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GlossaryDissolving Microneedles

tiny, biodegradable needles that deliver drugs painlessly through skin

Dissolving microneedles are tiny, needle-like structures made from biodegradable materials that can painlessly penetrate the skin to deliver drugs or other therapeutic agents. Once inserted, these microneedles dissolve and release their payload directly into the targeted area, offering a minimally invasive alternative to traditional injections.

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community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 1 year ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

community after cosmerna is out will there be another hair loss drug released in 2023?

in Treatment 11 upvotes 1 year ago

User asks if Kintor, HMI-115, or Olix will release hair loss drugs in 2023. Conversation discusses potential treatments and release dates.

community Minoxidil and microneedling only - one year progress (m40+)

in Progress Pictures 1342 upvotes 4 months ago

A 40+ male shared his one-year progress using minoxidil twice daily and microneedling once a week, showing significant hair improvement. He also occasionally uses finasteride in a low dosage due to side effects.

community Keep Your Expectations Low when Using Fin

in Finasteride/Dutasteride 144 upvotes 5 months ago

Finasteride is not a miracle drug; results vary widely, with only 2/5 getting good results. Combining treatments like minoxidil and finasteride may help, but expectations should remain low.

community Sublingual Minoxidil - Cure to Hairloss?

in Minoxidil 583 upvotes 1 year ago

The conversation discusses the potential benefits of sublingual minoxidil for hair loss treatment. It suggests that sublingual minoxidil, which bypasses the liver, may have fewer side effects, greater bioavailability, and could be more effective than oral minoxidil.

community Should I give minoxidil a try or should I wait to see if I can get any more results from my regimen (fin, Ru58841, microneedling) almost at the 1year mark since starting also wondering if I can mix my ru58841 powder into minoxidil and just use that as my solvent

in Minoxidil 53 upvotes 1 year ago

The conversation discusses whether to add minoxidil to an existing hair loss treatment regimen that includes finasteride, RU58841, and microneedling. Some users suggest trying minoxidil and monitoring for side effects, while others advise waiting to see if current treatments improve results after one year.

community Can Finasteride be Enough to thicken hair?

in Finasteride/Dutasteride 22 upvotes 3 years ago

The user is using topical finasteride and is considering adding minoxidil despite concerns about dependency and side effects. Another user suggests that finasteride alone can reverse hair loss, but adding minoxidil and microneedling may improve results.

community STOP LYING FOR LORD'S SAKE because you're misleading people who are trying their best

in Chat 185 upvotes 2 months ago

Some users believe people falsely claim hair restoration results from finasteride and minoxidil alone, while actually having hair transplants. Finasteride and minoxidil, often used with microneedling and nizoral, are effective for many, but results and opinions on dosages vary.

community Didn’t realize how much volume was added until recently (1.5 yr on fin, 6 months on min)

in Progress Pictures 69 upvotes 1 year ago

The conversation discusses hair loss treatment progress, with the user being on finasteride for 1.5 years and minoxidil for 6 months. They mention experiencing occasional erectile dysfunction as a side effect.

community Amount of hairfall every day after 2 years on fin 1.5 years RU and 10 months oral min…

in Update 21 upvotes 1 year ago

The user is experiencing significant hair shedding despite 2 years on finasteride, 1.5 years on RU58841, and 10 months on oral minoxidil, and is frustrated with the ongoing issue. Another user shares a similar experience of losing a lot of hair daily for the last 3 years.

community Currently crushing 3 (5mg) tablets of fin into my topical min. Anyone do the same? If so how much do you add.

in Treatment 186 upvotes 7 months ago

The conversation discusses using crushed finasteride tablets mixed with topical minoxidil for hair loss treatment. Users share their experiences and opinions on the effectiveness and proper concentration of this method.

community The Big Fat Layer II

in Research/Science 26 upvotes 3 years ago

Hair loss treatment should target dermal white adipose tissue (DWAT) to restore hair follicles. Potential remedies include tocopherol (vitamin E), botox, rosiglitazone, niacin, kojyl cinnamate esters, and ADP355.

community 8 months min fin derma roller, how it’s look like?

in Is this regrowth? 706 upvotes 9 months ago

The conversation is about a user's hair regrowth after 8 months of using minoxidil, finasteride, and a derma roller. The user started seeing results after beginning derma rolling, using 0.25% finasteride and 5% minoxidil twice daily.

community Diffuse thinning is the worst possible balding experience

in Chat 80 upvotes 11 months ago

The conversation discusses the struggle with diffuse hair thinning and the effectiveness of treatments like finasteride, minoxidil, and RU58841. Users share experiences of hair thickening and shedding stopping with these treatments, but results vary and some are skeptical.

community Received a hair transplant today at 22 years old

in Transplants 108 upvotes 5 years ago

A 22-year-old's experience with receiving a hair transplant and the use of Minoxidil, finasteride, RU58841, Lidocaine shots, and platelet injections to treat hair loss.

community 14 Months on nuclear stack (0,5 DUT and 15mg oral Minox and no regrowth. Aga is impossible to beat

in Progress Pictures 1 year ago

The user has been on a hair loss treatment for 14 months using dutasteride and oral minoxidil without seeing regrowth and is considering adding more drugs due to the psychological impact of hair loss. However, replies suggest the user may not actually be experiencing noticeable hair loss.

community 4.5 month hair transformation with HOMEMADE topical solution. Saying bye to the Norwood reaper.

in Progress Pictures 128 upvotes 6 months ago

A user shared their 4.5-month hair transformation using a homemade topical solution with 5% minoxidil and crushed finasteride pills, applied twice daily with weekly microneedling. They plan to switch to once-daily application with tretinoin gel to enhance absorption.

community What is worth dissolving in topical minoxidil solution?

in Treatment 3 upvotes 3 months ago

Switching from minoxidil foam to topical solution and considering adding caffeine, melatonin, or cetirizine. Currently using 2.5mg oral minoxidil and 1mg oral finasteride, planning to ask for 0.5mg oral dutasteride and 5mg oral minoxidil.

community topical finasteride: dissolving finasteride in "alpacin cafeine liquid"?

in Finasteride/Dutasteride 1 upvotes 1 year ago

A user discusses using Alpecin Caffeine Liquid for scalp health and considers dissolving finasteride tablets into it for a DIY topical treatment. They inquire about potential absorption issues with this method.

community What can I use to prepare a lotion that doesn't irritate my scalp or make my hair sticky? (Want to experiment with metformin and Alpha Keto glutarate)

in Product 2 upvotes 1 year ago

The conversation is about a user who tried dissolving a metformin pill in water for hair treatment but faced issues with hair sticking together. The user is seeking advice on preparing a non-irritating, non-sticky lotion at home, possibly experimenting with metformin and Alpha Keto glutarate.

community What’s the highest minox % you home brewed ?

in Minoxidil 2 upvotes 5 months ago

A user discusses their experience with dissolving high concentrations of minoxidil in various ethanol/PG ratios and mentions difficulties with combining it with RU58841. They note that a 5% minoxidil solution remains stable, while higher concentrations tend to precipitate.

community Topical fin formulation question

in Finasteride 91 upvotes 1 week ago

A user is making a homemade topical finasteride solution by dissolving crushed finasteride tablets in ethanol and PG. They are unsure if the final solution maintains the intended concentration after filtering and are considering adding more ethanol to ensure accuracy.

community How are you using topical melatonin?

in Treatment 1 upvotes 8 months ago

The user is experimenting with topical melatonin for hair loss by dissolving melatonin tablets in a solution, but is having trouble with dissolution and is curious about others' methods of application and any effects on energy levels. They mention considering mixing with minoxidil but have not done so, and suggest that melatonin is best used at night.

community How to make topical finasteride?

in Finasteride/Dutasteride 1 upvotes 1 year ago

The conversation is about making a topical finasteride solution by dissolving crushed finasteride tablets in an alcohol-based hair treatment. Ingredients of the hair treatment include alcohol, water, and various plant extracts and preservatives.

community I just ordered 5 grams of melatonin to make a topical solution

in Research/Science 6 upvotes 2 years ago

The conversation discusses creating a topical hair loss treatment by dissolving melatonin in ethanol and possibly mixing it with castor oil, questioning the stability of the solution. An alternative of using glycerin is also considered.

community How to mix Viagra for topical application?

in Treatment 6 upvotes 1 year ago

The conversation is about experimenting with topical Viagra or Cialis for hair loss, including methods for dissolving the tablets. The user is also using herbal oil massages and considering using Ethanol/Propylene Glycol for better dissolution.

community Taking small Finasteride doses

in Finasteride/Dutasteride 1 upvotes 1 year ago

The user has been taking small doses of Finasteride, mixed with Stemoxydine, which has helped maintain their existing hair but not regrow new hair. They're considering dissolving the Finasteride in high-alcohol content drinks for easier administration and are seeking opinions on this method.

community How to apply topical Fin with this cone? Feel like everything is stuck on my hair and does not reach my scalp. Feels less effective than oral fin.

in Finasteride/Dutasteride 10 upvotes 1 week ago

The conversation discusses switching from oral to topical finasteride for hair loss, with concerns about application methods and side effects like dizziness and low energy. Users suggest mixing finasteride with minoxidil for better scalp coverage and dosage control.

community Minoxidil BAILLEUL 5% Men - Systematic Crystallisation In Sprayers and Bottles

in Minoxidil 2 upvotes 10 months ago

The post discusses issues with Minoxidil BAILLEUL 5% Men, specifically sprayer clogging and crystallization in bottles. Recommendations include rinsing the sprayer and soaking the bottle in hot water to dissolve crystals, with calculations suggesting the product remains effective despite these issues.

community Can I used Minoxidil 5 times a week and have it be effective? (Details in post)

in Minoxidil 7 upvotes 1 year ago

A user is using a compounded hair loss treatment with 5% minoxidil, 0.005% finasteride, and 0.01% tretinoin but is experiencing issues with residue and greasiness. They are inquiring if using the treatment five times a week instead of daily will still be effective.