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Glossary5α-reductase

enzyme converting testosterone into potent dihydrotestosterone (DHT)

5α-reductase is an enzyme that converts testosterone into dihydrotestosterone (DHT), a more potent androgen hormone. This enzyme plays a significant role in various biological processes, including the development of male characteristics and the regulation of hair growth. Inhibitors of 5α-reductase, such as finasteride, are commonly used to treat conditions like male pattern baldness and benign prostatic hyperplasia.

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community Finasteride affects both 5a reductase and 5b reductase

6 upvotes 5 years ago

Finasteride not only inactivates the 5a reductase enzyme but also affects the 5b reductase enzyme in a dose-dependent manner, which can impact sexual behavior and brain activity. The user experienced significant hair regrowth and side effects on 1mg of finasteride, which diminished after reducing the dose to 0.5mg, leading to no side effects and further hair improvement.

community From the research study: "Dihydrotestosterone and the concept of 5a-reductase inhibition in human benign prostatic hyperplasia" - G. Bartsch, R.S. Rittmaster, H. Klocker (2002) in the "World Journal of Urology".

in Research/Science 23 upvotes 2 years ago

Dutasteride is a stronger 5AR inhibitor than finasteride and can significantly lower DHT levels. Reduced doses of dutasteride may lower side effects.

community A repository of links to current scientific research and findings into the nature of and relating to side-effects for Finasteride/Dutasteride/5a-reductase inhibitors.

in Finasteride 17 upvotes 5 years ago

Finasteride and dutasteride, used for hair loss, can cause sexual dysfunction, depression, and suicidal thoughts, with some effects persisting after stopping. The post stresses the importance of being aware of these risks.

community Massive study on finasteride side effects released

in Finasteride/Dutasteride 83 upvotes 2 years ago

The release of a study on 5a-reductase inhibitors (finasteride and dutasteride) which showed an increased risk of depression, dementia, decreased libido, and reduced semen load as potential side effects; discussion around other forms of hair loss treatments such as topical minoxidil, RU58841, or opting to accept baldness; and advice to consider professional help for deeper issues related to hair loss.

community Mechanism of action of alfatradiol (17 alpha estradiol)

in Research/Science 6 upvotes 6 months ago

The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

community Approximation of Scalp DHT Suppression Between 0.05 mg to 2.5 mg

in Research/Science 63 upvotes 10 months ago

The conversation discusses the effectiveness of various doses of Dutasteride in reducing scalp DHT and its impact on hair count. Users shared personal experiences with hair loss treatments, including Dutasteride, Finasteride, and Minoxidil, with one reporting significant hair loss reduction using a combination of oral Dutasteride and topical Minoxidil and Finasteride.

community Hair follicles do die - my „hair“ is the proof of that statement.

in Female 8 upvotes 1 year ago

The user discusses their experience with hair loss despite taking estrogen and cyproterone, and estimates needing around 3000 grafts for a feminine hairline. They are considering getting the procedure done in Turkey due to high European costs.

community What happens to the excess testosterone after using dut?

in Finasteride/Dutasteride 23 upvotes 3 weeks ago

Using dutasteride or finasteride can increase free testosterone, which may convert to estradiol, potentially causing side effects like increased estrogen levels. Individual responses vary, and some users report changes in cholesterol, hair texture, and side effects like gyno or increased sex drive.

community 2024 guide for male pattern baldness: 10 take home messages from Dr. Moreno-Arrones

in Research/Science 245 upvotes 2 months ago

Effective treatments for male pattern baldness include finasteride, dutasteride, and oral minoxidil. Non-effective approaches include oils, shampoos, serums, laser therapies, massages, vitamins, and microneedling.

community Started taking 2.5mg Dut about a month ago

in Technology 17 upvotes 5 months ago

A user started taking 2.5mg Dutasteride for hair loss, along with oral Minoxidil, and is concerned about liver impact. Other users warn about the high dosage and potential health risks.

community Possible explanation of why Dutasteride seems to be worse for some people’s hair.

in Treatment 47 upvotes 1 year ago

The conclusion of the conversation is that some individuals may experience a condition called reactionary hypergonadism when taking dutasteride for hair loss. This condition can lead to an increase in testosterone levels, which may worsen hair loss instead of improving it.

community 3 months with Dutasteride 0.5 mg twice a week and topical minoxidil

in Progress Pictures 15 upvotes 1 year ago

User tried Dutasteride 0.5 mg twice a week and topical minoxidil for 3 months for hair loss. They are happy with the results.

community I just ordered 5 grams of melatonin to make a topical solution

in Research/Science 6 upvotes 2 years ago

The conversation discusses creating a topical hair loss treatment by dissolving melatonin in ethanol and possibly mixing it with castor oil, questioning the stability of the solution. An alternative of using glycerin is also considered.

community Meta analysis: Topical or mesotherapy dutasteride is more effective than topical finasteride in the treatment of AGA in men

in Research/Science 19 upvotes 2 years ago

Topical Dutasteride is more effective than topical Finasteride for treating AGA in men, with fewer side effects. Mesotherapy with Dutasteride, administered every 3 months, shows promising results for hair regrowth and maintenance without daily routines or significant side effects.

community Testosterone in Reference Range Doesn't Cause Hair Loss

in Research/Science 51 upvotes 10 months ago

Testosterone within the normal range does not significantly contribute to male pattern baldness (MPB); DHT is the main factor that can be controlled. Genetics play a crucial role in hair loss, and treatments like finasteride and dutasteride, which block DHT, can help despite potentially raising testosterone levels.

community Trying to understand finasteride side effects and post finasteride syndrome

in Finasteride/Dutasteride 73 upvotes 4 years ago

The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

community Increased adipose tissue (being overweight) in males may increase likelyhood of finasterde side effects

in Research/Science 30 upvotes 3 months ago

Being overweight may increase finasteride side effects due to higher aromatase activity converting testosterone to estradiol. Maintaining a healthy weight could reduce these side effects.

community Fin/Dut and Metabolism Speeds…

in Finasteride/Dutasteride 8 upvotes 3 months ago

A user speculates that a fast metabolism might affect the effectiveness of dutasteride for hair loss. Another user argues that drug response is unrelated to metabolism speed.

community I am horny as hell due to fin.

in Finasteride/Dutasteride 225 upvotes 11 months ago

Some individuals taking finasteride for hair loss report increased libido and frequent masturbation, with no immediate hair regrowth but darker hair appearance. A dermatologist explains that finasteride may raise testosterone levels temporarily, which could lead to increased sex drive in some people.

community If half life of fin is 6-8 hours in the blood but 5-6 days in tissue (scalp) why don't people apply topical every 3-4 days to minimize systemic?

in Treatment 28 upvotes 1 year ago

The discussion revolves around the frequency of applying topical finasteride for hair loss treatment. The main question is whether applying it every 4-5 days could still be effective, given that its half-life in the scalp tissue is 5-6 days.

community More great news about SCUBE3... this could be it!

in Research/Science 30 upvotes 1 year ago

SCUBE3 is a potential hair loss treatment that people are hopeful about. It may provide a solution without the side effects of finasteride.

community where does the renewed spironolactone hype come from?

in Research/Science 9 upvotes 2 years ago

Topical spironolactone is gaining attention as an alternative hair loss treatment, but it's not as effective as other options like finasteride. Oral spironolactone can cause side effects in men, and there are better topical alternatives like RU, Pyril, and CB.

community starting out Nizoral shampoo, do I buy more bottles after I finish or switch back to traditional shampoo?

in Ketoconazole 62 upvotes 2 years ago

Using Nizoral shampoo intermittently and reassessing scalp condition after each bottle, potentially adding in other tools to target seb derm, and alternating between Pura D'Or and Nizoral for a healthy and clean scalp.

community How effective is spironolactone?

in Transgender 6 upvotes 2 years ago

A 21-year-old MTF individual is experiencing rapid hair thinning and is currently on estradiol valerate. They are inquiring about the effectiveness of spironolactone for hair loss, despite being aware of its serious side effects.

community Progressive insomnia (treatment-resistant) due to Finasteride

in Finasteride/Dutasteride 7 upvotes 2 years ago

A medical student experienced hair loss slowing with Finasteride but developed severe, treatment-resistant insomnia. They tried various medications with little effect, suspecting Post-Finasteride Syndrome, and others suggested the insomnia might be linked to Finasteride's impact on neurosteroids.

community My Testosterone results before and after Finasteride

in Update 146 upvotes 3 years ago

Finasteride significantly increased testosterone levels for the user, with no major side effects except watery semen, which was resolved with zinc supplements. The user's hairline stopped receding and slightly improved.

community Has anyone tried the Strut Finasteride Topical Gel?

in Finasteride/Dutasteride 9 upvotes 3 years ago

The conversation is about a 20-year-old male considering a topical gel combining finasteride, minoxidil, and tretinoin for hair loss, looking to replace his daily minoxidil with this new treatment. He has seen good regrowth with minoxidil but is nervous about starting finasteride.

community After almost 4 months on fin, it looks like I might be unlucky enough to develop early sings of gyno...

in Finasteride/Dutasteride 6 upvotes 4 years ago

After nearly four months on finasteride, a user noticed improved hair quality but developed nipple puffiness, suggesting early signs of gynecomastia. They considered switching to other treatments like CB-03-01 or RU58841 and contemplated consulting an endocrinologist about aromatase inhibitors.

community Research Backed Dutasteride Simulator (Serum/Scalp DHT included for all doses)

in Finasteride/Dutasteride 97 upvotes 1 month ago

A dutasteride simulator predicts that daily 0.5 mg dosing results in higher DHT suppression compared to less frequent dosing. Twice-weekly dutasteride may be as effective as finasteride 5 mg, providing a balance between efficacy and ease of use.

community Study shows further evidence that finasteride and dutasteride take 12-18 months or more to show significant results. Do NOT give up early

in Finasteride/Dutasteride 247 upvotes 1 year ago

The conversation discusses the effectiveness of finasteride and dutasteride in treating hair loss, emphasizing that significant results often take 12-18 months or more. Dutasteride is generally considered superior, with similar or fewer side effects than finasteride, but patience is required for noticeable improvement.