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GlossaryChemical Enhancers

substances increase skin or hair follicle permeability for better treatment delivery

Chemical enhancers are substances used to increase the permeability of the skin or hair follicles, allowing for more effective delivery of medications or treatments. In the context of hair and alopecia, these enhancers can help topical treatments penetrate deeper into the scalp, improving their efficacy in promoting hair growth or reducing hair loss.

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community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 76 upvotes 6 months ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community The theory that explains everything. Please help me make this big!

in Research/Science 2448 upvotes 3 years ago

The post and conversation are about the role of the enzyme 3alpha-hydroxysteroid reductase in hair loss and the potential of compounds like procyanidin B2 and sulforaphane to boost its activity for hair regrowth. Further research is needed to develop effective treatments based on this theory.

community New hack? Tretinoin enhances minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes

in Research/Science 15 upvotes 2 years ago

The conversation discusses how Tretinoin may improve the effectiveness of Minoxidil for treating hair loss by increasing the activity of certain enzymes in hair follicles. One user comments that this information is not new.

community Using essential oils as well as minoxidil?

in Minoxidil 6 upvotes 6 years ago

The conversation is about using a blend of coconut oil, peppermint oil, and rosemary oil with minoxidil for hair loss, and whether it's safe to apply this blend after microneedling.

community Pyrilutamide ,the molecule’s true nature

in Research 302 upvotes 4 months ago

Pyrilutamide is a selective AR antagonist with a high binding affinity, making it effective in competing with DHT for androgen receptors. The 1% concentration is more effective than the 0.5%, but the latter may suffice for mild hair loss; the drug is considered a good option for those avoiding 5AR blockers due to side effects.

community Sugars ARE important for hair growth | Glycosaminoglycans as Hair Growth Stimulant

in Research/Science 80 upvotes 5 months ago

Glycosaminoglycans are important for hair growth, and combining minoxidil with tretinoin and Biopeptide-CL may enhance hair growth by boosting glycosaminoglycan levels and improving the hair follicle environment. Users discussed the potential effectiveness and future of these treatments.

community Hairloss Treatment - General health and efficacy-conscious stack overview

in Treatment 3 months ago

The conversation discusses managing hair loss and seborrheic dermatitis with treatments like minoxidil, finasteride, and saw palmetto, emphasizing the importance of scalp health and DHT reduction. The user shares personal experiences and suggests a balanced approach, combining topical treatments and lifestyle changes for effective hair regrowth.

community Alright boys, who’s willing to burn their scalp for science?

in Research/Science 765 upvotes 1 year ago

Researching the effects of scalp trauma on hair growth, with some users suggesting experimenting with a soldering iron or derma pen, and others bringing up studies that suggest this may be an effective treatment.

community Progress o regress? 2 Years only dermaroller (and RU for only 2 month)

in Is this regrowth? 70 upvotes 2 years ago

The conversation discusses hair loss and treatments, with users suggesting the original poster's hair has receded despite using a dermaroller and RU58841 for two months. Many recommend starting finasteride and minoxidil for better results.

community Fue Hair Transplant Surgery after 2 Years Result – Hair of Istanbul Clinic

in Update 351 upvotes 2 years ago

A user sharing the results of their hair transplant surgery after two years, with some commenters noting that it looks unnatural and others praising the result. Several users suggest specific treatments such as Toppik, Minoxidil, Finasteride and RU58841 to improve the look.

community DIY treatment... Shedding completely stopped after 1.5 yrs

in Treatment 252 upvotes 2 years ago

Vitamin C mixed with shampoo stopped shedding and promoted hair regrowth after 1.5 years. Both the person and their wife experienced significant hair loss reduction with this method.

community Castor oil without using penetration enhancer after microneedling?

in Question 9 upvotes 6 years ago

The conversation is about whether castor oil can be effectively used alone after microneedling without a penetration enhancer like DMSO or ethanol. The user believes microneedling-induced wounds might be enough for absorption.

community Melatonin a possible tool to help fight AGA hair loss.

in Research/Science 51 upvotes 3 years ago

Topical melatonin may help reduce hair loss and increase hair thickness in people with androgenetic alopecia (AGA), with some studies showing positive results. It can be mixed with minoxidil for application, and its effectiveness might be enhanced when used with micro-needling, but results may vary among individuals.

community Comprehensive Microneedling Guide

in Microneedling 289 upvotes 2 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

community Does anyone know what % of DHT does topical azelaic acid blocks?

in Research/Science 13 upvotes 2 years ago

The conversation is about the effectiveness of topical azelaic acid in blocking DHT for hair loss treatment. Specific treatments discussed include Minoxidil, finasteride, and RU58841.

community Impressed by the progress but think it’s time to go for the transplant?

in Progress Pictures 288 upvotes 11 months ago

The user started taking 2.5mg minoxidil tablets daily and reduced their finasteride dose to 0.5mg due to side effects. They are considering a hair transplant but are unsure if they should proceed now or wait after seeing the effects of the reduced finasteride dosage.

community Before & after for 3 months of minoxidil & 6 months of finasteride/minoxodil/tretinoin

in Progress Pictures 647 upvotes 3 weeks ago

A 36-year-old experienced significant hair regrowth using minoxidil, finasteride, and tretinoin with minimal side effects. He plans to continue the treatment, hoping for more targeted solutions in the future.

community One year anti androgen update CROWN

in Finasteride/Dutasteride 334 upvotes 1 year ago

User used Finasteride, Dutasteride, and Minoxidil for one year to treat hair loss. They discussed possibly trying RU58841 or pyrilutamide in the future.

community What regimen do I need to get this hairline?

in Satire 366 upvotes 1 year ago

Discussing a regimen to improve the user's hairline, with treatments proposed including minoxidil, rectal microneedling, IV drip of minoxidil, laser removal, PRP injection, topical minoxidil, divine protein shakes, stem cell injections, and keto shampoo.

community Please stop looking for a natural way to stop your hairloss

in Chat 369 upvotes 3 years ago

No natural way to stop hair loss, pharmaceuticals only option. Users discuss Minoxidil, Finasteride, natural remedies, and healthy scalp importance.

community Keratin microspheres - breakthrough

in Research/Science 13 upvotes 10 months ago

A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

community Why is Minoxidil not enough for hair loss? (No fin)

in Minoxidil 55 upvotes 1 month ago

Minoxidil alone is often insufficient for treating hair loss because it doesn't address the DHT-related cause. Combining it with finasteride, a DHT blocker, is generally more effective.

community Can anyone confidently say their erections are the same on fin ?

in Chat 240 upvotes 7 months ago

The conversation discusses the impact of finasteride on sexual function, with many users reporting reduced libido and weaker erections despite continuing the treatment to prevent hair loss. Some users suggest checking hormone levels or switching to different dosages or treatments like dutasteride, while others share mixed experiences regarding the severity of side effects.

community Rosemary out here changing lives for the better

in Treatment 90 upvotes 7 months ago

Rosemary oil is being used as an addition to minoxidil and finasteride for hair health, with mixed opinions on its effectiveness. Some users report positive results, while others see no benefit or experience adverse effects.

community Creatine's effect on Hair Loss and DHT

in Research/Science 100 upvotes 10 months ago

A 21-year-old male managed to control his hair loss using Nizoral, RU58841, and finasteride, but experienced increased scalp itchiness after starting creatine, which subsided upon stopping creatine. Users shared mixed experiences on whether creatine affects hair loss, with some reporting negative effects and others seeing no change or defending its benefits.

community Anyone else growing tired of the finasteride wars?

in Finasteride/Dutasteride 169 upvotes 1 year ago

The conversation is about differing experiences with finasteride for hair loss, with some users reporting side effects and others not, and the debate over the drug's safety and effectiveness. Specific treatments mentioned include finasteride, dutasteride, and topical finasteride.

community 1 Month Topical Minoxidil Only

in Progress Pictures 72 upvotes 1 year ago

The conclusion of the conversation is that the user plans to use topical minoxidil, ketoconazole shampoo, and a derma stamp for hair loss treatment. They also plan to start using finasteride in the next 2 months. Other users suggest using finasteride and a hair transplant for better results. The user appreciates the feedback and will continue posting progress.

community So I was wondering what stack are we on boys? 🤔

in Satire 475 upvotes 1 year ago

Treatments for hair loss, including microneedling, finasteride, minoxidil, dutasteride, RU-58841, pyrilutamide, pumpkin seed oil, rosemary water, orchiectomy, and estrogen.

community My progress for 1 year minoxidil and dutasteride mesotherapy

in Progress Pictures 101 upvotes 2 years ago

A user's progress using minoxidil and dutasteride mesotherapy to treat hair loss, with advice from other users on whether or not to continue the treatment. Suggestions included trying oral treatments such as finasteride and RU58841, and considering a hair transplant for more significant results.

community Results so far on Finasteride and biotin

in Progress Pictures 144 upvotes 2 years ago

The conversation is about someone experiencing significant hair regrowth after 23 days on Finasteride and Biotin, with others suggesting additional treatments like Minoxidil and microneedling. Some doubt the speed of hair growth, while others believe Biotin isn't contributing to the results.