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Glossary Amitriptyline

tricyclic antidepressant used for depression and chronic pain

Amitriptyline, also known by the brand name Elavil, is a tricyclic antidepressant commonly used to treat mental/mood disorders such as depression. It works by affecting the balance of certain natural chemicals (neurotransmitters like serotonin) in the brain, and it can also be prescribed for chronic pain management, migraines, and certain types of nerve pain.

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community Vasodilators, Min, L-arginine, Niacin, Lisinoprol, etc.

in Minoxidil 4 upvotes 3 years ago

The conversation discusses the use of vasodilators like Minoxidil, L-arginine, and Niacin for hair regrowth, with Minoxidil causing intolerable side effects for the original poster. It also highlights that certain medications, including Lisinopril, antidepressants, and statins, can cause hair loss.

community KX-826: My initial thoughts and observations on pyrilutamide...

1 upvotes 1 year ago

The user tried pyrilutamide for hair loss and noticed reduced scalp itch and improved skin but stopped due to mild heart sensations. They plan to update after consistent use, noting improved sleep when applied at night.

community I cannot sleep anymore, what should I do

7 upvotes 1 year ago

Finasteride may cause sleep disturbances, with some users experiencing insomnia. Reducing the dosage, switching brands, or trying Dutasteride might help.

community 2.5 mg/ED dut and 1% pyrilutamide, still getting itch?

1 upvotes 1 year ago

The user switched from finasteride to 2.5 mg dutasteride daily and added 1% pyrilutamide to address persistent scalp itch, but the itch remains. They also use 2% ketoconazole and 2.5% selenium sulfide shampoo for temporary relief.

community Ways to combat insomnia from fin? (I’m not looking to quit!)

4 upvotes 3 years ago

The user is experiencing insomnia after starting finasteride and is seeking solutions without quitting the medication. Suggestions include trying ZMA, maintaining consistent sleep habits, and considering other sleep aids like Nytol or melatonin.

community Antihistamines interaction with Finasteride.

2 upvotes 4 years ago

Stopping antihistamines may resolve neurological side effects when using finasteride. Users experienced muscle aches, headaches, and lethargy when combining the two.

community Does ashwagandha work against finasteride?

in Finasteride/Dutasteride 3 upvotes 7 months ago

Finasteride may cause insomnia, and ashwagandha is suggested to help with sleep issues without significantly affecting testosterone or DHT levels. Users discuss personal experiences with sleep disturbances and suggest consulting a doctor if side effects persist.

community Pyrilutamide for non-5AR users?

in Treatment 10 upvotes 1 year ago

Pyrilutamide is considered by some as an alternative for those avoiding 5AR inhibitors like finasteride and dutasteride, but opinions on its effectiveness vary. Some users report similar results with fluridil and pyrilutamide, while others find pyrilutamide less effective compared to prescription treatments.

community Progressive insomnia (treatment-resistant) due to Finasteride

8 upvotes 4 years ago

A medical student experienced hair loss slowing with Finasteride but developed severe, treatment-resistant insomnia. They tried various medications with little effect, suspecting Post-Finasteride Syndrome, and others suggested the insomnia might be linked to Finasteride's impact on neurosteroids.

community Insomnia and Finasteride

6 upvotes 5 years ago

A user reports experiencing insomnia as a side effect of taking finasteride for hair loss, which takes 1 to 2 hours to fall asleep and results in only about 5 hours of sleep per night. They suspect the cause is related to the downregulation of neurosteroids due to finasteride.

community Finasteride does deplete important nuero-active steroids

11 upvotes 3 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

community What is everyone's assessment of pyrilutamide 1.0% topical as a adjunct treatment?

5 upvotes 3 months ago

The conversation discusses the use of pyrilutamide as an adjunct treatment for hair loss, particularly for those already using finasteride and minoxidil. Users share mixed experiences, with some reporting side effects like numbness and gynecomastia, while others note its potential benefits in reducing shedding and scalp itchiness.

community Pyrilutamide and RU alternatives?

in Treatment 1 upvotes 1 year ago

Pyrilutamide is officially available for purchase, and users suggest Fluridil as an alternative topical anti-androgen. Some users report positive results with pyrilutamide from Koshine.

community pyrilutamide - did anybody had any success on it?

14 upvotes 4 years ago

Potential success with the hair loss treatment Pyrilutamide, and possible group buying opportunities for it along with other treatments such as Finasteride and Minoxidil.

community Taking ashwagandha with finasteride

5 upvotes 1 year ago

Ashwagandha is used to reduce stress and improve sleep, while finasteride is taken for hair loss. Users report positive effects from ashwagandha and mixed results from finasteride, with some experiencing a slight dip in libido.

community Burning sensation and acne along temples accompanied by aggressive recession. On 0.5mg dut, 1.25mg fin EOD, and oral min 5mg daily.

in Finasteride/Dutasteride 2 upvotes 1 year ago

The user experienced temple recession, shedding, and acne while on 0.5mg dutasteride, 1.25mg finasteride every other day, and 5mg oral minoxidil daily. They are considering switching treatments due to worsening symptoms and are contemplating using a topical anti-androgen like RU58841.

community I'm very skeptical about pyrilutamide

in Product 2 upvotes 7 months ago

Pyrilutamide's effectiveness is questioned due to overstated claims and previous trial ineffectiveness, with some users opting for finasteride instead. Despite skepticism, some consider adding pyrilutamide to their regimen alongside treatments like bicalutamide.

community Should I consider switching from Fluridil to Pyrilutmide?

13 upvotes 1 year ago

The conversation is about considering switching from Fluridil to Pyrilutamide for hair loss treatment. Pyrilutamide is suggested to be more effective, with a recommendation to use the 1% variant twice daily.

community I think Ru58841 stopped my itching.

in Chat 4 upvotes 1 year ago

RU58841 stopped scalp itching for the user, providing relief from persistent itchiness associated with hair loss. Some users reported side effects like chest pain, while others found relief with different treatments like mometasone.

community Despite its straightforward mrchanism of action, it looks like pyrilitamide doesn't help regrow hair like finasteride does.

6 upvotes 2 years ago

Pyrilitamide (KX-826) did not show significant improvement in hair count compared to placebo after 6 months. It's unclear if it can maintain hair at baseline.

community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

124 upvotes 2 years ago

The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

community Any way to help Dutasteride depression?

in Finasteride/Dutasteride 1 upvotes 1 year ago

The conversation discusses the user's experience with depression after starting Dutasteride for hair loss, considering whether to lower the dose or try supplements like nootropics. Another user suggests that stopping Dutasteride might not resolve the depression and warns against attributing all issues to the medication.

community What's your thoughts on Pyrilutamide

6 upvotes 9 months ago

The conversation is about using pyrilutamide and RU58841 as topical solutions to prevent hair loss. Pyrilutamide is considered safer but less potent than RU58841, which some users find effective despite potential side effects like heart palpitations.

community How an SSRI seemed to help my hairloss

7 upvotes 3 years ago

An SSRI (paroxetine) reduced hair loss and itching for a user with male-pattern baldness, but liver issues forced discontinuation, leading to increased hair loss and anxiety. The user plans to try other anti-anxiety medications, noting stress and anxiety significantly impact hair loss.

community Testicular Ache

3 upvotes 7 years ago

The user has been taking 0.5 mg of finasteride daily for two months and is experiencing testicular ache, which they believe might be related to the medication. They plan to continue the treatment for a few more months despite the discomfort, hoping the side effects will subside.

community concentration of my finasteride therapy

4 upvotes 1 year ago

The conversation discusses a topical finasteride therapy with hydrocortisone butyrate, estrone base, and breviline. A user suggests oral finasteride as a superior option.

community Does Pyrilutamide lowers sebum production?

2 upvotes 9 months ago

Pyrilutamide's effect on sebum production and scalp inflammation is unclear, with users noting no significant changes. Isotretinoin is mentioned as effective for reducing sebum, while Dutasteride and various shampoos have limited impact on oiliness and seborrheic dermatitis.

community Pyrilutamide (KX-826) progress?

21 upvotes 1 year ago

The user has been using pyrilutamide 0.5% for over 7 weeks, alongside dutasteride, and noticed some hair improvement, particularly at the temples. They plan to continue and possibly try a 1% solution, with no shedding or side effects reported.

community Pyrilutamide vs Topical Finasteride

4 upvotes 10 months ago

Topical finasteride is currently more effective than pyrilutamide for hair loss. Combining treatments like topical finasteride and pyrilutamide may enhance results due to different mechanisms.

community What do you think about pyrilutamide?

in Product 5 upvotes 1 year ago

Pyrilutamide is being discussed as a potential hair loss treatment, but opinions are mixed, with some users skeptical about its effectiveness and the company's credibility. Some users report combining pyrilutamide with other treatments like dutasteride and microneedling, noting improvements, while others remain doubtful.