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This narrative review evaluates evidence that regional hypothermia can reduce oral, hair, eye, and nail complications from chemotherapy, but highlights the need for more research to address study limitations.

The researchers reported that both cryotherapy and betamethasone lotion yielded similar improvement rates for alopecia areata patches, without complete recovery observed in any patient.

Among patients treated at Thomas Jefferson University, this study found that adding cryotherapy to intralesional triamcinolone acetonide (IL TAC) was more effective at reducing keloid size compared to IL TAC alone, although both treatments similarly eased pruritus and pain.

This study found that both fractional CO2 laser and cryotherapy were effective and safe treatments for alopecia areata, with the CO2 laser showing somewhat better results.

This study found that freezing nitrogen ethanol composite (FNEC) caused less cryoablative damage to surrounding normal tissue than liquid nitrogen in a mouse model of human bone xenograft transplantation.