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      community I got a weird one you guys/gals

      in Chat  10 upvotes 3 months ago
      A 33-year-old man experienced diffuse thinning and hair shedding due to sleep deprivation and low testosterone. After starting hCG treatment, he noticed hair regrowth on his temples.

      community 2 Months Fin/Min/Keto/Micro Needling

      in Microneedling  7 upvotes 3 months ago
      A user shared their 2-month progress using Minoxidil, Finasteride, Keto shampoo, and microneedling for hair growth, reporting positive results. They plan to continue and update the community.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 3 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Bryan johnson mail about his routine

      in Chat  64 upvotes 3 months ago
      A user shared their successful hair loss and gray hair reversal routine, which includes Minoxidil, Cetirizine HCl, Latanoprost, Dutasteride, Melatonin, Caffeine, Tretinoin, Vitamin D3, and Vitamin E. They also use a red light cap, oral Minoxidil, and are developing new treatments.

      community Does pyri/kx826 degrade in exposure to bathroom light?

      in Treatment  5 upvotes 3 months ago
      The conversation discusses concerns about RU58841 degrading when exposed to light and transferring pyri to a dark glass bottle to prevent this. The user keeps the pyri out for only two minutes before storing it in a dark place.

      community fin-min-keto-derma did not work for me. 24 yo

      in Update  16 upvotes 3 months ago
      A 24-year-old tried minoxidil, finasteride, keto shampoo, and derma-rolling for hair loss but saw no improvement and is now at Norwood 5. They feel there's nothing more they can do and are considering going bald despite not liking the look.

      community 8 months into Finasteride and Minoxidil (17M)

      in Is this regrowth?  1 upvotes 3 months ago
      A 17-year-old has been using minoxidil, microneedling, and finasteride for hair loss, with added tretinoin for better absorption. They are seeking opinions on their progress and the use of finasteride as a teenager.

      community 3 months fin/min progress (age 31)

      in Progress Pictures  171 upvotes 3 months ago
      A user shared their 3-month progress using 1mg oral finasteride daily and 5% topical minoxidil twice daily, along with Pura D’Or anti-thinning shampoo and a scalp massager. They noticed initial worsening but later saw hair follicle recovery.

      community Almost 3 months on topical min/fin

      in Progress Pictures  117 upvotes 3 months ago
      A user shared their 3-month progress using topical minoxidil and finasteride for hair loss, expressing hope for continued improvement. Others advised patience, suggesting adding micro-needling and waiting at least a year for significant results.

      community Regrowth on 6 months Dutasteride + Update

      in Is this regrowth?  2 upvotes 3 months ago
      User reports regrowth at temples and improved hairline density after 6 months of using 0.5 mg Dutasteride daily, topical minoxidil twice daily, and vitamins. Considering adding copper peptide but concerned about overdoing it; experiencing increased shedding on the crown.

      community Improvement or Delusional? 21M

      in Is this regrowth?  4 upvotes 3 months ago
      A user is using topical finasteride, keto shampoo, microneedling, and tretinoin for hair loss and is considering adding pyrilutamide. They notice some improvement at the temples and seek advice on whether to focus on cosmetic results despite daily shedding.

      community 3 Month Results with Nuclear Stack - 42M

      in Progress Pictures  114 upvotes 3 months ago
      A user shared 3-month hair regrowth results using a combination of oral Dutasteride, daily Minoxidil, RU58841, micro-needling, Keto shampoo, scalp massages, and supplements. Positive progress was noted, and encouragement to continue was given.

      community Questions about a year of hairloss

      in Treatment  1 upvotes 3 months ago
      A 38-year-old man experiencing rapid hair loss plans to try minoxidil and a derma roller, and may consider finasteride if there's no improvement in six months. He seeks advice on genetic hair loss, baseline baldness, dandruff shampoo, and alternative treatments like tea tree oil and rosemary oil.

      community Pyrilutamide ,the molecule’s true nature

      in Research  302 upvotes 3 months ago
      Pyrilutamide is a selective AR antagonist with a high binding affinity, making it effective in competing with DHT for androgen receptors. The 1% concentration is more effective than the 0.5%, but the latter may suffice for mild hair loss; the drug is considered a good option for those avoiding 5AR blockers due to side effects.

      community Finasteride + Cialis together long term?

      in Treatment  3 upvotes 3 months ago
      The user has been on 1mg finasteride for a year, experiencing low libido and moderate erectile issues. They are considering using Cialis daily with finasteride long term to address these side effects.

      community Combining spironolactone with koshine?

      in Chat 3 months ago
      Combining spironolactone with koshine might enhance the effect of blocking androgen receptors for hair loss treatment. The user suggests adding crushed spironolactone pills to koshine.