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GlossaryLipolysis (fat degradation)

biological process breaking down fats into glycerol and fatty acids

Lipolysis is the biological process where fats (lipids) stored in fat cells (adipocytes) are broken down into glycerol and free fatty acids. This process is crucial for providing energy to the body, especially during periods of fasting or intense exercise, and is regulated by hormones such as adrenaline, noradrenaline, and insulin.

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community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 1 year ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

community HUGE: Pyrilutamide seems to be stable for at least 3 weeks into KB solution. So, that means stable with water content and not degradation according to Anageninc! They will keep testing the stability further. Check the video! Many thanks to the guy AlphaMode.

in Update 72 upvotes 1 year ago

The potential stability of pyrilutamide in a mixture with water, and how it could be used in combination with Minoxidil and Finasteride to treat hair loss.

community Found it. Sulforaphane, a phytochemical in broccoli sprouts, promotes hair growth (60% regeneration in mice) by accelerating the degradation of DHT.

112 upvotes 7 years ago

Sulforaphane, found in broccoli sprouts, promotes hair growth by degrading DHT. Users discuss its potential benefits and joke about unconventional application methods.

community 21M with a nasty case of MPB; Heres what's on my radar for the future.

in Research/Science 16 upvotes 2 years ago

Hopeful treatments for hair loss, including Verteporfin, Androgen Receptor Degradation, and SCUBE3. These treatments offer potential solutions to slow or stop the effects of androgens on the scalp.

community Stacking Fluridil / Topilutamide with other + aqueous topicals?

in Technology 1 upvotes 5 months ago

The conversation discusses how to use fluridil/topilutamide with other hair loss treatments like liquid minoxidil and CB-03-01, considering fluridil's hydrophobic nature and potential degradation with water. The user questions the necessity of washing hair only once per week as suggested by the manufacturer.

community Mixing Stemoxydine 5% with premixed solution of RU58841 5%

in Research/Science 2 upvotes 7 months ago

The user is using Dutasteride, Nizoral, and RU58841 for hair loss and is considering mixing RU58841 with Stemoxydine for better scalp coverage but is concerned about the potential degradation of RU58841 when mixed with a water-based solution. They are seeking advice on the feasibility of this mixture.

community Does RU58841 have to be refrigerated? Source?

in Treatment 1 upvotes 1 year ago

RU58841 should be refrigerated. The KB Solution is more effective at delivering RU58841 to the scalp.

community Pyrilutamide should not be mixed with Minoxidil?

in Product 7 upvotes 2 years ago

Pyrilutamide should not be mixed with Minoxidil because the water in Minoxidil can degrade it. It's suggested to apply Minoxidil first, wait an hour, then apply Pyrilutamide.

community Can I mix tretinoin cream into minoxidil?

in Minoxidil 6 upvotes 3 weeks ago

The conversation discusses using tretinoin cream with minoxidil for hair loss treatment. Users suggest applying them separately to avoid reducing effectiveness.

community how does my progress look 18M 3 months on fin 1mg daily

in Progress Pictures 277 upvotes 1 year ago

An 18-year-old male's successful hair regrowth after three months of using finasteride 1mg daily. He reported no side effects and other users expressed admiration and curiosity about his results.

community SCUBE3 and GT20029 could be the closet thing to a cure: Hair Follicle Regeneration and Protection Against DHT

in Research/Science 14 upvotes 1 year ago

SCUBE3 and GT20029 are potential treatments for hair loss, with SCUBE3 stimulating hair growth and GT20029 protecting against DHT. A combined approach using SCUBE3, finasteride or dutasteride, and later GT20029 could provide a comprehensive treatment for androgenetic alopecia.

community Is GT20029 a cure for further hairloss? Also what do you estimate its price to be?

in Research/Science 9 upvotes 1 year ago

The conversation discusses the potential of GT20029 to stop hair loss and possibly regrow hair, considering the body's regenerative abilities. No specific treatments were mentioned due to the original post being removed.

community Homemade Topical Finasteride Formula?

in Treatment 6 upvotes 2 years ago

User wants to make homemade topical finasteride to minimize side effects and asks about using glycerin, stirring time, storage, and alternative solvents. Another user's comment is unclear.

community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001) Pt 2

in Research/Science 480 upvotes 3 months ago

Sugary beverages increase the risk of pattern hair loss in men by 57%. Treatments discussed include Minoxidil, finasteride, and RU58841.

community Am I balding? Should I just shave it off?(M86)

in Satire 116 upvotes 5 months ago

A user humorously questions if they should shave their head due to hair loss, mentioning Ronald Reagan's impressive hair genetics. Replies include jokes and comments about jealousy and distrust towards older individuals with full heads of hair.

community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

in Research/Science 136 upvotes 7 months ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

community Breezula will hit the market in 2026, Cosmo Pharmaceuticals statement!

in Product 52 upvotes 8 months ago

Breezula, a hair loss treatment, is expected to cost around $100 a month and is anticipated to be released in 2026. The effectiveness of Breezula is debated, with some suggesting it loses effectiveness over time and others arguing it maintains hair compared to baseline.

community Shedding on finasteride only; looking for motivation

in Finasteride/Dutasteride 15 upvotes 8 months ago

A user started finasteride for hair loss and saw improvement, but is now experiencing shedding and thinning in new areas. They added Nizoral due to dandruff caused by finasteride. Replies suggest that shedding is normal around 6 months and advise to stick with the treatment.

community How to make a RU58841 solution (50mL 5% strength)

in Research/Science 33 upvotes 10 months ago

The conversation discusses making a RU58841 solution for hair loss prevention and includes personal experiences with using RU58841 and minoxidil for hair regrowth, with a mention of monitoring health effects.

community [10 months] Lookin Bout Halfway There👍👨‍🦲 — ru58841, dutasteride, minoxidil

in Progress Pictures 85 upvotes 1 year ago

The conclusion of the conversation is that the user "lemmeseesomeass" has experienced significant hair regrowth using a combination of RU58841, dutasteride, and minoxidil. They mention that RU58841 is effective but not medically approved. They provide instructions on how they use RU58841.

community Is GT20029 supposed to regrow hair as well?

in Treatment 10 upvotes 1 year ago

The user is considering switching from finasteride to dutasteride for hair loss. They are unsure if GT20029 can regrow hair, particularly on the temples. Another user mentions that regrowth on finasteride can take up to 2 years.

community Does melatonin dissolve in isopropyl alcohol

in Technology 6 upvotes 1 year ago

The conversation discusses making a topical melatonin solution for hair loss treatment, questioning if isopropyl alcohol can dissolve melatonin. Melatonin is soluble in lipids and alcohol, but it's unstable and should be mixed fresh regularly; it may help hair growth by affecting certain cellular signaling pathways and has anti-androgenic effects.

community New hack? Tretinoin enhances minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes

in Research/Science 16 upvotes 1 year ago

The conversation discusses how Tretinoin may improve the effectiveness of Minoxidil for treating hair loss by increasing the activity of certain enzymes in hair follicles. One user comments that this information is not new.

community 2.5 yrs progress: Min + dermaroll + niz

in Progress Pictures 76 upvotes 1 year ago

A user's 2.5 year hair loss progress with Minoxidil, dermarolling, and Nizoral treatments, as well as taking biotin and a multivitamin supplement, with the intention of trying DIY topical finasteride in the future.

community Pyrilutamide update, comparing with ru58841

in Research/Science 27 upvotes 1 year ago

Treatments for hair loss, including Minoxidil, finasteride, and RU58841. The post discusses the potential benefits of Pyrilutamide compared to RU58841 in terms of strength and longevity.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 674 upvotes 1 month ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Increased adipose tissue (being overweight) in males may increase likelyhood of finasterde side effects

in Research/Science 29 upvotes 2 months ago

Being overweight may increase finasteride side effects due to higher aromatase activity converting testosterone to estradiol. Maintaining a healthy weight could reduce these side effects.

community Consensus on pyrilutamide? i want to start but not sure…

in Research/Science 4 upvotes 3 months ago

The post and conversation discuss the effectiveness of pyrilutamide for hair loss, with comparisons to finasteride and RU58841. Users express skepticism due to failed trials and high costs, with some waiting for more data before trying pyrilutamide.

community Balding absolutely ruined my life at 17.

in Finasteride/Dutasteride 210 upvotes 3 months ago

A user is struggling with hair loss at 17 and has been using finasteride for 5 months and minoxidil for 11 months without seeing regrowth. Other users encourage continuing treatment, sharing their own experiences with finasteride, minoxidil, and dermarolling, and emphasizing patience and acceptance.

community To the late responders of finasteride. How long did it take to finally see results?

in Finasteride/Dutasteride 219 upvotes 5 months ago

Finasteride can take over a year to show results, with some users seeing significant improvements after 1.5 to 3.5 years. Patience is key, and combining treatments like minoxidil may help.