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GlossaryEntrapment Efficiency

percentage of substance successfully encapsulated within a carrier system

Entrapment Efficiency refers to the percentage of a substance, such as a drug or active ingredient, that is successfully encapsulated within a carrier system, like nanoparticles or liposomes, during the formulation process. For example, if you are trying to deliver a medication to treat hair loss, high entrapment efficiency means that most of the medication is effectively enclosed within the delivery system, ensuring it reaches the target area more effectively.

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community The story of RU58841/ PSK3841

Typical-Promise-3001 in Research 622 upvotes 5 months ago

RU58841, a potential hair loss treatment, was not commercialized due to marketability issues and lack of long-term safety data. Concerns about its formulation and delivery methods further complicate its use.

community 12M post-op +dutasteride daily / FUE 3000Hairs in Korea

CuriousTap4641 in Progress Pictures 526 upvotes 7 months ago

A user shared progress pictures 12 months after a hair transplant and daily use of dutasteride. The conversation discusses the quality of comparison photos and the use of hair fibers.

community Soundwaves & Electricity Grows Hair? | Peptide Delivery Model.

noeyys in Research/Science 2 upvotes 6 months ago

Iontophoresis and sonophoresis can enhance drug delivery into the scalp. Combining these methods may improve the effectiveness of topical treatments like dutasteride and certain peptides.

community Should I apply my grapefruit topically instead of injecting it into my bloodstream?

Plasma_2416 in Satire 74 upvotes 1 year ago

The conversation is a satirical discussion about using grapefruit for hair regrowth, with suggestions ranging from injecting it to applying it topically or anally. Some users claim unusual benefits like emitting a green aura or jumping high.

community 15 months on the Big 3! My journey so far…

No-Organization-2585 in Progress Pictures 162 upvotes 2 years ago

A user's progress after 15 months of using the "Big 3" treatments for hair loss (finasteride, minoxidil and micro needling) as well as Nizerol 2%. The post encourages others to seek out available information on hair loss treatment and reassures them that if it doesn't work, it is only hair.

community Fin/Dut and Metabolism Speeds…

Just_Presence_581 in Finasteride/Dutasteride 8 upvotes 5 months ago

A user speculates that a fast metabolism might affect the effectiveness of dutasteride for hair loss. Another user argues that drug response is unrelated to metabolism speed.

community “Dutasteride destroyed my hair” recently I noticed the same users

Professional_Oil2044 in Finasteride/Dutasteride 81 upvotes 5 months ago

Dutasteride is reported by some users to worsen hair loss, while others believe it causes shedding before improvement. Finasteride and Minoxidil are also mentioned as treatments, with mixed results.

community How is it possible for someone to be a non responder to ORAL minoxidil?

FlochTheDestroyeer in Minoxidil 66 upvotes 9 months ago

Some individuals do not respond to oral minoxidil for hair loss, despite it generally working by improving blood flow to hair follicles. Factors like metabolism, drug interactions, and individual variations in the drug's activation may influence its effectiveness.

community Keratin microspheres - breakthrough

KieronR101 in Research/Science 13 upvotes 11 months ago

A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

community Complete Guide to Orally Taking Topical Minoxidil

CumShotDiva in DANGEROUS / UNPROVEN 149 upvotes 2 years ago

Taking topical minoxidil orally for hair loss treatment, discussing safety, dosing, side effects, and FAQs. Users express concerns about safety and potential heart damage, while others share experiences and results.

community When is Breezula expected to be available for the public?

Lancadin in Question 28 upvotes 5 years ago

The conversation is about the availability of Breezula, a hair loss treatment, with speculation it might be released in 2022 or potentially never, as it's more effective than finasteride. No specific treatments were confirmed.

community New potential hair loss treatment (news release)

wrassman in Treatment 186 upvotes 4 years ago

New potential hair loss treatment uses molecules from hairy moles to stimulate follicle growth. Topical solution requires less frequent application, like Botox injections a few times per year.

community Oral Minoxidil and Grapefruit Juice

Typical_Platform105 in Research/Science 96 upvotes 1 year ago

The conversation is about the potential dangers of taking oral minoxidil and grapefruit juice together. Some users express concern about dangerous drug interactions, while others argue that grapefruit juice may inhibit the metabolism of finasteride. The conclusion is that grapefruit juice may make finasteride less effective, but it won't affect minoxidil.

community Wasn't Breezula supposed to post some results soon?

VanLaing84 in Question 18 upvotes 5 years ago

The conversation is about expecting results from Breezula, a hair loss treatment, with no new information released as of April 1st. Some joked it's just onion juice, while another comment suggested a conspiracy to cause baldness.

community about a year difference. i’m only 21 bruh

Leaking-flashlight in Progress Pictures 173 upvotes 7 months ago

A 21-year-old user shared progress pictures showing hair loss treatment results after using finasteride for a year and minoxidil for 6-7 months. Despite some improvement, the user is unhappy with hair density and hairline.

community What blood exams should I do on dut/oral min

Specialist_Soup_2289 in Chat 1 upvotes 7 months ago

The user checked iron, ferritin, B12, zinc, testosterone, DHT, and estrogens to understand hair loss causes and the effects of dutasteride. They also noted increased heart rate and paleness with oral minoxidil.

community Who said GT20029 would be applied only few times per month?

Working-Tradition546 in Research/Science 10 upvotes 2 years ago

The conversation discusses the safety and effectiveness of a hair loss drug, GT20029, and the possibility of infrequent application, with users hoping for once-daily use and speculating on the drug's duration of effect on the scalp. Specific treatments mentioned include Minoxidil, finasteride, and RU58841.

community New drug for hair loss announced by Amplifica

wrassman in Research/Science 161 upvotes 2 years ago

Amplifica starting clinical trials for new hair loss drug. SCUBE3 protein discovered, stimulates hair growth, could be alternative to Minoxidil and Finasteride.

community Does microneedling regrow hair on dormant bald regions which have been bald for many years?

vinsmokeXD in Microneedling 6 upvotes 4 years ago

Microneedling may help regrow hair in dormant bald regions by stimulating stem cell transfer. Users discuss its effectiveness and how collagen might aid in the process.

community Can Pyrilutamide use stopp Minoxidil gains

More-Ad-3194 in Chat 3 upvotes 10 months ago

The conversation discusses whether using pyrilutamide would interfere with minoxidil's ability to regrow hair, considering pyrilutamide is seen as a maintenance drug that stops shedding, while minoxidil promotes hair growth but causes initial shedding.

community Kintor Pharma Announces Completion of Subject Enrollment in Phase III Clinical Trial of KX-826 for Treatment of Male Androgenetic Alopecia

SleeperAgent2023 in Research/Science 80 upvotes 1 year ago

Kintor Pharma completed enrolling subjects for a Phase III trial of KX-826 for male hair loss treatment. The trial includes a 24-week treatment period and a 4-week safety follow-up, with results expected in about 6-7 months.

community Anageninc no longer sell KX-826 (Pyrilutamide) due to receiving a cease and desist letter from Kintor :(

Super_Eye_407 in Update 18 upvotes 1 year ago

Hair loss treatments discussed include Minoxidil, Finasteride, and RU58841. Anageninc stopped selling KX-826 (Pyrilutamide) due to a cease and desist letter from Kintor, but this may indicate promising study results and a potential 2024 release.

community About GT20029's Efficacy and Strength

onurtherebel in Chat 8 upvotes 1 year ago

The conversation is about the effectiveness and production of GT20029, a drug being developed as a topical androgen receptor degrader for hair loss, and whether it can fully degrade androgen receptors or only partially. It also discusses the drug's potential unique working mechanism and synthesis by a company called Anagen.

community Breezula will hit the market in 2026, Cosmo Pharmaceuticals statement!

Particular_Hunter844 in Product 53 upvotes 10 months ago

Breezula, a hair loss treatment, is expected to cost around $100 a month and is anticipated to be released in 2026. The effectiveness of Breezula is debated, with some suggesting it loses effectiveness over time and others arguing it maintains hair compared to baseline.

community Breezula by Cassiopea has had a successful Phase II. Apparenlty Phase III trials to start at the end of year. When are we potentially going to be able to get our hands on it?

alibabasfortythieves in Question 13 upvotes 5 years ago

The conversation discusses the hair loss treatment Breezula by Cassiopea, which had a successful Phase II trial and is expected to start Phase III by the end of the year. Users are curious about the timeline for availability and note that it performs slightly better than finasteride at 6 months, slightly worse at 12 months, with the benefit of having no side effects.

community Kintor develop GT20026 Anti-Androgen receptor drug with NO SIDES

itsnearlygone in Treatment 17 upvotes 4 years ago

The conversation discusses GT20029, a new topical drug for hair loss and acne without notable side effects, which has been accepted for investigational use in China. Some users express skepticism about the legitimacy of the company and the potential for other drugs like RU58841 to be developed due to patent expiration and lack of profitability.

community PP405 Drug in Action: Picture From Official Company Website

noeyys in Technology 775 upvotes 1 month ago

PP405 shows promise for hair follicle reactivation with minimal side effects. Users recommend continuing Minoxidil and Finasteride until more results are confirmed.

community New systematic review on topical and systemic spironolactone (2023)

aissuo in Research/Science 7 upvotes 1 year ago

Hair loss treatments discussed include Minoxidil, Finasteride, and RU58841. Topical and oral spironolactone show potential in improving hair growth when combined with topical Minoxidil.

community Earliest we can get legitimate pyrilutamide

StinkyMess in Research/Science 49 upvotes 2 years ago

Pyrilutamide, a drug in phase 3 trials in China, potentially becoming available in late 2023 or early 2024; Finasteride being used as a current treatment for hair loss; and the possibility of joining a group buy for black market versions of Pyrilutamide.

community cosmeRNA finally now it's pyrilutamide turn

Responsible_Pen_5465 in Chat 49 upvotes 1 year ago

Hair loss treatments discussed include cosmeRNA, minoxidil, finasteride, RU58841, and pyrilutamide. Users debate effectiveness, side effects, and upcoming treatments, with some expressing skepticism and others optimism.