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A 22-year-old male is not seeing hair regrowth after using minoxidil and finasteride for a year and additional treatments for three months. Suggestions include improving scalp absorption with sea salt and trying a lipid-based solution, microneedling, and possibly switching to dutasteride if no improvement after 1-2 years.

A user shared progress pictures and discussed their hair loss treatment, including using Hims spray with finasteride, oral finasteride, castor oil, and derma rolling. They reduced their Hims spray dose to every other day to minimize finasteride absorption into the bloodstream.

A user found that scalp itch might be linked to inflammation rather than DHT alone and noticed hair improvement with certain cancer drugs. They also discovered that black seed oil relieved their scalp itch and are experimenting with a mix of essential oils for dry scalp, questioning if oils affect minoxidil absorption.

User experienced hair growth after 6 months using microneedling, minoxidil, ketoconazole, and biotin. Commenters suggest adding finasteride to treatment for better results and preventing further hair loss.

Users discuss waiting for new hair loss treatments and share struggles with side effects from current options like Minoxidil and Finasteride. They express hope for Pyrilutamide and CosmeRNA to provide better solutions.

User has been using Minoxidil twice daily for a year with good results and is considering adding a 1.5mm titanium derma roller for better hair regrowth. They seek advice on the best derma roller size and frequency of use, suggesting once a month or every 3-4 weeks.

A user ordered a topical dutasteride gel with tretinoin for hair loss after unsatisfactory results with minoxidil and finasteride. Another user shared their experience with the same product, noting its pleasant smell and feel but difficulty in application and uncertainty about its absorption and frequency of use.

The user has been using finasteride and minoxidil for 5 years to prevent hair loss and is considering adding dutasteride for regrowth or opting for a hair transplant. Suggestions include trying dutasteride, oral minoxidil, microneedling, and possibly a hair transplant for better results.

The user is disappointed with their hair loss treatment results using Minoxidil, dermastamping, and ketoconazole shampoo. They are advised to add Finasteride or Dutasteride to block DHT for better results.

FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

A 47-year-old male experienced significant hair loss after losing 37 kg in 6 months on a low-carb diet and started taking biotin, zinc, iron, selenium, and spectral dcn-n. Replies suggest that while carbs are not directly needed for hair growth, they help regulate hormones and nutrient absorption, and rapid weight loss can also contribute to hair loss.

Optimal microneedling routine is 1.25mm once a week with Dr Pen 36 needles. Applying Minoxidil right after microneedling may increase systemic absorption risk.

A user shared their 4.5-month hair transformation using a homemade topical solution with 5% minoxidil and crushed finasteride pills, applied twice daily with weekly microneedling. They plan to switch to once-daily application with tretinoin gel to enhance absorption.

The user "_Mad_Jack_" shared their progress pictures of using topical finasteride and minoxidil for 11 months. They experienced good hair retention and increased overall hair count, but no regrowth of the hairline. They are considering switching to oral finasteride and microneedling for better results. Testicular pain was a side effect experienced during the treatment. Another user mentioned getting a hair transplant to cover their crown.

User tried topical and oral finasteride and oral minoxidil for hair loss without success. ButterscotchSea3159 suggests using Dutasteride, oral minoxidil, ketoconazole shampoo, microneedling, and possibly RU for better results.

The conversation discusses the effectiveness of anti-androgens for hair loss, with a preference for topical treatments like RU58841 over oral options due to better scalp concentration and fewer side effects. Topical finasteride at 0.1% may provide some results, especially when combined with a topical androgen receptor antagonist like RU58841.

The conversation discusses hair loss and treatments, with users suggesting the original poster's hair has receded despite using a dermaroller and RU58841 for two months. Many recommend starting finasteride and minoxidil for better results.

This conversation is about how topical treatments for hair loss, such as Minoxidil and Finasteride, can be replaced by drinking oral versions of the same medications to achieve better results with less hassle. Some users have already been doing this with positive results.

Kintor Pharmaceutical's Phase 2 results with the drug Pyrilutamide, a potential alternative to 5-ARI drugs like Finasteride and Dutasteride but without the side effects. It could be used in combination with other topical treatments such as Minoxidil. The safety of the drug has been demonstrated in 6 months of use, however there are still questions about long term efficacy and systemic absorption.

Hair loss treatments discussed include Minoxidil, Finasteride, and RU58841. Pyrilutamide Phase 2 results are expected in June 2022, with hopes for a better alternative to current treatments.

Pyrilutamide Phase 3 approved, starting early 2022 with 416 subjects for 24 weeks. Drug potentially better than RU and Breezula, with some users reporting no side effects.

User discusses topical liposomal finasteride for hair loss, hoping to avoid breast growth side effect. Conversation includes using minoxidil, fluridil, and dermarolling, and mentions minimal systemic absorption of liposomal finasteride.

User tried DIY Dutasteride Mesotherapy for hair loss due to unsatisfactory Finasteride results. Used mesotherapy injection gun and liquid dutasteride for better results and fewer side effects.

The conversation provides advice on using derma rollers, stamps, and pens for hair loss, detailing types, usage, cleaning, depth, frequency, and caution with topicals like minoxidil. The user plans to replace a roller with a pen for better accuracy and safety, and uses a castor oil/rosemary oil mix post-needling.

A user's two-year hair regrowth journey using 0.5 mg Dutasteride, 5mg oral Minoxidil, 0.75ml of 8% RU58841, and Nizoral shampoo a few times a week. Other users suggest adding microneedling and topical Minoxidil for better results.

The user has been using Hims finasteride and minoxidil spray, nizoral shampoo twice a week, and a daily biotin gummy for 90 days to treat hair loss. The user and others discuss the cost, dosage, and effectiveness of the treatment, with some suggesting cutting hair short for better results.

Kintor's GT20029, a treatment for hair loss, has completed Phase 1 successfully, showing promise as an androgen receptor degrader that could potentially regrow hair. It is considered more effective than Pyrilutamide, with infrequent dosing and minimal systemic absorption.

The conversation discusses a prescribed hair loss treatment combining 12.5% minoxidil with tretinoin, azelaic acid, and topical finasteride, costing $55 a month. One user criticizes the packaging for degrading tretinoin, another suggests it's an overpriced option and recommends topical dutasteride as an alternative due to its higher molecular weight and lower systemic absorption.

A 25-year-old woman is experiencing hair loss and has started microneedling with a 0.5mm roller, applying a mix of essential oils overnight. She questions whether to switch to a 1.5mm roller and the best order for her routine, while a reply suggests using Minoxidil for better results.

Treatments for hair loss, including finasteride, dutasteride, minoxidil, ketoconazole, microneedling, and low level laser light therapy, which aim to reduce DHT production, increase cell absorption and blood flow, and stimulate epidermal stem cells. It also stresses the importance of patience when using these treatments.