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Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

The conversation discusses the lack of significant advancements in hair loss treatments since the introduction of finasteride 22 years ago, with many expressing frustration over the failure of new projects and skepticism about future developments. Some users mention hair transplants and other potential alternatives like Alfatradiol and Fluridil, but acknowledge finasteride's dominance in the market due to its effectiveness and affordability.

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

A user has been using minoxidil for hair loss and has seen positive results, but is seeking additional treatments to enhance its effects. One suggestion given is to use finasteride alongside minoxidil.

Finasteride significantly increased testosterone levels for the user, with no major side effects except watery semen, which was resolved with zinc supplements. The user's hairline stopped receding and slightly improved.

The post and conversation are about the role of the enzyme 3alpha-hydroxysteroid reductase in hair loss and the potential of compounds like procyanidin B2 and sulforaphane to boost its activity for hair regrowth. Further research is needed to develop effective treatments based on this theory.

Hair regrowth treatments for cis-males include Minoxidil, Finasteride, and RU58841. Estrogen and testosterone blockers can help restore hair loss but may not suit everyone.

The post discusses using RU58841 and 5% minoxidil for hair loss treatment, with RU applied to the temples and crown, and minoxidil used twice daily. Users debate the effectiveness of RU58841 compared to minoxidil alone.

A 27-year-old user shared their 5-month progress using 1mg finasteride daily and 5% minoxidil twice a day for hair loss, reporting improved hair growth despite initial shedding and experiencing only minor side effects like watery semen. They also use Nizoral shampoo, take a multivitamin, and plan to start microneedling if progress slows.

The conversation discusses hair regrowth using Finasteride, Alpecin shampoo, vitamins, RCP serums, and Redensyl, with noticeable improvement in the fifth month. The user experienced some shedding initially but found stability without using Minoxidil, as advised by their dermatologist.

A user shared their positive experience with hair regrowth using a topical treatment containing 0.3% finasteride, 7% minoxidil, ketoconazole, and biotin. They noticed results after about three months, experienced some initial shedding, and had minor headaches as a side effect.

The user experienced significant hair regrowth and reduced shedding after increasing their dosage of minoxidil to 5mg daily and finasteride to 5mg three times a week. They reported noticeable improvements within five months and encouraged others to consider this treatment.

A 55-year-old user shared progress pictures after 5 months of using dutasteride 6 times a week and minoxidil 2.5 mg daily, reporting hair regrowth and some side effects like mild erectile dysfunction and foot swelling. The user attributes recent hair loss to creatine and notes improvement after adjusting the treatment regimen.

The user reported positive hair regrowth after 5 months using Minoxidil, red light therapy, and lifestyle changes, including dietary improvements and stress reduction. They chose natural supplements like saw palmetto and beta-sitosterol over pharmaceutical DHT inhibitors like finasteride.

A user reported impressive hair regrowth after 5 months using finasteride 1mg daily, topical minoxidil 5% twice a day, and microneedling. They initially experienced shedding but now have minimal hair loss and no sexual side effects.

A 20-year-old male has been using a topical mix of finasteride, minoxidil, and tretinoin for five months without seeing significant hairline improvement. He is considering adding oral dutasteride or a hair transplant for better results.

A user shared their 5-month hair transplant progress, having undergone a procedure with 4100 grafts at MedBlue in Istanbul for $3,600. They started taking oral minoxidil and finasteride daily after the transplant and use topical minoxidil with microneedling every two weeks, reporting positive results and no unwanted hair growth.

The user experienced significant hair regrowth after switching from finasteride to dutasteride and from topical to oral minoxidil, despite some patchiness along the hairline. The user reduced the oral minoxidil dose due to low blood pressure concerns.

The user is happy with hair regrowth after 5 months using topical minoxidil twice daily, oral finasteride once daily, derma stamping weekly, and Watermans shampoo. They noticed darker hair and stopped using creatine, suspecting it worsened hair loss.

The user switched from finasteride to dutasteride, taking 0.5 mg oral dutasteride and 2.5 mg oral minoxidil daily, and reported significant hair regrowth with no side effects. The user experienced a shedding phase lasting a bit over a month after switching to dutasteride.

A 21-year-old has been using a 0.5 mm dermaroller weekly with 5% Minoxidil for five months and Finasteride for three months to address hair loss. The conversation includes questions about the frequency of dermarolling.

A 35-year-old male uses topical minoxidil, spironolactone, and microneedling for hair loss, with spironolactone prescribed based on a DNA test indicating poor response to finasteride and dutasteride. Despite concerns about the test's validity and spironolactone's side effects, he reports stable or improved hair condition and no low testosterone symptoms.

The user is using finasteride (1 mg daily), topical minoxidil, and microneedling with a derma stamp for hair loss. They reported shedding stopped and new hair growth appeared after a few months, with no side effects.

The user experienced significant hair regrowth using 5% Minoxidil, 1mg Finasteride, and Nizoral, with minimal side effects like occasional dandruff. Shedding occurred initially but led to positive results over time.

The user shared a 5-month update on using finasteride, minoxidil, and ketoconazole shampoo for diffuse thinning, along with supplements like B-Vitamins, D-Vitamins, Iron, and Beta carotene. They noted improvement in hair condition and encouraged others to check previous posts for more information.

Significant hair regrowth was achieved using oral finasteride and topical minoxidil over five months, with noticeable improvements in hairline and temple areas. The user experienced minimal side effects, mainly increased eyebrow and eyelash growth, and attributes additional physical improvements to weight loss and exercise.

The user has been using finasteride and minoxidil for 5 years to prevent hair loss and is considering adding dutasteride for regrowth or opting for a hair transplant. Suggestions include trying dutasteride, oral minoxidil, microneedling, and possibly a hair transplant for better results.

The user shared their 5-month hair progress using oral finasteride and minoxidil, reporting positive results with minimal side effects. They use a chewable 2-in-1 product from Hims for convenience.

The user reported significant hair regrowth using a topical treatment of 0.3% finasteride and 6% minoxidil, with noticeable progress in five months. The treatment is applied once daily, and the user experienced some initial shedding but no side effects.