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Glossary5α-reductase inhibitors (5ARIs)

block enzyme converting testosterone to hair-loss-causing DHT

5α-reductase inhibitors, also known as 5-ARIs, are medications that block the enzyme 5α-reductase. This enzyme converts testosterone into dihydrotestosterone (DHT), a hormone that can contribute to conditions like male pattern baldness and benign prostatic hyperplasia (BPH). By inhibiting this enzyme, 5-ARIs can help reduce hair loss and shrink an enlarged prostate.

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community 5ARI (dutasteride) Associated with Adverse Metabolic Effects

23 upvotes 6 years ago

Dutasteride is associated with increased blood glucose, HbA1c, LDL cholesterol, and liver enzyme activity, potentially leading to diabetes, NAFLD, and liver metabolism changes. The conversation highlights concerns about these adverse effects and calls for more studies, including on finasteride.

community The best stack that doesn't include a 5ARI

in Treatment 10 upvotes 1 year ago

The conversation is about finding effective hair loss treatments without using finasteride or dutasteride. Suggested treatments include topical minoxidil, oral minoxidil, microneedling, PRP, and RU58841.

community Topical Dutasteride - Non-Hormonal, Side Effect Free 5ARI

in Finasteride/Dutasteride 26 upvotes 3 months ago

The conversation discusses the effectiveness and skepticism around topical dutasteride for hair loss, with mentions of combining it with other treatments like minoxidil and oral medications. Some users doubt its efficacy due to lack of independent studies and potential conflicts of interest.

community Topical Dutasteride - Non-Hormonal, Side Effect Free 5ARI?

in Treatments 372 upvotes 3 months ago

Topical dutasteride is suggested as a low side-effect treatment for hair loss, with a proposed dose of 0.025% 1ml/day. It is considered better than finasteride due to its even inhibition of DHT isoforms and lower systemic absorption.

community 21m, curious about what's going on with my hair

6 upvotes 9 years ago

A 21-year-old male with a thyroid condition noticed his hair thinning uniformly without a receding hairline. He is considering using a 5ARI to prevent further baldness if he starts TRT.

community Allopregnanolone deficiency by 5-ari inhibition (fin/dut users)

in Finasteride/Dutasteride 11 upvotes 11 months ago

The conversation is about managing allopregnanolone deficiency caused by 5-alpha-reductase inhibitors like finasteride or dutasteride. Specific treatments discussed for hair loss include Minoxidil, finasteride, and RU58841.

community This is lagunaboy and I have fully recovered from PFS

in Finasteride/Dutasteride 5 upvotes 2 years ago

The user recovered from Post-Finasteride Syndrome (PFS) using a specific hormone protocol after trying finasteride and dutasteride. They now help others with PFS by reviewing blood work and offering personalized advice.

community What tretinoin product to use in the mix w/ Minoxidil?

in Product 8 upvotes 3 years ago

User uses dermaroller and minox for hair loss without success, considers adding Stemoxydine and mixing tretinoin with minox. Another user suggests a DHT inhibitor for sustainability.

community Once daily topical Min, weekly 1.5 mm dermarolling

in Progress Pictures 35 upvotes 8 months ago

The user has been using 5% minoxidil once daily and microneedling with a 1.5 mm dermaroller weekly for three months, considering increasing minoxidil usage but avoiding finasteride due to libido concerns. Another person suggests considering other treatments like RU58841, alfatradiol, topical finasteride, clascoterone, or saw palmetto since not using a DHT blocker could be less effective.

community Will minoxidil not work if there’s too much DHT present in the scalp?

in Minoxidil 5 upvotes 8 months ago

The user has been using topical finasteride and minoxidil for five months with little progress and is considering oral dutasteride to lower DHT levels, questioning if minoxidil is more effective with reduced DHT. They also use microneedling and tretinoin in their treatment routine.

community Well here I am 3-4 years later.

in Update 56 upvotes 9 months ago

The conversation is about someone who has been taking finasteride for hair loss without success, considering switching to dutasteride or giving up treatment. Suggestions include trying dutasteride, microneedling, infrared therapy, multivitamins, and high-concentration topical solutions combining finasteride and dutasteride.

community Meta analysis: Topical or mesotherapy dutasteride is more effective than topical finasteride in the treatment of AGA in men

in Research/Science 19 upvotes 2 years ago

Topical Dutasteride is more effective than topical Finasteride for treating AGA in men, with fewer side effects. Mesotherapy with Dutasteride, administered every 3 months, shows promising results for hair regrowth and maintenance without daily routines or significant side effects.

community 2024 guide for male pattern baldness: 10 take home messages from Dr. Moreno-Arrones

in Research/Science 243 upvotes 1 month ago

Effective treatments for male pattern baldness include finasteride, dutasteride, and oral minoxidil. Non-effective approaches include oils, shampoos, serums, laser therapies, massages, vitamins, and microneedling.

community Found a Pharmacy that will mix me 0.1 % Alfatradiol (Pantostin)

in Treatment 6 upvotes 2 months ago

The user is currently using 0.025% Pantostin but plans to switch to 0.1% Alfatradiol. They will also use high-dose Kx826, high-dose Minoxidil, and aggressive microneedling for hair regrowth.

community Comparing the effect of T suppression and DHT suppression

in Transgender 52 upvotes 4 months ago

Trans women discuss using finasteride and dutasteride for hair loss and whether to continue after testosterone suppression. One user reduced dutasteride dosage after achieving undetectable testosterone levels.

community Head and Shoulders 2-in-1 shampoo and conditioner use resulting in hair growth by reducing scalp inflammation and DHT?

in Product 4 upvotes 4 months ago

User experienced new hair growth after using Head and Shoulders 2-in-1 shampoo/conditioner, attributing it to pyrithione zinc reducing scalp inflammation and DHT. They seek others' experiences with anti-dandruff products.

community PP405 - hair stem cell stimulation

in Research/Science 51 upvotes 8 months ago

PP405, a topical LDH inhibitor, has shown to stimulate hair follicle stem cell proliferation in humans with moderate hair loss. They are advancing to more detailed trials this year.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

in Research/Science 65 upvotes 1 year ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community Ru, Stemoxydine or Alfatradiol? What has your experience been with any of these 3?

in Treatment 3 upvotes 1 year ago

The user is seeking advice on which treatment to add to their current regimen for male pattern baldness. They have previously tried Dutasteride, Nizoral, and oral Minoxidil, but experienced continued hair loss. They are specifically asking for experiences with RU58841, Stemoxydine, or Alfatradiol.

community Almost 3 weeks on Pyrilutamide-Update

in Update 12 upvotes 2 years ago

The user has been using Actifolic Pyrilutamide 0.5% once daily for almost three weeks without noticing any side effects or progress. Other users suggest that significant results typically take 3-6 months to appear.

community Actifolic RU58841 with octopirox?

in Treatment 1 upvotes 2 years ago

The conversation discusses using RU58841 with octopirox or essential oils for hair loss treatment. The user is seeking advice on which variation to try.

community My dermatologist didn't give me finasteride and instead gave me latanoprost and some cream

in Treatment 7 upvotes 3 years ago

User asked dermatologist for finasteride, received latanoprost and diprogenta cream instead. Others suggest latanoprost is expensive and not better than minoxidil, recommend trying another doctor for finasteride.

community Sulforaphane Topical to Degrade DHT - For People Who Want to Try the Theory that Explains Everything

in Treatment 38 upvotes 3 years ago

A user suggests making a potent sulforaphane topical to degrade DHT and promote hair growth. Another user notes that sulforaphane's low molecular weight might also lower systemic DHT.

community Winlevi coming out in 2019

12 upvotes 6 years ago

The conversation discusses the potential release of Winlevi in 2019 by Cassiopeia for hair loss treatment. It suggests a regimen combining minoxidil, Winlevi, Nizoral, and possibly dermarolling, with a comment mentioning Breezula as an alternative to finasteride without side effects.

community Topical Dutasteride and Mesotherapy Dutasteride: It Works

in Finasteride/Dutasteride 11 upvotes 1 year ago

Topical dutasteride with microneedling and mesotherapy dutasteride injections are effective treatments for androgenetic alopecia in both men and women. These methods offer promising alternatives to oral therapies with potentially fewer systemic side effects.

community KX-826: Long-Term Safety Results are out!

in Research/Science 158 upvotes 1 month ago

KX-826 initially improves hair growth but declines after 24 weeks, with mild itching as a side effect. Combining it with minoxidil and finasteride may improve results, but long-term effectiveness is uncertain.

community No regrowth after oral min, topical fin, min, and tret: Aggressive diffuse/hairline recession in 2 years

in Is this regrowth? 116 upvotes 2 months ago

A user experienced no hair regrowth after using oral minoxidil, topical finasteride, minoxidil, and tretinoin, and reported side effects from oral finasteride. They are considering switching to dutasteride or using hair fibers for better results.

community Getting Ed from 1mg of fin not sure what to do

in Finasteride 190 upvotes 3 months ago

The user experienced erectile dysfunction from 1mg finasteride and sought advice on whether to continue, reduce dosage, or switch treatments. Suggestions included switching to topical finasteride, adding minoxidil, or trying dutasteride.

community 9 Month Journey: Massive Second Minoxidil Shed?

in Minoxidil 43 upvotes 3 months ago

A 33-year-old man shared his 9-month journey using minoxidil for hair loss, experiencing significant shedding after initial success. He is considering adding finasteride but is hesitant due to trying to conceive.

community 20M NW6 diffuse —> NW1 Fin/Dut

in Progress Pictures 72 upvotes 4 months ago

A user shared progress pictures showing improvement from NW6 diffuse to NW1 after 5 months of finasteride and 2 months of dutasteride. Another user asked if these treatments affected beard or body hair thickness.