user experienced worsening hair density after using finasteride, dutasteride, and RU58841, suspecting RU58841 might be the cause. They are considering stopping RU58841 after a scalp biopsy, while others share mixed experiences with RU58841's effectiveness.

      community For people that keep saying Breezula is weaker than fin...

       6 upvotes 6 years ago
      Breezula protects hair follicles from both testosterone and DHT, unlike finasteride, which only protects against DHT. This could potentially lead to significant hair regrowth, similar to results seen in transgender individuals using hormone blockers.

      community Update and new paper from Dr tsuji

       26 upvotes 7 years ago
      Hair follicle regenerative therapy is being developed, with clinical trials planned in Japan, potentially allowing for hair cloning and eliminating the need for treatments like finasteride. If successful, the treatment could be available in Japan by 2025, but widespread access and affordability may take longer.

      community 3/9/26 to 7/5/26 results - Oral Min + Fin + GHK-Cu (SubQ)

       61 upvotes 2 months ago
      The user reported positive results in hair density and skin improvement using a combination of oral Minoxidil, Finasteride, and subcutaneous GHK-Cu. They experienced less shedding with oral Minoxidil compared to topical and noted significant skin benefits from GHK-Cu.

      community Before and after: 1 year of Min, 8 months of Fin

       355 upvotes 4 months ago
      Improved hair density and texture after using 1mg oral finasteride and 5mg oral minoxidil for a year. The user is satisfied with the results, noting no significant side effects except reduced seminal volume.

      community When results are great, but you're looking for excellent

      in Chat  3 upvotes 7 months ago
      The user improved hair density from 45% to 70% using dutasteride and minoxidil, but still uses hair fibers for a fuller look. They added a topical mix of minoxidil, finasteride, and bimatoprost, but doubt further significant improvement.

      community Does Tretinoin work? Can somebody share their experience

       2 upvotes 7 months ago
      Tretinoin can increase hair follicles and is used alongside minoxidil and finasteride for hair growth, though it may cause skin peeling. Users report varying results, with some experiencing regrowth and others questioning its efficacy for hair.

      community How does testosterone and dht work?

       14 upvotes 1 month ago
      Hair loss is influenced by follicle sensitivity to DHT, which increases with age, rather than just testosterone levels. Treatments like finasteride and hair transplants are used to manage hair loss, with transplants needing medication to protect surrounding sensitive hair.

      community Why PP405 may not be dead just yet

       1 upvotes 1 month ago
      PP405 shows promise in reactivating dormant hair follicles, with early trials indicating some success, but it is not yet a proven treatment for hair loss. Users are advised to be cautious with unverified versions, and further research is needed to confirm its effectiveness compared to treatments like minoxidil and finasteride.

      community Why do Hair Transplant procedures take a rectangle from the donated area?

      in Transplants  6 upvotes 1 month ago
      Hair transplants typically involve spreading follicle extraction across the back and sides of the head to maintain an even appearance, rather than taking a solid rectangle of grafts. FUT procedures, which involve taking a strip of skin, are less common now due to advancements in techniques like FUE, which heal well and are less invasive.

      community Highly recommend buying a microscope (see pictures)

      in Treatment  44 upvotes 8 months ago
      A user recommends using a microscope to assess hair density and track hair loss progress, finding it useful for evaluating treatment effectiveness, particularly with dutasteride and minoxidil. They advise against obsessing over hair loss and emphasize focusing on other meaningful life aspects.

      community Quote from Pelage (PP-405) Spokesperson...

       122 upvotes 11 months ago
      Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.

      community New Hair Loss Treatment: Adipose Derived Secretomes

       18 upvotes 1 year ago
      Adipose-derived stem cell secretome showed significant improvement in hair density and growth, especially when combined with minoxidil, suggesting a synergistic effect. The study had limitations, including a small sample size and potential bias.

      community 4600 FUT Hair Transplant 16 month post second surgery progress

      in Transplants  3725 upvotes 1 year ago
      The user had two FUT hair transplants with 4,600 grafts for increased density, costing about $11,000 each, and has been using oral minoxidil and finasteride for over five years without side effects. The results are natural-looking with no visible scarring, and the user finds the procedure valuable despite the cost.

      community It’s all about the stem cells…

       53 upvotes 4 years ago
      Hair loss is linked to the loss of stem cells in hair follicles, and potential treatments include gene editing and microneedling. Discussions also mention using Minoxidil, finasteride, and dermarolling to improve hair growth.

      community Topical melatonin shows some promise.

       4 upvotes 10 years ago
      Topical melatonin shows promise for increasing hair density with minimal side effects. The user is transitioning from oral finasteride to a compounded minoxidil and finasteride solution and considering melatonin and bimatoprost as additional treatments.

      community Secondary shedding, 6 months into oral minoxidil/finasteride 3mg chewables

       55 upvotes 4 months ago
      The user experienced significant hair regrowth and increased density after six months of using oral minoxidil and finasteride chewables, despite going through a secondary shedding phase. The only side effect mentioned was restlessness, and the user feels healthier overall.