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Glossary Chronic Stress

continuous state of stress experienced over an extended period

Chronic stress, also known as long-term or persistent stress, refers to a continuous state of stress experienced over an extended period. This type of stress can result from ongoing pressures such as work demands, financial difficulties, or relationship problems. It can lead to various health issues, including cardiovascular diseases, weakened immune function, and mental health disorders like anxiety and depression. Chronic stress can also contribute to conditions like alopecia, where prolonged stress disrupts the normal hair growth cycle, leading to hair loss.

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Research

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research Divergent neuroactive steroid responses to stress and ethanol in rat and mouse strains: relevance for human studies

34 citations , April 2014 in “Psychopharmacology”

This review discusses the pharmacological properties and physiological regulation of neuroactive steroids, focusing on their varied responses to stress and ethanol in rats, mice, and humans, but it reports no new findings.

research Stress-induced Interaction of Skin Immune Cells, Hormones, and Neurotransmitters

88 citations , May 2020 in “Clinical therapeutics”

This review discusses the role of stress mediators in skin diseases and reports no new clinical results; the authors suggest further research in skin psychoneuroimmunology.

research A novel MBTPS2 variant associated with BRESHECK syndrome impairs sterol‐regulated transcription and the endoplasmic reticulum stress response

5 citations , October 2021 in “American Journal of Medical Genetics Part A”

This case report identifies a novel maternally inherited MBTPS2 variant associated with an expanded phenotypic spectrum of BRESHECK syndrome, including cytopenias, bone marrow fibrosis, and chronic diarrhea.

research Determining Cortisol in Animal Hair as a Marker of Chronic Stress

December 2025 in “Biology Bulletin Reviews”

This research review highlights how hair cortisol concentration can reflect the activation of the stress-response system in farm, domestic, and wild animals, noting it correlates with factors like species, sex, age, and environmental conditions, which may influence stress and adaptation.

research Hyposecretion of the adrenal androgen dehydroepiandrosterone sulfate (DHEA-S) in the majority of the alopecia areata patients: Is it a primitive and pathogenic perturbation of hypothalamic-pituitary-adrenal axis?

3 citations , January 2011 in “International journal of trichology”

Low DHEA-S levels might be linked to alopecia areata and could be a potential treatment target.

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community A stress hormone has been found to signal through skin cells to repress the activation of hair-follicle stem cells in mice

30 upvotes 5 years ago

Stress can lead to hair loss by affecting hair-follicle stem cells, and this loss is harder to recover from if one has male pattern baldness (MPB). Treatments like finasteride and minoxidil are used to address hair loss, but stress-related hair loss differs from androgenic alopecia.

community I'm becoming non-responder to minoxidil. What's going on?

7 upvotes 1 year ago

The user experienced reduced effectiveness of minoxidil after consistent use, despite using dutasteride to maintain hair. They are considering alternatives like microneedling and exploring options like hair transplants due to dissatisfaction with current hair density.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community How is it possible for someone to be a non responder to ORAL minoxidil?

in Minoxidil 66 upvotes 2 years ago

Some individuals do not respond to oral minoxidil for hair loss, despite it generally working by improving blood flow to hair follicles. Factors like metabolism, drug interactions, and individual variations in the drug's activation may influence its effectiveness.

community 9 years of hair loss process and 27 months of treatment. What's going on?

40 upvotes 1 year ago

The user experienced hair loss diagnosed as chronic Telogen Effluvium and male pattern baldness, treated with finasteride and minoxidil, later switching to dutasteride due to side effects but with limited success. The user plans to return to finasteride due to side effects from dutasteride, while others suggest maintaining consistent treatment and considering additional options like oral minoxidil and lifestyle changes.

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learn Neem Oil

Oil from the neem tree, used in traditional remedies

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Hair Systems
Hair Response Inc.Arlington Heights, IL · US

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