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GlossaryATP-sensitive potassium channels

regulate potassium ion flow based on cellular energy levels

ATP-sensitive potassium channels (KATP channels) are specialized proteins found in the cell membrane that help regulate the flow of potassium ions in and out of the cell. These channels are sensitive to the levels of ATP (adenosine triphosphate), the cell's main energy currency, and they open or close in response to changes in ATP concentration. This mechanism allows the channels to play a crucial role in linking the cell's metabolic state to its electrical activity, which is important in various physiological processes such as insulin release, muscle contraction, and neuronal activity.

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community If PP405 goes systemic this would be quite catastrophic

in Research/Science 3 upvotes 3 months ago

Concerns about the potential systemic effects and safety of PP405 for hair loss, with discussions on its comparison to existing treatments like finasteride and minoxidil. Users express skepticism about untested research chemicals and emphasize the importance of clinical trials to ensure safety and efficacy.

community My good/bad experience with Creatine

in Treatment 23 upvotes 1 week ago

Creatine may cause increased hair shedding in some individuals, especially those with androgenetic alopecia (AGA), despite its physical performance benefits. Many users report stopping creatine to reduce hair loss, while others believe the effects are anecdotal or due to other factors like increased physical activity.

community 5 month update, minoxidil and finasteride

in Progress Pictures 717 upvotes 2 months ago

The user is happy with hair regrowth after 5 months using topical minoxidil twice daily, oral finasteride once daily, derma stamping weekly, and Watermans shampoo. They noticed darker hair and stopped using creatine, suspecting it worsened hair loss.

community Have you seen anybody using natural remedies and succeed?

in General 116 upvotes 2 months ago

Natural remedies like onion juice and pumpkin seeds are discussed for hair loss. Minoxidil, finasteride, and RU58841 are also mentioned as treatments.

community 41m - Topical fin/min, micro needling 1.5mm every 2 weeks, Nizoral 2% shampoo occasionally

in Progress Pictures 302 upvotes 3 months ago

A 41-year-old man experienced significant hair regrowth using topical finasteride (0.025%), minoxidil, microneedling every two weeks, and occasional Nizoral 2% shampoo. He advises against using creatine due to personal experience with increased hair shedding.

community Interesting article links major MPB theories to western diet (and life-style)

in Research/Science 58 upvotes 5 months ago

Poor diet and lifestyle contribute to male pattern baldness. Treatments like Minoxidil, dietary changes, and lifestyle adjustments may help slow hair loss.

community Progress (or lack there of) - Finasteride 9 months

in Progress Pictures 12 upvotes 5 months ago

The user has been using finasteride, minoxidil, and Nizoral for 9 months with little progress in hair regrowth and is considering switching to dutasteride. They experience daily scalp pain and anxiety, and are exploring other treatments like Head & Shoulders and consulting a dermatologist.

community My dermatologist screwed me over methinks (18M)

in Minoxidil 12 upvotes 9 months ago

A user discusses their hair thinning journey, starting minoxidil at 16, switching treatments, and experiencing significant shedding after resuming minoxidil. They are now using minoxidil daily and considering PRP if shedding continues, while also planning lifestyle changes to improve their condition.

community Opinions on this study for Triphasic Progressive by Rene Furterer

in Research/Science 14 upvotes 1 year ago

The user shared their 5-year hair loss journey, initially using a product called Triphasic Progressive by Rene Furterer, which gave good results. Later, they switched to FDA-approved medications finasteride and minoxidil, which also helped, but they noticed the most significant progress with Triphasic. They're considering trying it again if minoxidil doesn't show improvements.

community Who's tried these topical solutions?

in Treatment 10 upvotes 1 year ago

Topical melatonin, caffeine, and adenosine have shown impressive results in increasing hair density by 55% in 8 weeks, according to a Medium article.

community Why creatine and gym cause MPD

in Finasteride/Dutasteride 2 years ago

Gym and creatine can cause hair loss by increasing testosterone and androgenic activity. DHT blockers may help some, while others need androgen suppression with topical AA like RU or Pyri.

community Anything you use without scientific backing, just trusting your gut?

in Research/Science 13 upvotes 2 years ago

The conversation discusses using peppermint oil for hair loss, with one user applying it undiluted to the scalp and another combining it with finasteride and microneedling. Some believe in its effectiveness despite limited scientific evidence, and also mention rosemary oil as potentially beneficial.

community Dutasteride has only made things worse

in Finasteride/Dutasteride 13 upvotes 2 years ago

A user's experience with hair loss treatments, specifically finasteride and dutasteride; how the user experienced prolonged worsening of their hair despite taking both medications; and finally, that this story is consistent with other experiences.

community As in this research, i have seen many who advise a regular use of VitaminD, even if you are not deficient. Once i had read in tressless that mpb and Vitamin D might have a correlation. So could it be an a benefit to add this to your ongoing treatment plan?

in Research/Science 83 upvotes 4 years ago

People discussed using vitamin D supplements for hair loss, with some also using steroid injections, pumpkin seed oil, saw palmetto, and zinc. Despite supplementation, one user noted no improvement in hair condition, but acknowledged the general health benefits of addressing vitamin D deficiency.

community Nice product I discovered, thought I would share.

in Treatment 460 upvotes 2 weeks ago

A product that makes hair look thicker and healthier without promoting regrowth. Discussions include treatments like minoxidil, finasteride, red light therapy, and a serum with caffeine and peptides, with mixed effectiveness opinions.

community Fresh off the press: Dutasteride may cause chronic infertility

in Research/Science 635 upvotes 1 month ago

Dutasteride may cause chronic infertility by reducing semen volume and motility, with concerns about irreversible prostate fibrosis. Users consider switching to finasteride or using treatments like minoxidil and microneedling, weighing hair preservation against fertility.

community 30-Min Dermatology Visit – Best Questions to Ask About Balding? ( 175$ )

in Treatment 6 upvotes 1 month ago

The conversation discusses hair loss treatments, focusing on finasteride, minoxidil, and other options like PRP and ketoconazole. It highlights the importance of asking specific questions during a dermatology visit to determine the cause of hair loss and appropriate treatments.

community Balding Sucks. Balding Young is Awful. Balding Young and being Unable to Grow any Facial Hair is Hell on Earth

in Update 339 upvotes 2 months ago

A 25-year-old is frustrated with hair loss and inability to grow facial hair despite using oral finasteride and minoxidil for over a year. Suggestions include trying topical treatments, considering a hair system, or seeking professional help for mental health.

community Last Post Before I Switch Back to Finasteride From Dutasteride

in Finasteride/Dutasteride 29 upvotes 3 months ago

The user plans to switch from dutasteride back to finasteride due to worsening hair loss, possibly due to increased scalp testosterone. Others report mixed results with both treatments, showing individual variability.

community How ET-02 Works. Also no proof that it's better than Minoxidil. At least for now.

in Research/Science 44 upvotes 3 months ago

ET-02, a PAI-1 inhibitor, is not proven to be more effective than Minoxidil for hair loss. Other treatments like finasteride, dutasteride, PP405, and AMP-303 are also discussed, focusing on cellular senescence and oxidative stress.

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

in Research/Science 2 upvotes 4 months ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

in Research 413 upvotes 4 months ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 6 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Solving Hair Loss with Research at MIT

in Research/Science 594 upvotes 6 months ago

Hair loss treatments like minoxidil, finasteride, TDM-105795, and PP405. MIT is hosting a hackathon to find innovative hair loss solutions.

community Why you shouldn’t trust “progress” pictures.

in Chat 388 upvotes 6 months ago

Hair loss progress pictures can be misleading due to differences in lighting, hair length, and wetness, making it hard to accurately assess changes. Treatments mentioned include minoxidil and finasteride, with some users expressing skepticism about their effectiveness.

community I have hairy legs and arms, and the hair grows 2+ inches long- Can I transplant it all to my head?

in Transplants 442 upvotes 8 months ago

The conversation discusses the possibility of transplanting leg and arm hair to the scalp for hair loss treatment. Minoxidil is mentioned as a potential aid for hair growth, but concerns about the effectiveness and appearance of body hair on the head are raised.

community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001) Pt 2

in Research/Science 479 upvotes 9 months ago

Sugary beverages increase the risk of pattern hair loss in men by 57%. Treatments discussed include Minoxidil, finasteride, and RU58841.

community NBC News: Finasteride is increasingly being prescribed even before baldness begins

in Finasteride/Dutasteride 360 upvotes 10 months ago

Finasteride is increasingly prescribed to young men to prevent hair loss, with many users expressing regret for not starting sooner. The conversation highlights the preference for Finasteride, Dutasteride, and Minoxidil over other treatments.

community 36 MTF - Born balding, went bald, recovering hair

in Journals / Progress Pictures 563 upvotes 10 months ago

A 35-year-old MTF individual shared their hair recovery journey, using Minoxidil, Dutasteride, Estradiol, Spironolactone, Microneedling, and Exosomes. They recently had a hair transplant and are documenting the healing process.

community Physio-metabolic method (antiandrogen, minoxidil, leg training and cold)

in Treatments 309 upvotes 10 months ago

The method combines finasteride, minoxidil, intense leg exercises, and cold exposure to treat androgenetic alopecia. It aims to boost metabolism and reduce androgenic effects, enhancing hair growth.