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GlossaryEstrogen Receptor Alpha (ER-alpha)

protein inside cells that binds to estrogen hormone

Estrogen Receptor Alpha (ERα) is a protein found inside cells that binds to the hormone estrogen. This receptor is crucial for regulating various biological processes, including reproductive functions and the development of certain tissues. In the context of hair and alopecia, ERα can influence hair growth and loss, as estrogen plays a role in the hair growth cycle.

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community Mechanism of action of alfatradiol (17 alpha estradiol)

in Research/Science 6 upvotes 8 months ago

The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

community Update: Chest discomfort from RU58841

in Update 34 upvotes 1 year ago

A user experienced severe chest pains and shortness of breath after using RU58841 for hair loss and was advised by a doctor that blocking androgens can weaken the heart. They decided to continue with finasteride, minoxidil, and a hair transplant instead.

community Vitamin E

20 upvotes 6 years ago

Vitamin E was discussed as a treatment for hair shedding, with a specific form mentioned. A user shared a link to a study and started taking the Vitamin E variants used.

community Dutasteride takes 1-3 months to work in the scalp. Not weeks. Be careful.

in Finasteride/Dutasteride 41 upvotes 6 months ago

Dutasteride takes 1-3 months to affect scalp DHT levels, not just a week. The prostate absorbs Dutasteride faster than the scalp due to different vascular networks and enzyme densities.

community DHT/Testosterone levels in scalp Fin VS Dut.

in Finasteride/Dutasteride 66 upvotes 7 months ago

Dutasteride raises scalp testosterone by 99%, which may not be ideal for those sensitive to all androgens. Some argue finasteride's balancing act might be better, while others believe dutasteride is superior for hair regrowth.

community 10 months Fin 1mg & micro needling

in Progress Pictures 260 upvotes 7 months ago

A user shared their 10-month progress using 1mg finasteride daily and micro-needling, noting significant hair regrowth and no side effects. They plan to add oral minoxidil to boost hair density.

community Ashton Kutcher talked about on the tonight show how he was quitting dut. Looks like the Norwood reaper has already come to collect.

in Satire 623 upvotes 1 year ago

The conversation is about Ashton Kutcher's hairline and how some people think it looks good for his age, while others criticize it. Some mention that he used to use medication for hair loss but stopped.

community Why is Kevin Mann (Haircafe) Hated?

in Chat 62 upvotes 1 year ago

Hair loss treatments, including microneedling, minoxidil, finasteride and RU58841; the efficacy of these treatments; criticisms of Kevin Mann's content related to his selective data presentation and biases towards certain treatments; and other topics such as DHT being labeled a "trash hormone" and critiques of other hairloss YouTubers.

community Would there be ANY reason to still take 5AR inhibitors if pyrilutamide does what is intended?

in Research/Science 16 upvotes 2 years ago

A potential new treatment for hair loss, Pyrilutamide, and the discussion of whether or not people should still be taking traditional treatments like Minoxidil and Finasteride with it.

community Future hope ? What do you guys predict ? clascoterone, pyrilutamide, gt20029 etc.

in Treatment 15 upvotes 3 years ago

User tried oral finasteride, topical finasteride, topical dutasteride, and RU58841 but experienced side effects. They discuss upcoming treatments like clascoterone, pyrilutamide, gt20029, and KY19382 as potential options.

community Why is it that low testosterone causes hair loss as well? How can I be balding?

in Chat 158 upvotes 10 months ago

The conversation discusses the confusion over low testosterone potentially causing hair loss, with users sharing personal experiences and knowledge about hair loss treatments like Finasteride. Some users suggest that hair follicle sensitivity to DHT, not testosterone levels, is the key factor in balding, and others discuss the side effects of hair loss medications.

community Finasteride vs Dutasteride: The Science

in Research/Science 168 upvotes 1 year ago

The conversation compares Finasteride and Dutasteride for hair loss treatment, discussing their effectiveness and side effects. Users share personal results and consider combining treatments like Dutasteride with RU58841.

community Nothing's working, I feel depressed, also hopeless for the first time

in Update 104 upvotes 2 years ago

A user's experience with hair loss treatments, including Finasteride, Minoxidil, Nizoral Shampoo, Rosemary Oil, Vitamin D, Biotin, Vitamin C, Zinc and Dermarolling, that have not been successful over the past 14 months. Other users gave advice on how to cope with the issue, such as exercising, changing mindset, and shaving their head.

community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 2 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.

community Transient and Permanent Effects of Finasteride Use

in Research/Science 154 upvotes 3 years ago

Potential side effects of 5AR inhibitors like finasteride and dutasteride. Users debate risks, benefits, and personal experiences with these hair loss treatments.

community Are there a lot of young folks here on fin?

in Chat 1 year ago

Young people who have used finasteride and minoxidil to treat hair loss, with generally positive results reported by those taking the treatments.

community Extreme caution: my experience using Ru58841 only once

in Treatment 8 upvotes 1 month ago

An 18-year-old experienced severe side effects, including heart palpitations and high blood pressure, after using RU58841 once, leading to a referral to cardiology for suspected left ventricular hypertrophy. The user regrets using RU58841 and seeks advice on recovery, while others suggest preexisting conditions or genetic predispositions may be factors.

community DHT Isn't (Directly) Important

in Research/Science 100 upvotes 6 days ago

Finasteride's potential side effects, especially sexual dysfunction, are discussed, with emphasis on hormonal balance between testosterone and estradiol. Users share experiences with finasteride, minoxidil, and dutasteride, highlighting the variability in side effects and the influence of mindset and lifestyle.

community Finasteride weird side effects

in Finasteride 100 upvotes 2 weeks ago

The user experienced bladder and prostate discomfort after taking finasteride and stopped the medication, but symptoms returned upon resuming at a lower dose. The doctor suggested trying dutasteride as an alternative.

community Why the fu*k do people behave like this?

in Chat 385 upvotes 1 year ago

People making comments on others' hair loss, and the different strategies used to deal with it. Treatments mentioned include finasteride and minoxidil.

community Anyone here who’s using Alfatradiol (17a-Estradiol) in consistency with some results?

in Treatment 7 upvotes 3 years ago

User discusses Alfatradiol (17a-Estradiol) as a potential hair loss treatment with mixed results. Concerns include low dosage, receptor theory, and possible increased aromatase activity on scalp.

community 4 Months on Minoxidil Foam, 3 months on Redensyl (no longer using)

in Progress Pictures 11 upvotes 4 years ago

A 24 year old man suffering from male pattern baldness who has been using minoxidil foam and Redensyl (no longer using) for four months, resulting in general thickening of the hair with some regrowth. The user is also awaiting to get a Finasteride prescription and hormone panel done.

community Low-Dose Oral Minoxidil Does Not Significantly Affect BP

in Minoxidil 178 upvotes 3 months ago

Low-dose oral minoxidil is used for hair loss and does not significantly affect blood pressure but may increase heart rate and cause hypotensive symptoms. Some users experience side effects like palpitations and shortness of breath, while others find it effective; topical minoxidil with tretinoin is also considered.

community I am putting my hair loss treatment on hold until my mental health is better.

in Update 21 upvotes 5 months ago

OP is pausing hair loss treatments to focus on mental health due to anxiety and side effects from RU58841. They plan to try topical finasteride and minoxidil after recovering from pneumonia.

community Help in Germany to get recommended medicine

in Finasteride/Dutasteride 5 upvotes 6 months ago

A user in Germany is seeking advice on obtaining Dutasteride, Minoxidil, and Biotin for hair treatment before a hair transplant. They face difficulties getting prescriptions and are concerned about delays due to required exams.

community 6 months on fin 1mg everyday, good progress? (20M)

in Is this regrowth? 181 upvotes 7 months ago

A user shared their 6-month progress on finasteride but stopped due to financial issues, seeking advice on whether to continue. Replies strongly advised resuming finasteride to maintain progress, with suggestions for affordable options.

community Anyone know this Dut brand? Just got my prescription in EU

in Finasteride/Dutasteride 16 upvotes 8 months ago

A user received a prescription for Dutasteride 0.5 in Europe and asked about the brand. Replies confirmed the brand's quality and suggested using the cheapest gelatin capsule form.

community Just to show you the superiority of dutasteride over finasteride (it's huge)

in Research/Science 58 upvotes 8 months ago

Dutasteride is shown to be significantly more effective than finasteride for treating male androgenic alopecia. Users discuss the difficulty of obtaining dutasteride in some countries and share personal experiences with its effectiveness and side effects.

community Minoxidil Finasteride heart problems

in Update 97 upvotes 9 months ago

A user experienced heart problems after taking 1mg finasteride and 2.5mg oral minoxidil and is considering quitting minoxidil. Others discussed their experiences with heart issues and minoxidil, with some suggesting topical minoxidil as a safer alternative.

community Hair energiser tablets, useful or not?

in Product 11 months ago

A user is unsure if "Hair Energiser" tablets are effective for hair growth after a year of use. Replies suggest using finasteride instead and call the tablets a scam.