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GlossaryClinical Examination

thorough evaluation by a healthcare professional to assess health

A Clinical Examination, also known as a Physical Examination, is a thorough evaluation performed by a healthcare professional to assess a patient's overall health and identify any medical conditions. This process typically involves observing, palpating, percussing, and auscultating various parts of the body, as well as taking vital signs like blood pressure, heart rate, and temperature.

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community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

in Research/Science 136 upvotes 7 months ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

community microneedle, any long term users damage?

in Microneedling 35 upvotes 5 months ago

Microneedling is effective for hair growth, especially when combined with finasteride and minoxidil, but concerns exist about potential long-term skin damage. Users report increased collagen and elastin deposition, but the long-term effects on the scalp remain uncertain.

community discouraged about pyrilutamide

in Research/Science 11 upvotes 2 years ago

Discouragement regarding Pyrilutamide, a drug in development for hair loss, and the potential side effects of Finasteride. People discussed anecdotal experiences with Pyrilutamide as well as suggestions to wait out Phase 3 trials before making any conclusions.

community Better then Minoxidil( at least for me and my family)

in Treatment 42 upvotes 9 months ago

Capronium Chloride and Trichoxidil are suggested as better alternatives to Minoxidil for hair growth without heart side effects. The Japanese Dermatological Association recommends topical Minoxidil over Capronium Chloride.

community [study analysis] Microdose of topical Finasteride for all the benefits and none of the sides?

in Research/Science 104 upvotes 4 years ago

Topical finasteride as a potential alternative to oral finasteride for reducing DHT levels on the scalp with fewer side effects, and other hair loss treatments such as minoxidil.

community Hope Medicine announces HMI-115 phase II clinical trial for androgenetic alopecia in China

in Research/Science 61 upvotes 1 year ago

Hope Medicine's announcement of the HMI-115 Phase II clinical trial for androgenetic alopecia in China; other related trials have been conducted or are ongoing in different countries, including Australia, US, and Europe. There is speculation that the product may be accepted across borders without additional testing.

community Reddit’s Amatorial microneedling meta analysis of 11 different Clinical studies for a Total of 559 patients (Scalp microneedling + topical minoxidil 5%, safety, efficacy and Ideal protocol)

in Microneedling 329 upvotes 2 years ago

Microneedling with 5% minoxidil improves hair growth for hair loss patients. Best protocol: 1.5mm dermaroller weekly for 12 weeks or 0.6mm dermapen every 2 weeks for 12 weeks, skipping topicals for 24 hours.

community HMI 115 Phase 1 update: Changes to clinicaltrials.gov page

in Research/Science 25 upvotes 1 year ago

A Phase 1 update for the HMI 115 clinical trial, which involves 16 participants and is expected to end in July 2023; as well as changes to the recruitment process, including treatment protocols with Minoxidil, Finasteride, and RU58841.

community 3 months in and I think there’s a slight difference. Microneedling 1xweek and minox twice a day

in Progress Pictures 191 upvotes 2 years ago

Using Microneedling 1xweek and Minoxidil twice a day as treatments for hair loss, along with DHT blockers such as Finasteride or Dutasteride. Advice was also given to not raise eyebrows when evaluating hair growth progress.

community how it feels to talk to tiktok kids about hairloss that isn’t shitty rosemary oil bloodflow and microneedling

in Satire 992 upvotes 1 month ago

Minoxidil and finasteride are effective for hair loss, especially when used together. Microneedling may enhance minoxidil's effects, but its standalone effectiveness is uncertain.

community Kintor's email response to me, regarding false advertising, and my proposal for them to develop a topical dut formulation with meaningful efficacy.

in Treatment 46 upvotes 3 months ago

Kintor apologized for using misleading images in their advertisements and promised stricter review processes. They are also considering developing a topical dutasteride formulation.

community Follicum releases some data from previous phase 2a trial

in Research/Science 13 upvotes 1 year ago

Follicum discovered that their drug FOL-005 increased hair count by 12 hairs per cm2 in patients with less than 255 hairs per cm2 and is planning a phase 2b trial. They are currently fundraising for the trial, and the drug may also be effective for women.

community Binding affinity of pyrilutamide!

in Update 168 upvotes 2 years ago

Pyrilutamide, a nonsteroidal antiandrogen drug under development for the potential treatment of androgenic alopecia. The conversation discusses its binding affinity to the androgen receptor and the timeline for possible availability after trials are completed in the United States and China.

community First patient dosed with Pyrilutamide (Kintor) Phase III

in Research/Science 201 upvotes 2 years ago

First patient dosed with Pyrilutamide (Kintor) Phase III for hair loss treatment. Pyrilutamide differs from approved treatments as it competes with DHT to bind hair follicles, potentially reducing side effects.

community Most Recent Interesting Hairloss Studies: 10% Minox vs 5% Minox / Radio Rrequency Treatment for AA / Topical Ketoconazole / PRP+Minox vs Minox vs PRP / Alopecia as a systemic disease

in Treatment 90 upvotes 4 years ago

Treatments for hair loss, such as topical minoxidil, platelet-rich plasma therapy with or without minoxidil, ketoconazole, non-abative radio frequency, natural products, finasteride and cortexolone 17 alpha propionate. The post evaluates the efficacy and safety of these treatments in various studies.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community I am finally giving up on my hair

in Shaved/buzzed 57 upvotes 1 year ago

User tried Minoxidil and Finasteride for hair loss with no success and considers giving up. Others suggest continuing treatment, trying hair transplant, or embracing baldness.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 44 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community KX-826 Pyrilutamide1% coming soon

in Update 152 upvotes 3 months ago

KX-826 Pyrilutamide 1% is launching soon, and users are discussing its potential benefits and drawbacks compared to other treatments like Minoxidil and finasteride. Some users are skeptical about its effectiveness, while others are hopeful it will be a safer alternative.

community Whoever had success with PYRILUTAMIDE, please give us hope outside of 5AR inhibitors.

in Product 7 upvotes 3 months ago

Users discuss using pyrilutamide for hair loss, seeking alternatives to 5AR inhibitors. They mention using minoxidil, ketoconazole shampoo, and RU58841.

community Let's be clear, does Finasteride stop MPB as long as it's taken?

in Finasteride/Dutasteride 170 upvotes 7 months ago

Finasteride is believed to slow down hair loss significantly, but may not completely stop it for everyone. Effectiveness and duration vary by individual, with some users experiencing positive results for over 10 years, while others see less benefit.

community Another clueless guy fearmongering and spreading misinformation

in Chat 251 upvotes 9 months ago

The conversation discusses hair loss treatments, with some users advocating for finasteride and minoxidil, while others express concerns about potential side effects of finasteride. A social media influencer is criticized for promoting scalp massages and minoxidil over finasteride, which some believe is misinformation.

community My experience and a discourse on “DUPA”

in Chat 46 upvotes 1 year ago

How diffuse unpatterned alopecia (DUPA) is not an invitation to self-diagnose oneself with aggressive AGA and that seeking a specialized dermatologist may help people experiencing hair loss. Treatment options discussed include topical clobetasol propionate, oral minoxidil, and discontinuing finasteride.

community Ru58841 ruined my life. Here’s why.

in Product 127 upvotes 2 years ago

User experienced shortness of breath, high blood pressure, red eyes, and eye floaters after using RU58841 for hair loss. They warn others to avoid RU58841 and stick to finasteride, minoxidil, and dutasteride.

community Dermarolling is a bit sad innit?

in Microneedling 232 upvotes 3 years ago

Hair loss treatments discussed include dermarolling, minoxidil, finasteride, and RU58841. Some users find dermarolling sad, while others mention the complexity of biological systems and limited research funding for hair loss.

community find a cure for this shit already

in Chat 207 upvotes 4 years ago

Treatments used to prevent and treat male pattern baldness, the difficulty in finding a permanent cure for hair loss, and the potential financial motivations of companies not wanting to find a cure.

community Redensyl (The Ordinary Serum)

in Treatment 20 upvotes 4 years ago

Redensyl, a hair loss treatment that has been claimed to be 80% more effective than minoxidil, but users have not experienced any results from using it.

community If you’re sitting there wondering, “I’m losing my hair, what do I do?” then read my advice here. I’ve been fighting the fight for 7 years, with great success. (pictures included)

in Question 106 upvotes 11 years ago

Fighting hair loss with "The Big 3" treatments of Propecia, Rogaine and Nizoral shampoo, as well as specific advice on how to use these products. People have shared their long-term success stories and some have discussed the side effects of finasteride. Other suggestions included Lipogaine and Pura D'or Hair Loss Prevention Therapy Shampoo & Conditioner.

community Target Area Hair Count (TAHC) increase comparasion of all future treatments in clinical trial phases

in Research/Science 38 upvotes 7 months ago

Finasteride, Minoxidil, Bioneer CosmeRNA, Technoderma, Kintor, Hope, Breezula, and Follicum treatments showed increases in hair count, with Technoderma showing the highest increase at 24.3 hairs/cm². Amplifica has not yet published results.

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

in Research/Science 101 upvotes 2 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.