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GlossaryCYP27B1 (1-alpha-hydroxylase)

enzyme converting inactive vitamin D to its active form

CYP27B1, also known as 25-hydroxyvitamin D3 1-alpha-hydroxylase, is an enzyme that plays a crucial role in the metabolism of vitamin D. It converts inactive vitamin D into its active form, calcitriol, which is essential for calcium absorption and bone health. This enzyme is important for maintaining proper levels of calcium and phosphate in the blood, which are vital for normal bone formation and maintenance.

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community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

in Research/Science 92 upvotes 2 years ago

The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 97 upvotes 4 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community The theory that explains everything - First Evidence of Hair regrow attributed to upregulating 3aHSD

in Treatment 173 upvotes 3 years ago

Hair regrowth treatment involving 3aHSD enzyme shows 6% improvement in 18 weeks. Sulforaphane, L-Menthol, and Dexpanthenol are potential ingredients for new hair loss solution.

community Update about Hair Follicle Glucose Metabolism: New Clinical Data Collection with Ex-President Of American Board Of Hair Restoration Surgery.

in Research/Science 41 upvotes 5 months ago

David Barreto shared that a London-based research group is conducting a 12-month trial for a new nutraceutical treatment for pattern hair loss, designed with Dr. Carlos Puig. The trial aims to provide robust data, with results expected in 1-2 years, potentially representing a significant advancement since finasteride’s introduction in 1997.

community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001) Pt 2

in Research/Science 479 upvotes 4 months ago

Sugary beverages increase the risk of pattern hair loss in men by 57%. Treatments discussed include Minoxidil, finasteride, and RU58841.

community What has helped you regrow your temples?

in Chat 21 upvotes 1 year ago

User seeks advice for regrowing temples, currently using Fin, oral Min, and dermarolling. Suggestions include improving scalp environment and considering RU58841 or dutasteride.

community ghk-cu is potent 5-ar inhibitor?

in Product 9 upvotes 10 months ago

GHK-Cu is a potent inhibitor of the type 1 5-alpha reductase enzyme in hair follicles, which may reduce hair loss without the side effects associated with type 2 5-alpha reductase inhibitors. The user previously experienced side effects with 5-alpha reductase inhibitors and is considering GHK-Cu as an alternative.

community Approximately 1 month on oral dut+ oral min

in Progress Pictures 103 upvotes 6 months ago

A user shared progress pictures after one month on oral dutasteride and minoxidil, noting some improvement despite initial shedding. They previously used finasteride for a year without noticeable change and emphasized the importance of photo comparisons.

community 5ar Type I in the frontal hair follicles - Dutasteride

in Finasteride/Dutasteride 21 upvotes 7 months ago

The conversation discusses that dutasteride may be more effective than finasteride for frontal hair loss due to higher 5ar Type 1 enzyme activity in that area. Some users question the validity of this information, while others confirm it with additional sources.

community Be careful when switching from Finasteride to Dutasteride because for more efficacy.

in Finasteride/Dutasteride 13 upvotes 2 months ago

Switching from finasteride to dutasteride may be more effective for hair regrowth due to dutasteride's stronger enzyme inhibition, but combining both drugs could enhance results. Some users report better outcomes with dutasteride, while others recommend a gradual transition to prevent potential hair loss.

community I have a hard time believing that creatine overpowers fin/dut

in Finasteride/Dutasteride 109 upvotes 1 year ago

The conversation is about whether creatine causes hair loss in individuals who are taking finasteride or dutasteride for hair loss. Some users report experiencing hair loss when taking creatine, while others do not. There is no consensus on the issue.

community Finasteride gains continue well into year 5

in Chat 118 upvotes 7 months ago

Finasteride can continue to improve hair loss for up to 10 years, with the best results seen when started early. Combining treatments like minoxidil, dermarolling, or RU58841 may enhance effectiveness.

community The Golden Hair Regrowth/Loss Prevention Regimen With Results and Explanation

in Treatment 223 upvotes 2 years ago

Hair loss prevention and regrowth regimen includes finasteride, oral minoxidil, stemoxydine, hair growth serum, derma rolling, and ketocanazole shampoo. Users discuss efficacy, safety, and personal experiences with treatments.

community 5ar alpha reductase stimulation is different depending on whether it’s type 1 or 2

in Hair Systems 16 upvotes 1 year ago

The conversation discusses how different factors can stimulate type 1 and type 2 isoforms of 5-alpha reductase, which are enzymes linked to hair loss. Specific treatments mentioned include oral Dutasteride and topical Finasteride.

community 17-alpha-estradiol/Alfatradiol how does it Work for Hair loss?

in Treatment 2 upvotes 5 days ago

17-alpha-estradiol may work for hair loss by inhibiting 5-alpha reductase, similar to finasteride. It might lower testosterone in the scalp, reducing DHT conversion.

community Kintors 1% Pyrilutamide comes in October/November

in Treatment 21 upvotes 4 months ago

Kintor's 1% Pyrilutamide will be released in October/November. The user cannot tolerate finasteride.

community 1 year Post HT 2200 Grafts + fin 8 Months Then switched to dut

in Progress Pictures 519 upvotes 2 years ago

A user who experienced positive results from using finasteride and dutasteride to treat their hair loss, with 2000 grafts being transplanted in the temples area for further improvement. They also discussed cost and other treatments such as minoxidil.

community 1 year fin 1mg and minox. can see some density reclaimed

in Update 562 upvotes 3 years ago

User shared 1-year progress using finasteride 1mg and minoxidil, regaining hair density. Others praised the improvement and asked about side effects and additional treatments.

community Dutasteride takes 1-3 months to work in the scalp. Not weeks. Be careful.

in Finasteride/Dutasteride 41 upvotes 4 months ago

Dutasteride takes 1-3 months to affect scalp DHT levels, not just a week. The prostate absorbs Dutasteride faster than the scalp due to different vascular networks and enzyme densities.

community 1 year 2months finasteride/question about dutasteride.

in Finasteride/Dutasteride 121 upvotes 1 year ago

Hair loss treatments, including finasteride and dutasteride. It is suggested to try minoxidil with microneedling as an additional treatment for regrowth, and the user reports that it took around 6 months of taking 1mg of finasteride every day before seeing results.

community Glycine supplementaion is said to strongly upregulate 5-alpha Reductase (5-ar) Activity

in Research/Science 15 upvotes 4 years ago

Glycine supplementation may increase 5-alpha reductase activity, potentially affecting hair loss. Users discuss its impact on hair fall and its role in the body.

community Day 1 vs Day 168 (today) of defeating the norwood reaper

in Progress Pictures 1505 upvotes 3 months ago

The user achieved significant hair regrowth using topical 5% minoxidil and oral 1mg finasteride daily, especially around the temples. They experienced minimal side effects, with initial difficulty maintaining erections that resolved after a few weeks.

community Head and Shoulders 2-in-1 shampoo and conditioner use resulting in hair growth by reducing scalp inflammation and DHT?

in Product 4 upvotes 5 months ago

User experienced new hair growth after using Head and Shoulders 2-in-1 shampoo/conditioner, attributing it to pyrithione zinc reducing scalp inflammation and DHT. They seek others' experiences with anti-dandruff products.

community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 2 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.

community 12 mo 1 ml daily Min/Dermaroller 1mm-1.5mm update + AGA progression theory and specific order of treatment

in Microneedling 15 upvotes 3 years ago

A user shared their year-long hair loss treatment using minoxidil, microneedling, and scalp massages, reporting moderate hair growth and stabilization. They suggest starting early with less harmful methods and consider adding finasteride or dutasteride if needed.

community Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid????

1 upvotes 6 years ago

The post discusses using a topical tincture containing zinc, azelaic acid, and other ingredients to inhibit 5 alpha-reductase activity for treating hair loss. The user plans to try this natural alternative before using finasteride or RU58841.

community Incredible results after just 1 month on dutasteride and minoxidil!

in Progress Pictures 108 upvotes 2 months ago

A user reported significant hair improvement after one month of using dutasteride and oral minoxidil. Others expressed skepticism, attributing perceived changes to lighting and styling, and debated the effectiveness and risks of these treatments.

community Minoxidil Beard Growth Stack + Protocol (Only 1.5 years commitment)

in Minoxidil 7 upvotes 7 months ago

A user shared a beard growth protocol involving hydration toner, azelaic acid, tretinoin, moisturizer, 5% topical minoxidil, and SPF 30+ sunscreen. The regimen spans a year to a year and a half, with specific application schedules for different phases.

community 2 years of fin, 1.5 years of minoxidil, calling it quits. Thank you.

in Shaved/buzzed 567 upvotes 1 year ago

This user has been struggling with hair loss for the past two years and attempted to treat it using finasteride and minoxidil. Despite their efforts, they have not seen any improvement in their condition, so they have decided to shave or buzz their head instead. Others gave advice on other treatments that could be tried if desired.

community personal progress (~8-9months) with fin(1.25mg)/min/needling/niz

in Progress Pictures 571 upvotes 2 years ago

A user's personal hair loss progress with treatments, including finasteride (1.25mg), minoxidil, needling, and Nizoral; and advice from other users on how to perform the needling correctly.