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research 376 Tsc2 disruption in mesenchymal progenitors regulates hair follicles and TGF beta signaling

April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study in mice suggests that defects in hair follicles with mesenchymal TSC2 disruption may result from an impaired TGFβ1 response, indicating a potential novel treatment approach for tuberous sclerosis complex.

research Dose-Dependent Histopathological and Structural Impact of Chemical Hair-Straighteners on Scalp Epithelium and Hair-Fibres Using Albino Wistar Rats

September 2025 in “Sahel Journal of Life Sciences FUDMA”

This study reported that albino Wistar rats exposed to chemical hair straighteners showed significant hair fiber damage and scalp skin deterioration, which worsened with repeated and prolonged application, highlighting the cytotoxic potential of these products and potential systemic risks.

research Dandelion-Derived Carbon Dots with pH-Responsive Charge and Dual ROS Regulation for Anti-Infection and Accelerated Wound Repair

June 2026 in “ACS Applied Materials & Interfaces”

In this study, carbon dots derived from dandelion herb demonstrated significant antibacterial and biofilm-disrupting capabilities, promoting wound healing in a mouse model infected with S. aureus, while also showing excellent biocompatibility and the ability to modulate reactive oxygen species.

research 259 Immunohistochemical insight into the association between the collapse of immune privilege in the sweat gland and syringotropic immune cell infiltrates in collagen diseases

September 2017 in “Journal of Investigative Dermatology”

This study suggests that sweat glands may have an immune privilege similar to hair follicles, and disruptions in this could contribute to autoimmune skin diseases.

research THE ROLE OF LEGAL ADDICTIVE SUBSTANCES IN SKIN PATHOLOGIES: A LITERATURE REVIEW

December 2025 in “International Journal of Innovative Technologies in Social Science”

This study concluded that alcohol and tobacco products harm the skin by disrupting microcirculation, impairing the epidermal barrier, slowing wound healing, and accelerating the aging process.

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community Minoxidil inhibits lysyl hydroxylase which is needed to produce collagen. If I take 2,5...5 mg of minoxidil every day can I cause my skin to age prematurely?

32 upvotes 1 year ago

Oral minoxidil is effective for hair loss and unlikely to significantly affect collagen synthesis, making it a safe option without causing premature skin aging. Users report positive hair regrowth without noticeable skin aging.

community microneedle, any long term users damage?

in Microneedling 35 upvotes 2 years ago

Microneedling is effective for hair growth, especially when combined with finasteride and minoxidil, but concerns exist about potential long-term skin damage. Users report increased collagen and elastin deposition, but the long-term effects on the scalp remain uncertain.

community Rejux-3x - the copper peptide combo that tressless overlooks.

1 upvotes 6 months ago

Rejuv-3X, a topical blend with GHK-Cu, AHK-Cu, and JXL-089, is used for hair loss, offering a targeted option without finasteride's side effects. The user plans to combine it with microneedling for enhanced results.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

76 upvotes 2 years ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Testosterone in Reference Range Doesn't Cause Hair Loss

52 upvotes 2 years ago

Testosterone within the normal range does not significantly contribute to male pattern baldness (MPB); DHT is the main factor that can be controlled. Genetics play a crucial role in hair loss, and treatments like finasteride and dutasteride, which block DHT, can help despite potentially raising testosterone levels.

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