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learn Clascoterone

a novel topical treatment that inhibits DHT on androgen receptors

Is clascoterone suitable for both men and women? Clascoterone is not approved for hair loss in either sex — the approved product is a 1% acne cream. The scalp version has completed phase III trials in men with sponsor-reported positive results; in women the only data is a company-reported phase II significant in one subgroup, so use is off-label and investigational for both.
What is clascoterone and how does it work against hair loss? Clascoterone is a topical treatment that blocks DHT to prevent hair loss.
How long does it take for clascoterone to show results on hair growth? Clascoterone is not approved for hair loss; it is investigational. In the trials reported so far, application was twice daily and increases in terminal hair count were reported at around 6 months, with more sustained change reported between 6 and 12 months.
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Research

5 / 91 results

Expanding The Therapeutic Versatility Of Clascoterone

research Expanding the therapeutic versatility of clacosterone

October 2023 in “Journal of the American Academy of Dermatology”

This source reports that clascoterone cream has been approved in the U.S. for treating acne vulgaris in patients aged 12 and older, suggesting it works by competing with dihydrotestosterone at androgen receptors to mitigate acne's effects.

research Androgens and acne: perspectives on clascoterone, the first topical androgen receptor antagonist

9 citations , April 2021 in “Expert opinion on pharmacotherapy”

This review highlights that clascoterone, a newly FDA-approved topical androgen antagonist, effectively reduces both non-inflammatory and inflammatory acne lesions with no systemic effects, making it a promising new option for acne treatment in both male and female patients.

research Clascoterone: First Approval

27 citations , October 2020 in “Drugs”

This article reviews the development milestones of clascoterone up to its first approval for treating acne vulgaris, reporting no new clinical results for androgenetic alopecia.

research Use of topical clascoterone for the treatment of hidradenitis suppurativa

10 citations , April 2023 in “JAAD Case Reports”

This article discusses the challenges in treating hidradenitis suppurativa, highlighting that adalimumab is currently the only FDA-approved treatment, and reports no clinical results.

research Clascoterone as a novel treatment for androgenetic alopecia

5 citations , May 2020 in “Clinical and Experimental Dermatology”

This correspondence discusses clascoterone as a potential new treatment for androgenetic alopecia but reports no clinical results.

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Community Join

5 / 259 results

community Why is clascosterone (cb0301) so expensive ?

3 upvotes 1 month ago

Clascosterone (CB0301) is expensive due to concentrated form and lack of market competition. Users discuss sourcing from Indian and Chinese pharmacies for cheaper alternatives, but express concerns about product quality.

community Whatever happened to Clascoterone? (breezula for hair) (sold as Winlevi for acne available since 2021)

4 upvotes 1 week ago

Clascoterone (Breezula) is anticipated for release in the coming years but is considered too weak for aggressive androgenetic alopecia (AGA). Current treatments like minoxidil, finasteride, and dutasteride are preferred, with some users obtaining clascoterone from the gray market.

community Clascoterone full results 2026

7 upvotes 2 weeks ago

Clascoterone results are anticipated to be released in fall 2026, possibly at the EADV conference. Users express skepticism and humor about the release date.

community Why is everyone still arguing about PP405 when clascoterone is already heading toward regulatory submission?

46 upvotes 1 month ago

Clascoterone is nearing regulatory submission as a potential new treatment for androgenetic alopecia, with positive Phase III results, while discussions continue about other treatments like PP405, minoxidil, and finasteride. Some users express excitement for clascoterone and Breezula, despite concerns about the effectiveness and practicality of topical treatments.

community Clascoterone might be the Finasteride for female pattern hair loss.

9 upvotes 1 month ago

Clascoterone, a topical anti-androgen, shows promise for treating female pattern hair loss without systemic side effects, offering a potential alternative to minoxidil. It could also benefit men who experience side effects from finasteride.

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