July 2026 in “bioRxiv (Cold Spring Harbor Laboratory)” This study observed distinct sex differences in hair growth cycles and regeneration in C3H/He mice, noting that females regenerated hair faster after adhesive material application, whereas males were more reliant on macrophage activity for this process.
44 citations
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January 2019 in “Journal of Translational Medicine” This study found that macrophages are crucial for skin regeneration during tissue expansion, as their depletion in rats led to inhibited skin growth and reduced secretion of key growth factors.
175 citations
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December 2014 in “PLoS Biology” This study found that macrophages near hair follicles contribute to the activation of skin epithelial stem cells in mice, suggesting a novel role for macrophages in regulating hair growth.
163 citations
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April 2019 in “Nature Communications” This study found that mechanical skin stretching can stimulate hair stem cell proliferation and hair regeneration by activating a complex pathway involving WNT, BMP-2, and M2 macrophages.
69 citations
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September 2006 in “Human Reproduction” This study found that CD45RO+ cells, a subtype of T lymphocytes, were notably reduced in the ovarian follicles of women with PCOS, which may contribute to the condition's pathogenesis.