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Glossary17α-estradiol

stereoisomer of estradiol studied for treating hair loss

17α-estradiol, also known as 17-alpha-estradiol, is a stereoisomer of the hormone estradiol. Unlike its more common counterpart, 17β-estradiol, 17α-estradiol has weaker estrogenic activity but has been studied for its potential benefits in treating conditions like androgenic alopecia (hair loss) due to its ability to modulate androgen metabolism.

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community If you could get for Christmas your own personalised topical anti hair loss serum that has the best the current science can offer, what would it contain and at what concentration?

in Treatment 1 upvotes 1 day ago

A personalized topical anti-hair loss serum could include high-dose setipiprant, high-dose CB 03-01, low-dose finasteride, minoxidil, latanoprost, and tretinoin. These ingredients are suggested for their potential effectiveness in promoting hair growth.

community NW 2 -> NW 1,5 15Mg oral Minoxidil (💀) + Dut 0,5mg 12 Months

in Progress Pictures 77 upvotes 1 year ago

The user, Albertgejmr, is happy with their progress in treating hair loss using 15mg oral minoxidil and 0.5mg Dutasteride. Some users express concern about the high dosage and potential side effects.

community Help with female pattern baldness

in Female 10 upvotes 1 year ago

A user discusses their struggle with female pattern baldness, mentioning that Minoxidil helped initially but their hair health declined after stopping a specific diet. They seek advice on managing oily, brittle hair and mention using an egg yolk and olive oil mixture as a temporary solution.

community Be careful when switching from Finasteride to Dutasteride because for more efficacy.

in Finasteride/Dutasteride 13 upvotes 2 months ago

Switching from finasteride to dutasteride may be more effective for hair regrowth due to dutasteride's stronger enzyme inhibition, but combining both drugs could enhance results. Some users report better outcomes with dutasteride, while others recommend a gradual transition to prevent potential hair loss.

community Would Fluridil and Alfatradiol work effectively in conjunction with each other?

in Treatment 10 upvotes 4 years ago

Whether using both Fluridil and Alfatradiol together could be more effective than either one alone as a hair loss treatment, given their different mechanisms of action.

community losing hair as a female 17-18 years old feels terrible

in Female 15 upvotes 4 years ago

A female, aged 17-18, is experiencing significant hair loss, feeling hopeless despite trying various treatments like leave-in conditioners, omega-3s, supplements, sulfate-free shampoo, and biotin. She is distressed as her hair continues to thin, affecting her body image and self-esteem.

community I think we all hop on estrogen. It's the only angle

in Satire 83 upvotes 4 months ago

The conversation humorously discusses hair loss treatments, including Minoxidil, finasteride, RU58841, and topical 17 alpha estradiol, with some users joking about transitioning to female to avoid baldness. The overall tone is satirical, emphasizing self-acceptance and the lengths people might consider for hair restoration.

community PYRILUTAMIDE KX-826 experience

in Research/Science 98 upvotes 2 years ago

A user's experience with the hair loss treatment Pyrilutamide KX-826, which has resulted in some side effects and shedding. The conversation also includes advice for baseline pictures and trying treatments for at least 6 months.

community What has helped you regrow your temples?

in Chat 21 upvotes 1 year ago

User seeks advice for regrowing temples, currently using Fin, oral Min, and dermarolling. Suggestions include improving scalp environment and considering RU58841 or dutasteride.

community Anyone knows a legitimate online source/distributer of 17α-estradiol (Alfatradiol) powder?

in Treatment 1 upvotes 2 months ago

The conversation is about finding a legitimate online source for 17α-estradiol (Alfatradiol) powder to make a 0.1% solution for hair loss treatment. A user suggests Anagenica as a source.

community 17-alpha-estradiol/Alfatradiol how does it Work for Hair loss?

in Treatment 2 upvotes 5 days ago

17-alpha-estradiol may work for hair loss by inhibiting 5-alpha reductase, similar to finasteride. It might lower testosterone in the scalp, reducing DHT conversion.

community Mechanism of action of alfatradiol (17 alpha estradiol)

in Research/Science 6 upvotes 6 months ago

The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

community The first three months on minoxidil 2%

in Is this regrowth? 1 upvotes 2 months ago

The user noticed hair thinning and has been using a treatment with minoxidil 2%, hydrocortisone butyrate, and 17 alpha estradiol for three months, seeing some regrowth. The user had dermatitis, now cured, which worsened the hair loss.

community Dim: high estradiol levels what to do

in Chat 8 upvotes 5 months ago

A user is experiencing facial bloating from low-dose topical finasteride due to high estradiol levels and is seeking advice on using DIM to manage this issue, including dosage and brand recommendations.

community Going to a cosmetic derm soon. What should I ask for?

in Female 3 upvotes 1 year ago

Female, 28, losing hair since 17, using 200mg Spiro. Tried Minoxidil and ketoconazole with limited success, considering oral minox and seeking alternative treatments from cosmetic dermatologist.

community On a super stack, but still miniaturizationg going strong???

in Update 8 upvotes 2 years ago

User "Number_Worried00" is using a treatment stack for hair loss, including Minoxidil, Finasteride, Dutasteride, Estradiol, Cetirizine, and Pyrilutamide. Another user suggests that if the cause is vitamin deficiency or inflammation, the stack may not be effective.

community Aromatise inhibitor for finasteride-estrogen side effects?

in Finasteride/Dutasteride 6 upvotes 2 years ago

A user experienced mild side effects from 0.5mg finasteride daily, including increased estradiol and minor gynecomastia. They are considering taking a low dose of exemestane to reduce estrogen levels.

community 8 week - sharing Finasteride blood test update

in Progress Pictures 6 upvotes 1 year ago

A 32-year-old male started taking 0.5mg of finasteride daily for hair thinning and, after 8 weeks, experienced a 70% reduction in DHT and an increase in estradiol; he is currently in the shedding phase of treatment and questioning if the dosage is correct based on his DHT levels. He began with a lower dose due to already low normal testosterone and DHT levels.

community 26M Baseline blood work done before Finasteride

in Finasteride/Dutasteride 8 upvotes 3 years ago

A person considering finasteride for hair loss checked their hormone levels before starting treatment. They are concerned about the potential increase in estradiol and its effects, as well as the impact on their sex hormone-binding globulin (SHBG) and free testosterone levels.

community Bloodwork Results. DHT and Testosterone Levels

in Update 6 upvotes 6 months ago

The user shared their bloodwork results showing DHT at 17 ng/dl and testosterone at 287 ng/dl, with a slight Vitamin D deficiency. They are seeking opinions on these levels and have an upcoming dermatologist appointment.

community Hair loss treatment rabbit hole [OC]

in Satire 317 upvotes 2 years ago

Hair loss treatments, ranging from topical minoxidil and finasteride to taking hormones such as estradiol or nandrolone, as well as a controversial suggestion of an orchiectomy. A hair system is also mentioned as an alternative solution.

community Estradiol (E2), Testosterone and DHT levels after 1 month on Dutasteride

in Research/Science 13 upvotes 3 weeks ago

Dutasteride and finasteride are used for hair loss, affecting hormone levels like DHT and testosterone. Hormone balance is crucial, as changes can lead to side effects such as increased estradiol and potential hair loss.

community Let this be a warning to all, if you see progress, DONT STOP THE CONSISTENCY

in Update 492 upvotes 1 year ago

A user shared their experience with hair loss treatments Minoxidil and Finasteride. They saw improvement but stopped using them, leading to significant hair loss, and are now considering restarting the treatments.

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

in Research/Science 101 upvotes 2 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.

community Goodbye y'all, it's been a journey but have accepted where I'm at

in Update 219 upvotes 1 year ago

The conclusion of this conversation about hair loss is that the user, y00sh420, tried various treatments including a $700 lllt helmet, topical minoxidil and finasteride, spectraDNC, and micro needling, but did not achieve the desired results. They have decided to stop trying until a cure for male pattern baldness is found. Other users expressed different opinions on hair loss treatments.

community to all people who cannot tolerate anti androgens (loe dose topical fin, pyrilutamide, CB) i am getting desperate, looking for a solution

in Research/Science 13 upvotes 1 year ago

The user tried Minoxidil without success, and Finasteride worked but caused sexual side effects even at a very low dose. They are seeking alternative treatments for hair loss as they cannot tolerate anti-androgens and are also in therapy for mental health.

community Just checked my hormones before starting Fin

in Finasteride/Dutasteride 5 upvotes 1 month ago

A user is considering starting finasteride for hair loss and shares their hormone levels, with others suggesting checking SHBG and discussing potential side effects. Some recommend starting with 0.5 mg finasteride, while others suggest considering dutasteride.

community Do i have to worry about mixing these ingredients with Finasteride?

in Treatment 4 years ago

The user is concerned about mixing Pantostin (with Alfatradiol) and Finasteride in a topical solution, fearing a potential toxic reaction or ineffectiveness. They seek advice on whether this combination is safe.

community Spironolactone, what do you think?

in Finasteride/Dutasteride 4 upvotes 4 months ago

A user is considering Spironolactone for hair loss but is advised against it due to its effects on testosterone. Instead, they are recommended to try finasteride at 18 and consider dutasteride if needed.

community I’m already DOING EVERYTHING!!!

in Female 27 upvotes 3 years ago

A 26 year old female dealing with hair loss who is considering treatments such as Spiro, minoxidil and finasteride. Other potential solutions mentioned are PRP treatment, a wig, and bio-identical estrogen combined with bica.