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GlossaryAntiandrogen Therapy (Antiandrogen Drugs)

reduces or blocks male hormones to treat certain conditions

Antiandrogen Therapy, also known as androgen deprivation therapy (ADT), is a treatment that reduces the levels or blocks the effects of androgens (male hormones like testosterone) in the body. This therapy is commonly used to treat conditions like prostate cancer and androgenic alopecia (male pattern baldness) by slowing the growth of cancer cells or reducing hair loss, respectively.

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community RU-58841 Lung Disease Possibility | Chest pain, "heart issues", etc

in Treatment 24 upvotes 8 months ago

Some users of RU-58841 report cardiovascular symptoms like heart palpitations and chest tightness, which may be linked to its metabolites causing lung disease. The safety of RU-58841 is uncertain due to lack of long-term data and concerns about product purity, especially from gray market sources.

community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 1 year ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

community I am putting my hair loss treatment on hold until my mental health is better.

in Update 21 upvotes 2 months ago

OP is pausing hair loss treatments to focus on mental health due to anxiety and side effects from RU58841. They plan to try topical finasteride and minoxidil after recovering from pneumonia.

community Choose your topical antiandrogen and tell me why

in Product 7 upvotes 3 months ago

The conversation is about choosing a topical antiandrogen for hair loss, with options including RU58841, CB0301, Pyrolutamide, Alfatradiol, and Fluridil. Users discuss their preferences and reasons for selecting specific treatments.

community Physio-metabolic method (antiandrogen, minoxidil, leg training and cold)

in Treatments 309 upvotes 5 months ago

The method combines finasteride, minoxidil, intense leg exercises, and cold exposure to treat androgenetic alopecia. It aims to boost metabolism and reduce androgenic effects, enhancing hair growth.

community A topical antiandrogen is very necessary to add to the stack, finastride/Dutastride aren't enough to move the needle.

in Update 1 year ago

User added RU and pyrilutamide for hair growth and noticed more baby hairs. Others suggest sticking with fin and min, while some discuss the user's self-image and hair loss severity.

community Everyone seems to be looking for an antiandrogen as an add on. But what about Estradiol & its derivatives ( excluding the low concentraion alfatradiool ) being used. Anyone has an experience with this ? Anything that won't cause feminization in the process ?

in Chat 6 upvotes 2 months ago

The conversation discusses using estradiol and its derivatives for hair loss without causing feminization. Users mention alternatives like alfatradiol, topical 17b-Estradiol, and DIM (Diindolylmethane).

community has anyone tried rubbing receipt paper on their heads as a free topical antiandrogen?

in Satire 49 upvotes 2 months ago

This post and conversation are about using receipt paper as a satirical treatment for hair loss. Users humorously discuss various absurd methods, including rubbing, ingesting, and making suppositories out of receipts.

community Binding affinity of pyrilutamide!

in Update 168 upvotes 2 years ago

Pyrilutamide, a nonsteroidal antiandrogen drug under development for the potential treatment of androgenic alopecia. The conversation discusses its binding affinity to the androgen receptor and the timeline for possible availability after trials are completed in the United States and China.

community Why isn't fluridil more widely used and known about?

in Treatment 9 upvotes 3 years ago

Fluridil, an antiandrogen that is not widely used or known about due to its expense and lack of availability in the US. It is suggested as a potential alternative for people who don't want to lower their DHT through treatments such as Minoxidil, Finasteride, Nizoral shampoo, and Dermarolling.

community Does Minoxidil make you lose more hair if you stop it?

in Minoxidil 6 upvotes 3 years ago

The conversation is about someone considering using Minoxidil combined with a weak antiandrogen for hair loss, but is concerned about potential increased hair loss if they stop using Minoxidil. They are seeking others' experiences with stopping Minoxidil and the effects on their hair.

community It’s really unfortunate the CB-03-01 is so expensive.

14 upvotes 6 years ago

The conversation discusses the high cost of CB-03-01, a topical antiandrogen for hair loss, which is considered safe and remains localized upon application. It questions whether the expense is justified compared to the lower risks it poses relative to finasteride.

community 3 Months Pyrilutamide(1.5 Months 1% ) + Alfatradiol 0.1% + Minoxidil

in Treatment 99 upvotes 6 days ago

The conversation discusses using Pyrilutamide, Alfatradiol 0.1%, and Minoxidil for hair loss treatment. Pyrilutamide is described as a strong antiandrogen, and Alfatradiol is noted for its effectiveness in inhibiting DHT on the scalp.

community How much would a high dose dutasteride scalp dht inhibition be?

in Finasteride/Dutasteride 10 upvotes 7 months ago

The conversation discusses the potential for high doses of dutasteride to completely inhibit scalp DHT and speculates whether this could cure baldness when combined with a topical antiandrogen. Specific dosages mentioned are 0.5 mg reducing scalp DHT by 55% and 2.5 mg by about 79%.

community Topical androgens for alopecia to treat sebum overproduction on the face

in Product 1 upvotes 8 months ago

The conversation discusses using scalp antiandrogens like RU58841, pyrilutamide, or fluridil on the face to reduce sebum production, noting that clascoterone (winlevi) is an approved facial antiandrogen with underwhelming reviews.

community Topical spironolactone - anti androgen

in Research/Science 9 upvotes 2 years ago

User asks about topical spironolactone experience. Two studies show it as promising anti-androgen treatment, with 5% cream available on Minoxidilmax website.

community Topical bicalutamide vs ru58841

in Female 1 upvotes 2 months ago

A user is seeking advice on making a topical bicalutamide solution as an alternative to RU58841 for hair loss, while already using dutasteride and minoxidil. They are considering crushing bicalutamide pills and adding them to their minoxidil.

community What’s your experience with RU58841?

in Treatment 21 upvotes 1 year ago

People shared mixed experiences with RU58841 for hair loss; one person saw no improvement, another had significant gains and uses it with finasteride, while a third had an allergic reaction to the premixed solution. Some mix RU58841 powder into minoxidil themselves.

community how do RU and topical spironolactone compare?

in Product 6 upvotes 1 year ago

Hair loss treatments RU and topical spironolactone were compared. No specific results or conclusions were provided.

community Breezula - what's the consensus?

in Research/Science 6 upvotes 3 years ago

People are discussing Breezula, a hair loss treatment, with mixed opinions on its value for the cost. Some are interested in it, while others think it's not worth the money.

community Pyrilutamide +Alfatradiol 0.1% , no Hairloss anymore

in Treatment 44 upvotes 1 month ago

OP experienced diffuse thinning for 11 years and used Minoxidil and Finasteride previously. They now use Pyrilutamide 0.5% and Alfatradiol 0.1%, resulting in significantly reduced hair loss.

community Is there any way at all to style what little hair i have left to make it look not awful?

in Transgender 1 upvotes 2 months ago

OP is struggling with hair loss and is seeking advice on styling or treating their hair to look better. They currently use Nizoral and Maui conditioner but are considering wigs due to the lack of improvement.

community Shedding on pyri (KX-826) is this normal?

in Update 8 upvotes 2 months ago

A user experienced increased shedding after adding KX-826 to their long-term finasteride and minoxidil regimen. Another user reported mild side effects from KX-826, such as stomach and testicle pain.

community Found a Pharmacy that will mix me 0.1 % Alfatradiol (Pantostin)

in Treatment 6 upvotes 2 months ago

The user is currently using 0.025% Pantostin but plans to switch to 0.1% Alfatradiol. They will also use high-dose Kx826, high-dose Minoxidil, and aggressive microneedling for hair regrowth.

community Why do I have the feeling that this subreddit is flooded by Kintor employees?

in Chat 132 upvotes 3 months ago

Users discuss aggressive promotion of Koshine 826, suspecting Kintor employees are behind it. Concerns are raised about its effectiveness, with some preferring alternatives like finasteride and minoxidil.

community Adding dut with fin to stop dht itch

in Finasteride/Dutasteride 2 upvotes 3 months ago

A user is seeking advice on adding dutasteride to their finasteride regimen to stop DHT-related scalp itch. They have tried selenium sulfide and ketoconazole shampoos with temporary success.

community RU58841 and impact onmale fertility?

in Chat 2 upvotes 4 months ago

The conversation is about the potential impact of RU58841 on male fertility, specifically regarding sperm concentration, total count, and motility. The user is curious about the likelihood of RU58841 reducing fertility based on its mechanism of action and comparisons to similar substances.

community 12 week progress with HIMS & Micro-needling & Biotin

in Progress Pictures 21 upvotes 9 months ago

User reports 12-week progress with HIMS spray, Minoxidil, micro-needling, and biotin. Notable baby hairs on crown and temples, hoping for further improvement.

community Taking part in a Clascoterone Study

in Treatment 7 upvotes 9 months ago

The conversation is about a person considering participating in a study for Clascoterone, a topical cream for hair loss, and seeking advice on potential side effects. They have mild hair loss and are not currently using other treatments like finasteride.

community How to make a RU58841 solution (50mL 5% strength)

in Research/Science 31 upvotes 10 months ago

The conversation discusses making a RU58841 solution for hair loss prevention and includes personal experiences with using RU58841 and minoxidil for hair regrowth, with a mention of monitoring health effects.