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GlossaryAntiandrogenic Effects (Anti-Androgenic Properties)

inhibit male sex hormones like testosterone

Antiandrogenic effects refer to the actions of substances that inhibit the effects of androgens, which are male sex hormones like testosterone. These substances can block androgen receptors or reduce androgen production, and are often used in treatments for conditions like prostate cancer, androgenic alopecia (male-pattern baldness), and hirsutism (excessive hair growth in women).

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community Keto 2% halted my insane shed immediately

in Ketoconazole 55 upvotes 5 months ago

Ketoconazole 2% shampoo stopped a user's severe hair shedding after just two uses, a result not achieved by finasteride or oral minoxidil. Some users suggest the shampoo's anti-androgenic properties may help with hair loss, while others think the shedding might have stopped naturally or due to the end of a shedding phase.

community Last resort attempt. Studies suggest that finasteride topically actually inhibits up to 52% scalp dht which is smiles to dut 0.5mg daily. This solution contains: fin, min, melatonin and progesterone. Trial started today.

in Research/Science 9 upvotes 2 years ago

The conversation discusses a last-resort hair loss treatment combining topical finasteride, minoxidil, melatonin, and progesterone, with claims that topical finasteride can inhibit up to 52% of scalp DHT. One reply clarifies that progesterone is not an anti-androgen but has anti-androgenic properties because it competes with androgens for receptors.

community How much dht does Nizoral shampoo block?

in Ketoconazole 101 upvotes 2 years ago

Hair loss treatments discussed include Minoxidil, Finasteride, RU58841, and Nizoral shampoo. Nizoral's effectiveness is debated, with some suggesting it works as a weak antagonist for androgen receptors, while others attribute its benefits to anti-fungal and anti-inflammatory properties.

community Best Shampoo Recommendations!!

in Product 12 upvotes 3 months ago

A user is seeking shampoo recommendations for thinning hair that doesn't cause dryness or brittleness. Another user suggests Pura D'or, noting it makes their hair feel better despite thinning, but mentions no shampoo will help with hair loss.

community Could dandruff slow hair growth? (Keto)

in Ketoconazole 1 year ago

The use of minoxidil, finasteride, and Ketoconazole to treat hair loss, with a focus on whether dandruff can slow down hair growth.

community MIN/FIN +Rosemary Mint Oil+Biotin+Vitamins

in Progress Pictures 34 upvotes 4 months ago

The user shared progress pictures showing hair regrowth using Minoxidil, finasteride, rosemary mint oil, biotin, and vitamins. Responses praised the results, though one user doubted the effectiveness of rosemary and biotin.

community How many of you guys use ketoconazole shampoo?

in Ketoconazole 12 upvotes 1 year ago

Using ketoconazole shampoo to help with hair loss, and other treatments such as Minoxidil, finasteride and RU58841.

community Topical quercetin combined with finasteride for max results

in Research/Science 25 upvotes 1 year ago

Combining Finasteride with topical Quercetin, Onion/Garlic juice and Peppermint Oil to reduce Wet Prostate Weight in Rats. Luke10191 asked the user LITUATUI to update them on progress after trying this combination of treatments for hair loss.

community Using Antihypertensive drugs for hair loss

in Chat 6 upvotes 2 years ago

The conversation discusses the potential connection between baldness, heart disease, and high blood pressure. Treatments mentioned include Minoxidil, Spironolactone, and Finasteride.

community Weaned myself off of minoxidil three months after starting HRT

in Transgender 7 upvotes 4 years ago

User stopped using minoxidil due to no growth and greasiness, but experienced hair regrowth after starting HRT with spironolactone and finasteride. Shared before and after photos, showing improvement in hair thickness.

community Fin 3 Month Progress

in Progress 17 upvotes 4 years ago

A 23-year-old noticed crown thinning and started using 1.25mg finasteride, biotin supplements, biotin/collagen shampoo, and 1% nizoral shampoo. After 3 months, they reported improvement and side effects that subsided after 2 months.

community What’s the most effective way to beat Serb Derm?

in Treatment 7 upvotes 2 weeks ago

OP struggles with scalp flakes causing hair loss and has tried Selsun Blue, Ketoconazole, and ZPT Shampoo without success. Suggestions include using salicylic acid shampoo, shaving the head, using Nizoral, and combining treatments like Minoxidil and finasteride.

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 45 upvotes 4 months ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community Hair loss treatments rated (by gpt-4)

in Research/Science 252 upvotes 1 year ago

Rating treatments for hair loss, with the help of GPT-4, according to efficacy, evidence and tolerability; a combination of chemicals from research papers, custom compounds, and some suggestions from other users were included.

community RU58841/Minox/Microneedle(not often) 5 months progress pictures

in Progress Pictures 72 upvotes 2 years ago

A 27-year-old has seen hair regrowth over 5 months using 2ml of 5% minoxidil daily, 50mg of RU58841 daily, and occasional microneedling. Commenters think the results are good and ask about microneedling frequency, needle size, and if ketoconazole shampoo is used.

community The most depressing things about hair loss for me

in Chat 24 upvotes 3 years ago

The emotional impact of hair loss and the risks associated with common treatments such as finasteride, dutasteride, minoxidil, RU58841, and Fluridil. People discussed their personal experiences with these treatments, including potential side effects and lowered fertility. Hair transplants were also mentioned as a possible solution.

community 18 months. Dutasteride, RU58841, Minoxidil, Microneedling, Nizoral, T/GEL

in Progress Pictures 169 upvotes 3 years ago

A 28 year old man's 18-month journey to treat his hair loss with Dutasteride, RU58841, Minoxidil, Microneedling, Nizoral and T/GEL. He experienced some side effects along the way, including translucent semen and scalp less oily.

community Does melatonin dissolve in isopropyl alcohol

in Technology 8 upvotes 1 year ago

The conversation discusses making a topical melatonin solution for hair loss treatment, questioning if isopropyl alcohol can dissolve melatonin. Melatonin is soluble in lipids and alcohol, but it's unstable and should be mixed fresh regularly; it may help hair growth by affecting certain cellular signaling pathways and has anti-androgenic effects.

community to all people who cannot tolerate anti androgens (loe dose topical fin, pyrilutamide, CB) i am getting desperate, looking for a solution

in Research/Science 13 upvotes 1 year ago

The user tried Minoxidil without success, and Finasteride worked but caused sexual side effects even at a very low dose. They are seeking alternative treatments for hair loss as they cannot tolerate anti-androgens and are also in therapy for mental health.

community Anyone here going the “natural” route?

in Scalp Massage 48 upvotes 1 year ago

People discussing their experiences with natural treatments for hair loss, such as essential oils, deep scalp massages, anti-inflammatory measures, and supplements. Most of the replies suggest that these treatments are not effective and recommend medication such as minoxidil or finasteride instead.

community 2.5 months topical minoxidil Progress

in Progress Pictures 441 upvotes 7 months ago

The conversation is about a user's hair regrowth after 2.5 months using topical minoxidil. Some suggest adding finasteride for long-term results, while others share their experiences with side effects or alternative treatments like dermarolling and dietary improvements.

community The Big Fat Layer II

in Research/Science 26 upvotes 3 years ago

Hair loss treatment should target dermal white adipose tissue (DWAT) to restore hair follicles. Potential remedies include tocopherol (vitamin E), botox, rosiglitazone, niacin, kojyl cinnamate esters, and ADP355.

community Taking Charge of Your Hair: The "Big 3 Stack" Explained for 2023

in Research/Science 129 upvotes 1 year ago

The "Big 3 Stack" for hair loss treatment, which includes Minoxidil for hair density improvement, Ketoconazole shampoo for enhancing hair volume and thickness, and Finasteride for blocking hair loss causing hormones. Microneedling can boost Minoxidil's effects.

community 3 months progress with Finasteride 0.5mg/daily, Minoxidil foam5% 2x daily, Stemoxydine 2x daily, Microneedling(M8) 1.5mm 1x per week, Saw Palmetto 400mg/day, peppermint and jojoba oils daily, Ketoconazole 2% shampoo 3x/week, Purador shampoo/conditioner every day.

in Progress Pictures 336 upvotes 2 years ago

Jordan-Iliad has been using a combination of finasteride, minoxidil, stemoxydine, microneedling, saw palmetto, peppermint and jojoba oils, ketoconazole shampoo, and Purador shampoo/conditioner for 3 months to treat their hair loss with stunning results. They have also recently started taking oral minoxidil 1.25mg/day in hopes of achieving even better results over the next 3 months.

community Finasteride 4 months way worse then when I started, shed or am I cooked? 19m

in Progress Pictures 169 upvotes 1 week ago

A 19-year-old experienced worsening hair loss after 4 months on finasteride, despite initial improvement with minoxidil. The consensus is to continue treatment for at least a year, as shedding is common and often temporary.

community Fermented Rice Water ..... ???

in Treatment 112 upvotes 1 year ago

User discusses Fermented Rice Water as a hair loss treatment, with one person claiming it helped regrow their hair. Others share their experiences and opinions, with some skepticism and alternative explanations.

community Hair Remedies that Don't Work for Anybody Seeking Hair Regrowth

in Treatment 6 upvotes 4 years ago

Hair loss treatments discussed include minoxidil, finasteride, and RU58841. Salon products and supplements generally don't work for hair regrowth unless there's a severe nutritional deficiency, while hormonal treatments like estrogen and spironolactone can be effective.

community Testosterone before and after take fin/dut

in Finasteride/Dutasteride 239 upvotes 1 year ago

User experienced 100% testosterone increase after using Finasteride and Dutasteride for hair loss. Some users discuss potential side effects and reasons for the increase.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 735 upvotes 1 year ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community Physio-metabolic method (antiandrogen, minoxidil, leg training and cold)

in Treatments 309 upvotes 3 months ago

The method combines finasteride, minoxidil, intense leg exercises, and cold exposure to treat androgenetic alopecia. It aims to boost metabolism and reduce androgenic effects, enhancing hair growth.