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GlossaryComplete Androgen Insensitivity Syndrome

genetic condition causing male individuals to develop female traits

Complete Androgen Insensitivity Syndrome (CAIS) is a genetic condition where an individual who is genetically male (with one X and one Y chromosome) is resistant to male hormones called androgens. As a result, the person has the physical traits of a female but does not have a uterus or ovaries, and typically has undescended testes. This condition is caused by mutations in the AR gene, which affects the body's ability to respond to androgens.

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community Fun thought experiment about halting hair loss permamently

in Research/Science 58 upvotes 5 months ago

A user proposed genetically engineering scalp stem cells to stop androgen receptors from causing hair loss. Others discussed the feasibility, existing research, and potential issues with this approach, including targeting the correct cells and unintended effects.

community Finasteride doesn't work for me in 2 years and my bloodtest result just came in.

in Progress Pictures 87 upvotes 10 months ago

A user has been treating hair loss with finasteride for two years without success and is experiencing an itchy scalp with seborrhea. Despite low DHT levels, they are still losing hair, suggesting that DHT might not be the main cause of their hair loss, and they are considering other treatments or causes.

community How does dutasteride regrowth work?

in Finasteride/Dutasteride 6 upvotes 4 months ago

A 25-year-old man with hair loss from bleach damage is using oral minoxidil and considering adding Dutasteride for better regrowth and prevention. He seeks advice on Dutasteride's effectiveness and potential benefits over finasteride, and is also curious about RU58841.

community Neck tension, and hair loss, I am 100 percent sure that there is a connection

in Treatment 19 upvotes 4 months ago

The user believes neck tension and poor posture contribute to hair loss, noticing improvements with yoga and muscle relaxation. Replies suggest androgenic alopecia as the cause and recommend exercises.

community Can anyone confidently say their erections are the same on fin ?

in Chat 240 upvotes 3 months ago

The conversation discusses the impact of finasteride on sexual function, with many users reporting reduced libido and weaker erections despite continuing the treatment to prevent hair loss. Some users suggest checking hormone levels or switching to different dosages or treatments like dutasteride, while others share mixed experiences regarding the severity of side effects.

community Pyrilutamide PHASE 2 Results just one months to go. Are you excited???🤩

in Research/Science 97 upvotes 2 years ago

Pyrilutamide, a potential topical treatment for male pattern baldness, and the user's anticipation of its Phase 2 trial results. Several users discussed their experiences with Finasteride and RU58841, while others voiced skepticism about the efficacy of Pyrilutamide.

community Is Pyrilutamide the real deal and if so when will it actually be available?

in Chat 21 upvotes 2 years ago

Pyrilutamide, a potential hair loss treatment that is currently in development and may be available soon; an androgen receptor degrader which is also being developed as a potential treatment for hair loss; and the comparison between Pyrilutamide, finasteride, minoxidil, and RU58841.

community 21 months on topical minoxidil and full HRT

in Transgender 214 upvotes 5 months ago

The conversation is about a transgender individual's experience with hair regrowth using topical minoxidil and hormone replacement therapy (HRT), expressing concern about the slow growth and thin appearance of their hair. Some responses encourage patience and highlight the variability of results, while others discuss the role of HRT and its effects.

community The safest way to use finasteride - my research

in Finasteride 23 upvotes 7 years ago

The post discusses microdosing finasteride to minimize side effects while treating hair loss. The user also mentions using minoxidil, biotin, and ketoconazole.

community A Complete Guide to Hair Loss for Beginners

in Research/Science 528 upvotes 9 months ago

The conversation is a guide on treating hair loss, discussing finasteride and dutasteride to lower DHT, minoxidil for growth, ketoconazole shampoo for scalp health, and dermarolling for regeneration. RU58841 is mentioned as a DHT blocker but not recommended due to safety concerns.

community One year anti androgen update CROWN

in Finasteride/Dutasteride 343 upvotes 1 year ago

User used Finasteride, Dutasteride, and Minoxidil for one year to treat hair loss. They discussed possibly trying RU58841 or pyrilutamide in the future.

community How is there no topical anti-androgen that doesn’t go systematic?!

in Treatment 7 upvotes 4 years ago

Hair loss treatments discussed include Minoxidil, Finasteride, RU58841, Alfatradiol, and Eucapil. Topical treatments must penetrate skin and may go systemic, with effectiveness varying.

community If RU58841 is such an effective anti androgen

in Research/Science 46 upvotes 9 months ago

RU58841 is discussed as a topical anti-androgen for hair loss, but its effectiveness and safety are not well-documented, leading to mixed opinions and experiences among users. Some combine it with finasteride, but concerns about side effects and lack of FDA approval limit its popularity.

community Best hair loss treatments ranked: a complete guide

361 upvotes 5 years ago

Hair loss treatments, including Dutasteride 0.5mg daily, finasteride 1mg daily, minoxidil 5% 2x daily, dermarolling, low-level light therapy (LLLT), ketokonazole shampoo, and diet optimization; discussing their effectiveness and side effects.

community [1.4 years] [Day 240 dutasteride][pics] hair loss gets worse, I am a complete non responder, DHT inhibition does not halt hair loss for me. Should I try minoxidil?

in Minoxidil 6 upvotes 8 years ago

The user experienced worsening hair loss despite using finasteride and dutasteride. They are considering trying minoxidil but are unsure if it will help.

community If gt20029 works, will it be a cure for completely bald people too?

in Chat 12 upvotes 2 months ago

The conversation discusses whether gt20029 could cure complete baldness, mentioning verteporfin as a realistic treatment. Other treatments like Minoxidil, finasteride, and RU58841 are implied to be less promising.

community New Approach to Ketoconazole or just waste of time?

in Ketoconazole 21 upvotes 4 months ago

The post discusses using 2% ketoconazole shampoo as a competitive androgen receptor antagonist for hair loss, applied for 1.5 hours daily. The user questions its effectiveness and potential benefits compared to finasteride and minoxidil.

community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

in Research/Science 134 upvotes 5 months ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 96 upvotes 4 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community Theoretically won't this be better than finasteride? Azelaic acid + zinc

in Research/Science 9 upvotes 1 year ago

The conversation discusses using zinc sulphate and azelaic acid to inhibit 5 alpha-reductase activity, which could potentially treat androgen-related skin conditions like hair loss. Combining these with vitamin B6 could enhance the effect, potentially offering an alternative to finasteride.

community Kintor’s GT20029 Phase 1 success

in Update 74 upvotes 1 year ago

Kintor's GT20029, a treatment for hair loss, has completed Phase 1 successfully, showing promise as an androgen receptor degrader that could potentially regrow hair. It is considered more effective than Pyrilutamide, with infrequent dosing and minimal systemic absorption.

community Does anyone have the removed Breezula phase II 12 month baseline comparison results?

in Research/Science 8 upvotes 3 years ago

The conversation discusses the removal of Breezula phase II 12-month results by Cassiopea and the search for the original data. Concerns were raised about potential negative long-term effects on hair growth, such as androgen receptor upregulation.

community The New, Improved CB-03-01/Setipiprant Group Buy

27 upvotes 8 years ago

The group buy for CB-03-01, a topical anti-androgen for hair loss, was postponed and refunded due to issues with the product's form and solubility. The product, also known as Breezula, is an alternative to finasteride with fewer side effects, but its official release is delayed until 2021.

community My Experience With Finasteride

in Research/Science 21 upvotes 1 year ago

A user shared their experience with Finasteride for hair loss, noting a significant reduction in DHT levels and a complete loss of libido without other side effects. Another user agreed, discussing the negative impact on sexual drive and criticizing the community's attitude towards discussing side effects.

community Kintor Pharma Announces Positive Top-line U.S. Phase I Trial Results of GT20029, the World’s First Topical Use PROTAC Compound

in Research/Science 127 upvotes 1 year ago

The conversation discusses positive initial trial results for GT20029, a topical compound for hair loss that degrades androgen receptors, potentially requiring only weekly application. Participants express hope for this treatment to be more effective and convenient than current options like Minoxidil, Finasteride, and RU58841.

community Kintor has announced the results for their human Phase I trials of GT20029

in Research/Science 256 upvotes 1 year ago

The conversation discusses the potential of a new hair loss treatment, GT20029, which may prevent hair loss by destroying androgen receptors on the scalp. Users express hope for the treatment's success and speculate on its usage routine, effectiveness, and possible side effects.

community Trestolone (MENT) as a nuclear treatment

in Treatment 99 upvotes 2 years ago

Experimenting with trestolone as a treatment for hair loss in an attempt to avoid DHT-related treatments such as finasteride and dutasteride, and discussing the potential effects of its receptor selectivity on the androgen receptors in the scalp.

community Binding affinity of pyrilutamide!

in Update 169 upvotes 2 years ago

Pyrilutamide, a nonsteroidal antiandrogen drug under development for the potential treatment of androgenic alopecia. The conversation discusses its binding affinity to the androgen receptor and the timeline for possible availability after trials are completed in the United States and China.

community 22 year old male, doctor prescribed 50mg oral spironolactone instead of finasteride.

6 upvotes 8 years ago

A 22-year-old male has been experiencing hair thinning since 18 and was prescribed 50mg oral spironolactone for hair loss and high blood pressure, despite inquiring about finasteride. A reply suggests that spironolactone is less effective than finasteride and minoxidil for hair loss and recommends seeking a second medical opinion.

community UPDATE last post was august 13th(3rd slide). I’ve been taking oral min and fin once every morning. Dermastamping every week 1.5 length and using keto shampoo 2x a week. Is this genuine regrowth?

in Is this regrowth? 16 upvotes 3 days ago

The user is experiencing hair regrowth using oral minoxidil, finasteride, dermastamping, and ketoconazole shampoo. Suggestions include adding pyrilutamide or considering dutasteride instead of finasteride.