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GlossaryConfocal Microscopy (CLSM)

uses laser light to create detailed, three-dimensional images

Confocal Microscopy, also known as Confocal Laser Scanning Microscopy (CLSM), is an advanced imaging technique that uses laser light to scan samples and create high-resolution, three-dimensional images. By focusing on a specific plane within the sample and excluding out-of-focus light, it provides clearer and more detailed images than traditional microscopy, making it particularly useful for studying complex structures like hair follicles and skin tissues in both research and medical diagnostics.

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research Confocal Laser Scanning Microscopy as a Tool for the Investigation of Skin Drug Delivery Systems and Diagnosis of Skin Disorders

4 citations, March 2013 in “InTech eBooks”

Confocal Laser Scanning Microscopy (CLSM) is a useful tool for studying how drugs interact with skin and diagnosing skin disorders, despite some limitations.

research Permeant Lipophilicity and Vehicle Composition Influence Accumulation of Dyes in Hair Follicles of Human Skin

44 citations, April 2003 in “European journal of pharmaceutical sciences”

Lipophilic dyes accumulate more in hair follicles when delivered with surfactant-propylene glycol solutions.

Investigation of the Cutaneous Penetration Behavior of Dexamethasone Loaded to Nano-Sized Lipid Particles by EPR Spectroscopy, and Confocal Raman and Laser Scanning Microscopy

research Investigation of the Cutaneous Penetration Behavior of Dexamethasone Loaded to Nano-Sized Lipid Particles by EPR Spectroscopy, and Confocal Raman and Laser Scanning Microscopy

21 citations, December 2016 in “European journal of pharmaceutics and biopharmaceutics”

Nano-sized lipid particles increase dexamethasone's skin penetration and create a reservoir in the skin layers.

Mechanistic Analysis of Human Skin Distribution and Follicular Targeting of Adapalene-Loaded Biodegradable Nanospheres With Insight Into Hydrogel Matrix Influence, In Vitro Skin Irritation, and In Vivo Tolerability

research Mechanistic Analysis of Human Skin Distribution and Follicular Targeting of Adapalene-Loaded Biodegradable Nanospheres With Insight Into Hydrogel Matrix Influence, In Vitro Skin Irritation, and In Vivo Tolerability

17 citations, June 2017 in “Journal of pharmaceutical sciences”

Researchers developed a nanomedicine for acne treatment that delivers medication with less irritation and is non-irritating for oily skin.

research Development and Skin Penetration Pathway Evaluation Using Confocal Laser Scanning Microscopy of Microemulsions for Dermal Delivery Enhancement of Finasteride

1 citations, December 2022 in “Pharmaceutics”

Finasteride-loaded microemulsions can effectively enhance skin delivery for treating hair loss.

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