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GlossaryCatagen Phase (catagen transition)

hair growth stops and follicles shrink, lasting about 2-3 weeks

The Catagen Phase, also known as the Transitional Phase, is a short period in the hair growth cycle that lasts about 2-3 weeks. During this phase, hair growth stops, and the hair follicle shrinks and detaches from the dermal papilla, effectively transitioning the hair from the growth phase (Anagen) to the resting phase (Telogen). This phase is crucial for the renewal of hair follicles and the overall hair growth process.

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community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

in Research/Science 198 upvotes 3 days ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

community IGFBP‐rP1 is a potential therapeutic target in androgenic alopecia

in Research/Science 13 upvotes 1 month ago

IGFBP‐rP1 shows potential for treating androgenic alopecia by influencing hair cycle transitions. Increasing IGF-1 levels may have similar effects to Minoxidil and 5-AR inhibitors in reducing hair loss.

community A side to side comparison, two and half months apart

in Progress Pictures 223 upvotes 4 months ago

A user shared progress pictures showing hair improvement after using oral finasteride and topical minoxidil for two and a half months. They are considering a hair transplant but are advised to wait for full results from the treatments.

community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 2 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.

community Getting hit hard by the shed….

in Progress Pictures 86 upvotes 6 months ago

A user is experiencing significant hair shedding after starting a treatment regimen of 1mg oral finasteride, 3mg oral minoxidil, 2.5mg biotin, and vitamins. Despite the shedding, they remain optimistic and plan to continue the treatment for a year before making any conclusions.

community My scalp punch biopsy results🤔?

in Female 9 upvotes 1 year ago

Female using Rogaine foam for hair loss had scalp punch biopsy, diagnosed with Androgenetic Alopecia (AGA). Doctor recommended starting Spironolactone 50mg.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community 5 Month Dutasteride Progress Before and After

in Progress Pictures 173 upvotes 1 year ago

A user experiencing significant hair loss started using Dutasteride, a drug typically used for prostate issues, and noticed a positive change in hair thickness and volume after 5 months. Other users in the conversation also shared their experiences and observations with Dutasteride, with one mentioning additional use of oral Minoxidil.

community My journey from Norwood 3.5/4 to Norwood 0

in Transplants 248 upvotes 9 months ago

A user's hair regrowth journey involved a hair transplant and using RU58841, finasteride, and minoxidil, with side effects managed by other medications.

community HMI-115 update: Chime Biologics and Hope Medicine Enter Manufacturing Agreement to Speed up the Launch of First-in-class Antibody Drug HMI-115 Targeting Endometriosis and Androgenic Alopecia

in Research/Science 112 upvotes 1 year ago

Chime Biologics and Hope Medicine are speeding up the launch of a first-in-class antibody drug, HMI-115, for endometriosis and androgenic alopecia. The treatment involves a series of subcutaneous injections, has shown promising results in phase 1, and continues to promote hair regrowth even after the treatment is stopped.

community Pyrilutamide update: three months

in Update 32 upvotes 1 year ago

A user's 3-month experience with pyrilutamide to reduce hair shedding, and how it may not be strong enough to stop the thinning of their hairline. Other users mentioned the effectiveness of minoxidil and finasteride for treating hair loss.

community Anyone Else Balding but Never Notice Shedding?

in Chat 8 upvotes 1 month ago

A user discusses their experience with hair loss, noting they don't notice shedding despite using finasteride, minoxidil, and tretinoin. Others share similar experiences, suggesting that shedding varies and may not occur for everyone using these treatments.

community HLT Megathread on HMI-115 (key takeaways in comments)

in Research/Science 39 upvotes 1 year ago

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

community Coegin Pharma to release Follicopeptide (FOL005) by Q2 2025

in Treatment 118 upvotes 3 months ago

Follicopeptide (FOL005) by Coegin Pharma will launch as a cosmetic hair growth treatment by Q2 2025, showing similar efficacy to finasteride. Users discuss the benefits and skepticism of releasing hair loss treatments as cosmetics rather than drugs.

community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

in Research/Science 92 upvotes 2 years ago

The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

community TDM-105795, a new hair loss treatment that actually works!

in Treatment 44 upvotes 10 months ago

A new hair loss treatment called TDM-105795 is discussed as a potential replacement or add-on to Minoxidil. Users express hope for new effective treatments.

community Progress with 6 Years fin and a FUT (2017 vs 2023)

in Is this regrowth? 210 upvotes 1 year ago

The post discusses a user's six-year progress with finasteride and a Follicular Unit Transplant (FUT) for hair loss. The user shared before and after photos in reverse order, leading to confusion, but overall, the community responded positively to the user's hair regrowth.

community Sandalore: a scientific homemade approch

20 upvotes 6 years ago

The post discusses using Sandalore as a potential hair loss treatment, emphasizing precise measurements and safe handling. The user compares Sandalore's effects to Minoxidil and mentions preparing a solution with ethanol and DMSO.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 667 upvotes 2 months ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community 8 months post HT: weird asymmetrical shedding/recession?. Dr not 100% sure cause. Theories??

in Transplants 8 upvotes 3 months ago

8 months post hair transplant, OP experiences asymmetrical shedding despite using finasteride and starting minoxidil. The doctor suggests it might correct itself or be due to transplant trauma, recommending a wait-and-see approach.

community Losing gains from 7 months of oral min, fin, dut.

in Update 66 upvotes 1 year ago

A user reported losing hair after 7 months of using oral minoxidil, finasteride, and dutasteride, but others reassured that this is likely just a shedding phase where old hairs fall out to make way for new growth. Some users experience sheds every 7-8 months and suggest staying consistent with treatment.

community 2 months topical dutasteride plus minoxidil, very happy with the results!

in Finasteride/Dutasteride 337 upvotes 3 years ago

A user's success in treating their hair loss with 2x daily topical dutasteride and minoxidil, as well as the potential for using less frequent application of topical dutasteride due to its long half-life.

community Fevipiprant 2019!

17 upvotes 8 years ago

The conversation discusses Fevipiprant, an asthma drug that may block CRTH2 and potentially stop male pattern baldness (MPB) without inhibiting DHT. It also mentions the use of finasteride and dutasteride for hair loss.

community Why HMI115 should work if it doesn’t affect dht?

in Research/Science 16 upvotes 1 year ago

Hair growth can be induced without stopping DHT, as seen with Minoxidil. HMI115 may work by promoting follicle growth, not targeting the root cause of hair loss (DHT).

community Is it possible to create an estrogen mesotherapy/topical that doesn't go systemic?

in Research/Science 6 upvotes 1 month ago

The conversation discusses the potential of using topical estrogen treatments for hair loss without systemic absorption, highlighting challenges and possible solutions like using estriol. It also mentions other treatments like topical finasteride, microneedling, and scalp massage, while noting the limitations and side effects of current options.

community Spironolactone topically with a try ?!

in Research/Science 1 upvotes 10 months ago

A 30-year-old male is considering using dutasteride and fluridil for hair loss maintenance and is curious about the effectiveness of topical spironolactone, as he cannot take finasteride. He is also planning a hair transplant.

community Tretinoin, any good, what’s your experience

in Research/Science 21 upvotes 6 months ago

The conversation discusses using tretinoin for hair loss and skincare. Users share experiences, noting tretinoin's effectiveness in combination with minoxidil for hair and its proven benefits for anti-aging skincare.

community DHT/Testosterone levels in scalp Fin VS Dut.

in Finasteride/Dutasteride 60 upvotes 5 months ago

Dutasteride raises scalp testosterone by 99%, which may not be ideal for those sensitive to all androgens. Some argue finasteride's balancing act might be better, while others believe dutasteride is superior for hair regrowth.

community Possible topical option for preventing BDNF-related hair loss

in Research/Science 7 upvotes 1 year ago

The conversation discusses hair loss linked to BDNF-increasing nootropics like Semax and Lions Mane. Suggested topical treatments include capsaicin, beta-glucan, and ginseng to counteract TGF-B activation.

community Opinions on this study for Triphasic Progressive by Rene Furterer

in Research/Science 14 upvotes 1 year ago

The user shared their 5-year hair loss journey, initially using a product called Triphasic Progressive by Rene Furterer, which gave good results. Later, they switched to FDA-approved medications finasteride and minoxidil, which also helped, but they noticed the most significant progress with Triphasic. They're considering trying it again if minoxidil doesn't show improvements.