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GlossaryAndrogen Receptor Antagonists (antiandrogenic agents)

block male hormones like testosterone from affecting tissues

Androgen Receptor Antagonists, also known as antiandrogens, are medications that block the action of androgens, which are male sex hormones like testosterone. These drugs work by binding to androgen receptors, preventing androgens from exerting their effects on tissues, and are commonly used in the treatment of conditions like prostate cancer, androgenic alopecia (male-pattern baldness), and certain types of acne.

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community List of natural supplements I have tried which did not slow my MPB

in Chat 32 upvotes 7 months ago

A user shared a list of natural supplements they tried that did not stop their male pattern baldness (MPB), including vitamin D, biotin, and various oils. The conversation includes skepticism and jokes about one of the methods, injecting jellyfish mucus into testicles, and mixed opinions on the effectiveness of natural treatments.

community Why haven’t we seen anything about this

in Research/Science 18 upvotes 4 years ago

A double blind, placebo-controlled study that looked into the potential effectiveness of topical fluridil for treating male androgenetic alopecia, showing increased anagen to telogen ratios with no reported side effects on libido or sexual performance.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 1 month ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community 5 months on Spiro and 6 weeks on oral Monoxidil. Beyond thrilled with the results so far

in Female 190 upvotes 4 years ago

Treatments for hair loss, specifically the use of Spironolactone (Spiro) and oral Minoxidil, as well as Finasteride and RU58841.

community The story of RU58841/ PSK3841

in Research 622 upvotes 3 months ago

RU58841, a potential hair loss treatment, was not commercialized due to marketability issues and lack of long-term safety data. Concerns about its formulation and delivery methods further complicate its use.

community Ru, Stemoxydine or Alfatradiol? What has your experience been with any of these 3?

in Treatment 3 upvotes 1 year ago

The user is seeking advice on which treatment to add to their current regimen for male pattern baldness. They have previously tried Dutasteride, Nizoral, and oral Minoxidil, but experienced continued hair loss. They are specifically asking for experiences with RU58841, Stemoxydine, or Alfatradiol.

community Clotrimazole a better anti-androgen than Ketoconazole?

in Research/Science 1 upvotes 4 years ago

Clotrimazole may inhibit testosterone better than Ketoconazole. The user considers applying Clotrimazole cream on the scalp for hair loss.

community Have you guys heard about topical melatonin?

in Research 7 upvotes 4 years ago

Topical melatonin may improve hair density and thickness, and reduce hair loss and seborrhea with no significant side effects. The user made their own melatonin solution for hair treatment.

community Have you ever seen a "back from the dead" result that DIDNT use microneedling?

in Microneedling 33 upvotes 3 weeks ago

Some users report significant hair regrowth without microneedling, using treatments like finasteride, minoxidil, and dutasteride. Others believe microneedling enhances results, but opinions vary on its necessity.

community Everyone seems to be looking for an antiandrogen as an add on. But what about Estradiol & its derivatives ( excluding the low concentraion alfatradiool ) being used. Anyone has an experience with this ? Anything that won't cause feminization in the process ?

in Chat 6 upvotes 2 months ago

The conversation discusses using estradiol and its derivatives for hair loss without causing feminization. Users mention alternatives like alfatradiol, topical 17b-Estradiol, and DIM (Diindolylmethane).

community New Study - Flavonoids More Effective Than Finasteride?

in Research/Science 148 upvotes 11 months ago

A recent publication suggests that the flavonoids eriocitrin and silymarin may be more effective than finasteride in binding to the enzyme responsible for hair loss. People in the conversation are skeptical about the effectiveness and safety of these flavonoids until tested on humans, and some discuss their personal experiences with other treatments.

community Sweet Lord my DHT itch is finally gone

in Chat 49 upvotes 1 year ago

Hair loss itch stopped by adding RU58841 to treatment. Topical Finasteride and Pyrilutamide also mentioned as potential itch solutions.

community Pyrilutamide - your experience?

in Product 12 upvotes 1 year ago

The conversation is about the lack of improvement in hair loss after using Pyrilutamide for 14 weeks, with the original poster unable to use Finasteride due to depression. Replies suggest that Pyrilutamide, like RU58841, may not work for everyone, and a more potent drug is being developed by Kintor.

community Topical spironolactone - anti androgen

in Research/Science 9 upvotes 2 years ago

User asks about topical spironolactone experience. Two studies show it as promising anti-androgen treatment, with 5% cream available on Minoxidilmax website.

community Start taking care of your skin and hair loss TODAY! I was telling myself I didn’t care, but I think the difference in my facial expression says it all. Take action asap before more permanent damage is done. I hope I can inspire some of you, because it’s so worth it. Not for others, for yourself! <3

in Progress Pictures 583 upvotes 2 years ago

User shared progress in treating hair loss and improving skin, using treatments like finasteride, minoxidil, RU58841, tretinoin, microneedling, and skin care regimen. Others commented on the impressive results and asked about costs and side effects.

community Anyone wanna try and interview the developers of RU?

in Research/Science 82 upvotes 3 years ago

The conversation discusses arranging an interview with the developers of RU58841 to clarify its safety and reasons for halted research, with some users expressing concerns about potential risks and others citing financial reasons for the discontinuation of studies. Specific treatments mentioned include RU58841, minoxidil, and finasteride.

community My boy Saul Goodman was on Minoxidil tabs too

in Satire 1888 upvotes 3 months ago

Saul Goodman was humorously depicted using high doses of minoxidil, finasteride, and spironolactone for hair loss. The conversation jokes about the unrealistic dosages and their potential side effects.

community Obviously, all of us who are serious take antiandrogens and growth stimulants - what else are you doing lifestyle wise, dietary wise, and regiment wise to maximize your results?

in Treatment 21 upvotes 4 months ago

The user follows a hair loss treatment routine including Propecia, oral minoxidil, ketoconazole, and plans to switch to dutasteride. They also focus on lifestyle changes, dietary supplements, and are considering laser therapy.

community Physio-metabolic method (antiandrogen, minoxidil, leg training and cold)

in Treatments 309 upvotes 5 months ago

The method combines finasteride, minoxidil, intense leg exercises, and cold exposure to treat androgenetic alopecia. It aims to boost metabolism and reduce androgenic effects, enhancing hair growth.

community ~1 year using rosemary shampoo (trigger warning)

in Progress Pictures 158 upvotes 7 months ago

A user reported hair thickening and a stronger crown after using rosemary shampoo for about a year, with progress pictures as evidence. Some commenters discussed the effectiveness of natural treatments versus pharmaceutical options like Minoxidil and Finasteride.

community 6 months progress no fin 27m topical foam minox

in Progress Pictures 250 upvotes 1 year ago

The user has been using 5% Minoxidil foam twice daily, microneedling every two weeks, and Nizoral 2% shampoo weekly for hair loss treatment. They've seen improvements in their hairline and eyelashes, and are considering adding finasteride to their regimen.

community Can someone explain why it's "dumb" to just drink topical liquid minoxidil?

in Minoxidil 27 upvotes 1 year ago

The conversation discusses the risks and methods of ingesting liquid minoxidil for hair loss. Concerns include dosing accuracy, safety of ingredients, and potential side effects compared to using oral minoxidil tablets.

community A hair model who does beauty ads and has 3 million followers claims he went from almost a Norwood 3 to a perfect hairline in 8 months on only Minoxidil and Rosemary oil. Curious, what are people’s thoughts?

in Chat 1 year ago

This conversation discusses the results of a model who claims he went from almost a Norwood 3 to a perfect hairline in 8 months using only Minoxidil and Rosemary oil. The replies suggest that this could be realistic but long-term results would require additional treatments like finasteride or other medications to prevent further hair loss.

community Kintor Phase 2 Results released KX-826 (pyrilutamide)

in Research/Science 454 upvotes 2 years ago

Kintor Pharmaceutical's Phase 2 results with the drug Pyrilutamide, a potential alternative to 5-ARI drugs like Finasteride and Dutasteride but without the side effects. It could be used in combination with other topical treatments such as Minoxidil. The safety of the drug has been demonstrated in 6 months of use, however there are still questions about long term efficacy and systemic absorption.

community PYRILUTAMIDE KX-826 experience

in Research/Science 98 upvotes 2 years ago

A user's experience with the hair loss treatment Pyrilutamide KX-826, which has resulted in some side effects and shedding. The conversation also includes advice for baseline pictures and trying treatments for at least 6 months.

community I am having Success with RU58841 and 1mm Derma Roller

in Microneedling 19 upvotes 2 years ago

A user reported success with RU58841 and a 1mm derma roller for hair regrowth, noting significant improvement in hair density and reduced scalp visibility. They also mentioned using minoxidil and black castor oil in the past, with mixed results.

community Melatonin a possible tool to help fight AGA hair loss.

in Research/Science 54 upvotes 3 years ago

Topical melatonin may help reduce hair loss and increase hair thickness in people with androgenetic alopecia (AGA), with some studies showing positive results. It can be mixed with minoxidil for application, and its effectiveness might be enhanced when used with micro-needling, but results may vary among individuals.

community The Big Fat Layer II

in Research/Science 26 upvotes 3 years ago

Hair loss treatment should target dermal white adipose tissue (DWAT) to restore hair follicles. Potential remedies include tocopherol (vitamin E), botox, rosiglitazone, niacin, kojyl cinnamate esters, and ADP355.

community Would Fluridil and Alfatradiol work effectively in conjunction with each other?

in Treatment 9 upvotes 4 years ago

Whether using both Fluridil and Alfatradiol together could be more effective than either one alone as a hair loss treatment, given their different mechanisms of action.

community DHT levels after 4 weeks of Fina and 8 weeks of Fina + 4 weeks of Duta

in Update 36 upvotes 5 years ago

The user reported early stage diffuse hair thinning and increased DHT levels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.