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    GlossarySkin Fibrosis (Dermal Fibrosis)

    excessive fibrous tissue buildup in skin causing thickening

    Skin fibrosis, also known as dermal fibrosis, is a condition characterized by the excessive accumulation of fibrous connective tissue in the skin. This can result from chronic inflammation, injury, or diseases such as scleroderma. The overproduction of collagen leads to thickening, hardening, and scarring of the skin, which can impair its normal function and elasticity.

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      community I think I’ve finally found the reason for my hair loss

      in Chat  98 upvotes 2 weeks ago
      The user experienced hair loss since 2019 and tried finasteride, dutasteride, RU58841, and ketoconazole shampoo without success. A scalp biopsy showed scarring and inflammation from folliculitis, indicating chronic inflammation was affecting treatment effectiveness.

      community The Big Fat Layer II

      in Research/Science  26 upvotes 3 years ago
      Hair loss treatment should target dermal white adipose tissue (DWAT) to restore hair follicles. Potential remedies include tocopherol (vitamin E), botox, rosiglitazone, niacin, kojyl cinnamate esters, and ADP355.

      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  742 upvotes 2 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

      community The Big Fat Layer / Remedies: Cetirizine

      in Treatment  12 upvotes 3 years ago
      Treating hair loss with various remedies, such as Cetirizine and the Big3 complex (minoxidil, finasteride, and RU58841), which have properties like adipogenic, anti-fibrotic and anti-inflammatory. References to research studies are also included.

      community Hair theory Scar tissue and Verteporfin

      in Chat  26 upvotes 6 months ago
      A user suggests that deeper microneedling with Verteporfin injections might help regrow hair in areas with scar tissue, alongside a DHT blocker. Another user explains that hair loss might be due to reduced Wnt/β-Catenin signaling and suggests that treatments like Minoxidil, Finasteride, and microneedling could potentially reverse it.

      community Losing gains from 7 months of oral min, fin, dut.

      in Update  66 upvotes 1 year ago
      A user reported losing hair after 7 months of using oral minoxidil, finasteride, and dutasteride, but others reassured that this is likely just a shedding phase where old hairs fall out to make way for new growth. Some users experience sheds every 7-8 months and suggest staying consistent with treatment.

      community The MPB itch aka DHT itch is very real.

      in Chat  9 upvotes 1 year ago
      Hair loss itch is caused by DHT attacking follicles and stimulating nerves. Finasteride users who respond well don't experience this itch.

      community Comprehensive Microneedling Guide

      in Microneedling  293 upvotes 2 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Testosterone in Reference Range Doesn't Cause Hair Loss

      in Research/Science  51 upvotes 10 months ago
      Testosterone within the normal range does not significantly contribute to male pattern baldness (MPB); DHT is the main factor that can be controlled. Genetics play a crucial role in hair loss, and treatments like finasteride and dutasteride, which block DHT, can help despite potentially raising testosterone levels.

      community A Different Take on Curing MBP

       16 upvotes 5 years ago
      Addressing hair loss by focusing on posture, blood flow, and craniofacial development. Methods include improving posture, cardiovascular activity, scalp massages, healthy diet, meditation, using minoxidil, and addressing craniofacial issues.

      community Scalp Calcification - Inflamation

       6 upvotes 5 years ago
      A young male in his twenties discusses hair loss, mentioning the use of Minoxidil, topical finasteride, and occasional derma rolling. He inquires about scalp inflammation, fibrosis, and the potential benefits of magnesium oil and scalp massages for improving blood flow and hair health.

      community Opinions on Scalp fibrosis and DHT?

      in Research/Science  9 upvotes 2 years ago
      The conversation discusses the theory that scalp fibrosis contributes to male pattern baldness (MPB) by increasing DHT concentration, and mentions treatments like Minoxidil. The user seeks opinions on the theory and the effectiveness of scalp massages.

      community To anyone that is still not seeing results on the big 3…

      in Treatment  106 upvotes 2 years ago
      User redh0t12 suggests using a derma pen for hair regrowth, as it helped them after using finasteride and minoxidil. Others discuss their experiences with various treatments, including derma rolling, oral and topical minoxidil, and finasteride, with mixed results.

      community Finasteride and natural topicals

      in Finasteride  6 upvotes 6 years ago
      A user reported hairline regrowth after two weeks on a treatment including finasteride, peppermint and rosemary oils, emu oil, magnesium oil spray, apple cider vinegar, and dermarolling, while avoiding shampoos and conditioners. They believe DHT contributes to hair loss but also suggest follicle fibrosis is an issue.

      community I am actually regrowing my hairline without minoxidil or finasteride (mechanical stimulation)

       128 upvotes 6 years ago
      Regrowing hairline without the use of Minoxidil or Finasteride, and instead using mechanical stimulation such as Derma Roller, Nizoral, Zinc Pyrithione, Scalp Massage, Scalp Exercise, Fish Oil and other topical solutions. It is cautioned that there are risks associated with not using medically-prescribed treatments, but it is suggested to consider mechanical stimulation in addition to those prescribed treatments.

      community 1 Month Topical Minoxidil Only

      in Progress Pictures  72 upvotes 1 year ago
      The conclusion of the conversation is that the user plans to use topical minoxidil, ketoconazole shampoo, and a derma stamp for hair loss treatment. They also plan to start using finasteride in the next 2 months. Other users suggest using finasteride and a hair transplant for better results. The user appreciates the feedback and will continue posting progress.

      community Question about Castor oil and other oils?

      in Question  6 upvotes 6 years ago
      Castor oil's effectiveness for male pattern baldness, receding hairline, and thinning crown is questioned, including its application method and potential side effects. The user also mentions experiencing hair shedding with coconut oil.

      community Haircafe on why microneedling is bad for hair growth

      in Microneedling  156 upvotes 4 months ago
      Microneedling combined with minoxidil and finasteride shows significant hair regrowth, though opinions on its effectiveness vary. Some users report substantial benefits, while others highlight the need for more research and consistency in application.

      community My hair after 3 steroid cycles

      in Progress Pictures  27 upvotes 5 months ago
      A user shared their hair progress after three steroid cycles, using 5% minoxidil and 100mg RU58841 daily. They are considering a hair transplant due to paranoia about shedding.
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