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Casein Kinase 1 Inhibition in Keratinocytes Enhances the Migration of Melanocyte Precursors in the Hair Follicle via KitL/c-Kit Signaling Pathway

research Casein Kinase 1 Inhibition in Keratinocytes Enhances the Migration of Melanocyte Precursors in the Hair Follicle via KitL/c-Kit Signaling Pathway

April 2023 in “Journal of Investigative Dermatology”

Blocking casein kinase 1 in skin cells can help melanocyte precursors move better, potentially helping with conditions like vitiligo or gray hair.

research Inhibition of Wnt/β-Catenin Pathway Promotes Regenerative Repair of Cutaneous and Cartilage Injury

41 citations, August 2015 in “The FASEB Journal”

Blocking the Wnt/β‐catenin pathway can speed up wound healing, reduce scarring, and improve cartilage repair.

research Hair Growth Promoting Effects of 15-Hydroxyprostaglandin Dehydrogenase Inhibitor in Human Follicle Dermal Papilla Cells

July 2024 in “International Journal of Molecular Sciences”

The inhibitor DPP can promote hair growth.

research Wnt Is Back in Drugmakers' Sights, but Is It Druggable?

10 citations, November 2018 in “Nature Biotechnology”

Drugmakers are optimistic about targeting the Wnt pathway for new treatments despite past challenges.

research PKC Downregulation Upon Rapamycin Treatment Attenuates Mitochondrial Disease

26 citations, December 2020 in “Nature metabolism”

Rapamycin treatment helps with mitochondrial disease by reducing PKC levels.

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community Pyrilutamide update number 2 - 2 week use

in Update 174 upvotes 2 years ago

An update on the use of Pyrilutamide, a new drug for hair loss, which has resulted in no shedding or testicle ache; other users have questioned the science behind this and shared their own experiences with Finasteride, Minoxidil, and microneedling.