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Glossary Dithiothreitol

chemical reducing agent that breaks disulfide bonds in proteins

Dithiothreitol (DTT) is a chemical compound used in biochemistry and molecular biology to break disulfide bonds in proteins, which helps to denature them and maintain their reduced state. This is particularly useful in experiments where maintaining the protein's structure is crucial, such as in electrophoresis or protein folding studies.

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community Other sulfurtransferase activity upregulator other than Tretinoin?

9 upvotes 3 years ago

The user does not respond well to minoxidil and is seeking an alternative to Tretinoin to upregulate sulfurtransferase activity for hair loss treatment. No specific alternative treatments were mentioned.

community I want to prepare a Topical Catalase with Phosphate Buffered Saline Solution.

2 upvotes 5 months ago

The conversation discusses creating a topical catalase solution with phosphate buffered saline, glycerin, and polysorbate 20 for hair loss treatment. The user seeks advice on preparing this solution.

community Diy dutesteride please help MCT oil or PG?

1 upvotes 9 months ago

A user is making their own dutasteride solution using MCT oil but is concerned about its effectiveness and bioavailability. They are considering using propylene glycol or adding ethanol for better results, while others suggest the current dosage might be excessive.

community Tretinoin buffering before minoxidil

7 upvotes 2 months ago

Buffering tretinoin with a moisturizer before applying minoxidil may help with itchy dandruff. Exfoliating the scalp with fingertips and using olive oil or conditioner can remove product buildup.

community Just received my 2 Deoxy D Ribose wish me luck🫡

245 upvotes 2 years ago

A user is trying 2-deoxy-D-ribose with distilled water for hair growth, observing new hair and skin pigmentation changes. Others compare it to Minoxidil, expressing interest and caution about its effectiveness and safety.

community For everyone buying 2-deoxy-d-ribose (2ddr)

12 upvotes 1 year ago

The conversation discusses using 2-deoxy-d-ribose (2DDR) for hair regrowth, with users sharing mixed experiences and side effects like hair loss in new areas and increased anxiety. The original poster plans to continue testing and comparing it to minoxidil, noting potential instability in 2DDR formulations.

community Is 2-deoxy-D-ribose (2dDR) good for human hair?

8 upvotes 2 years ago

Topical 2-deoxy-D-ribose (2dDR) regrows hair in mice almost as well as 2% Minoxidil. However, 2dDR may contribute to oxidative stress and hair loss due to the formation of advanced glycation end products (AGEs).

community Is it possible to make a propylene glycol free Minoxidil + Tretenoin solution?

in Minoxidil 2 upvotes 10 months ago

Creating a propylene glycol-free Minoxidil and Tretinoin solution to reduce skin irritation and enhance effectiveness. An emulsifier like lecithin can help mix Tretinoin properly, and Minoxidil foam is an alternative without propylene glycol.

community Peptide Therapy -> GHK-CU, ZN-Thumulin, PTD-DBM

4 upvotes 2 years ago

The conversation is about the use of peptide therapies for hair loss, specifically GHK-CU, ZN-Thymulin, and PTD-DBM. The user is seeking feedback on the effectiveness of these treatments from those who have tried them.

community mallia therapeutics 8T3 scd83 molecule for ffa/lpp mainly and aga

in Technology 9 upvotes 7 months ago

A user applied the 8T3 product for hair loss, targeting LPP and AGA, and plans to update on its effectiveness. The product uses a saline buffered phosphate vehicle, suitable for those intolerant to ethanolic vehicles.

community Naturally high T (1,100+) causing diffuse thinning while on Dut

22 upvotes 5 months ago

A 26-year-old male with high testosterone is experiencing diffuse hair thinning despite using a comprehensive treatment regimen including dutasteride, oral minoxidil, RU58841, ketoconazole shampoo, microneedling, and low-level laser therapy. Suggestions include adjusting dutasteride dosage, monitoring iron levels, and consulting a dermatologist for further evaluation.

community Looking to make my own 2-Deoxy-D-ribose. Any science bros can give advice?

7 upvotes 2 years ago

A user is making a 2-Deoxy-D-ribose solution and asks if it can be put into an oil instead of a gel, considering adding hydrocortisone and retinoic acid. They seek advice on the best carrier oil for hair growth.

community 2-Deoxy-D-Ribose official Product

5 upvotes 1 year ago

2-Deoxy-D-Ribose is discussed as a potential hair loss treatment, but skepticism exists due to lack of human testing. The original poster uses a combination of topical Minoxidil, oral Finasteride, topical RU58841, and other treatments, reporting some hair regrowth but not significant results.

community My personal thoughts on DHT. belive it or not

1 year ago

The conversation discusses a personal theory on the role of DHT in stress and reproduction, suggesting it converts testosterone for reproductive traits. The discussion includes skepticism and mentions individual differences in physiology and neurochemistry.

community DUT 3 times a week is the holy grail sweet spot, better than FIN every day.

6 upvotes 4 years ago

User "logart89" claims DUT 3 times a week is better than daily FIN for hair loss. Their routine includes DUT, topical DUT, stemoxydine and alfatradiol mix, 5% minoxidil with tretinoin, and weekly derma stamping.

community I reduced my serum DHT by 60% without Fin/Dut but not seeing any real stabilization or growth

in Update 2 upvotes 1 year ago

The user reduced serum DHT by 60% using Advanced Trichology's natural DHT blocker but saw no improvement in hair loss. They are considering switching to finasteride due to its proven effectiveness in inhibiting scalp DHT.

community What else can make hair more sensitive to DHT?

17 upvotes 1 month ago

Genetics, inflammation, poor scalp circulation, stress, thyroid issues, low iron, vitamin D deficiency, steroids, age, fungal infections, stress, and creatine can increase hair sensitivity to DHT. Treatments mentioned include dutasteride, minoxidil, and Kre Alkalyn Monohydrate.

community Anyone have an alternative solvent for pyrilutamide??

in Product 2 upvotes 2 years ago

The user is seeking an alternative solvent for pyrilutamide due to skin irritation from ethanol and propylene glycol. They experienced similar issues with topical minoxidil.

community Theory: 2 Deoxy D Ribose is a killer combi with microneedling

in Treatment 11 upvotes 2 years ago

2 Deoxy D Ribose may promote hair growth and aid wound healing, potentially enhancing microneedling effects. Users discuss its combination with microneedling for better hair growth results.

community two months on 2-deoxy-d-ribose (2ddr)

9 upvotes 1 year ago

The conversation discusses hair regrowth using 2-deoxy-d-ribose (2DDR) combined with minoxidil, with some users noting new hair growth. The original poster has been using minoxidil for 12 years and is considering combining 2DDR with finasteride, despite past side effects.

community i'm Considering adding hair stimulant: stemoxydine or alphatradiol

5 upvotes 1 year ago

The user is considering adding Stemoxydine to their hair loss regimen, as they already use topical finasteride with rosemary and cannot use Minoxidil. They are seeking feedback on Stemoxydine and Alphatradiol, and another user mentions 2-deoxy-d-ribose as a potential option.

community Vitamin E, tocotrienols discussion

4 upvotes 7 years ago

Tocotrienols are being discussed as a potential treatment for hair regrowth, but users report no noticeable effects after several months of use. Some users are combining tocotrienols with other treatments like pumpkin seed oil and peppermint and rosemary oil.

community Irritated scalp from tretinoin and alochol; any fixes?

in Treatment 2 upvotes 2 years ago

The user is experiencing scalp irritation from using tretinoin and alcohol-based hair loss treatments like stemoxydine. They find that Aquaphor helps with the pain but is difficult to apply in hairy areas.

community Today, The DHT Attacked

41 upvotes 8 years ago

The conversation humorously discusses the effects of DHT on hair loss, with references to treatments like finasteride and RU58841. Users share exaggerated stories about DHT's impact, highlighting its negative reputation.

community Increasing activity of the sult1a1 enzyme via alkalizing agent and tretinoin for better response to topical minoxidil

in Research/Science 4 upvotes 2 years ago

Increasing the sult1a1 enzyme on the scalp may improve response to topical minoxidil. The user suggests using a baking soda solution, DMSO, and tretinoin to enhance enzyme activity and minoxidil effectiveness.

community DHT is making fun of you, let's not suffer!

17 upvotes 11 months ago

DHT negatively affects scalp hair while promoting body hair growth, causing frustration due to the lack of permanent solutions for baldness. Users discuss treatments like finasteride and potential future solutions like CRISPR technology.

community Potential role of TB-500 Thymosin Beta-4

7 upvotes 1 year ago

The conversation discusses hair loss treatments, specifically mentioning Minoxidil, finasteride, RU58841, and TB-500 Thymosin Beta-4. It critiques the credibility of biohacking claims.

community Adding dut with fin to stop dht itch

2 upvotes 2 years ago

A user is seeking advice on adding dutasteride to their finasteride regimen to stop DHT-related scalp itch. They have tried selenium sulfide and ketoconazole shampoos with temporary success.

community Any experiences with Ptd-dbm??

8 upvotes 3 months ago

The user experienced reduced hair loss using an online serum but found it too expensive and is seeking a vendor for ptd-dbm. They are also interested in KY19382 but are unable to find it.

community which vitamin D test should one take before starting hair treatment ?

6 years ago

Vitamin D tests like D2, D3, and 25-hydroxyvitamin D are discussed before starting hair treatment. Vitamin D can be obtained from food, but overdose has side effects.