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Permanent Alopecia as a Manifestation of Chronic Graft-Versus-Host Disease of the Scalp: Clinical, Dermoscopic, and Histopathological Observations

research Permanent alopecia as a manifestation of chronic graft-versus-host disease of the scalp: clinical, dermoscopic and histopathological observations

2 citations , June 2018 in “Clinical and Experimental Dermatology”

Permanent hair loss after a stem cell transplant can be a sign of chronic immune system attack on the scalp.

research A RARE FORM OF SUPPURATING AND CICATRIZING DISEASE OF THE SCALP

11 citations , December 1921 in “Archives of dermatology and syphilology”

This article reviews historical cases and descriptions of perifolliculitis capitis abscedens et suffodiens, highlighting its characteristics and treatment, but reports no new clinical findings.

research Plucked hair follicles from patients with chronic discoid lupus erythematosus show a disease-specific molecular signature

17 citations , July 2019 in “Lupus Science & Medicine”

In this study, gene expression analysis of plucked hair follicles from scalp lesions was sufficient to differentiate chronic discoid lupus erythematosus from psoriasis and healthy controls, suggesting a non-invasive diagnostic potential.

research Erosive pustular dermatosis of the scalp following topical ingenol mebutate for actinic keratoses

9 citations , July 2017 in “Dermatologic Therapy”

Two elderly men developed scalp inflammation after using a gel for skin lesions, which healed with treatment except for some permanent hair loss.

Acute Hair Loss Three Years After Bone Marrow Transplant

research Acute Hair Loss 3 Years after Bone Marrow Transplant

1 citations , January 2019 in “Skin appendage disorders”

This case report highlights that new onset non-scarring alopecia after allogeneic stem cell transplantation may indicate chronic graft-versus-host disease.

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Community Join

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community Hair Loss “Cure” for Inflammation: Topical Roflumilast

in Research/Science 32 upvotes 8 months ago

Topical roflumilast is effective for reducing inflammation in various scalp conditions like seborrheic dermatitis, psoriasis, and eczema, but not proven to stop scarring alopecia. Alternatives like apremilast and Vtama are also discussed for their anti-inflammatory benefits.

community I think I’ve finally found the reason for my hair loss

in Chat 98 upvotes 1 year ago

The user experienced hair loss since 2019 and tried finasteride, dutasteride, RU58841, and ketoconazole shampoo without success. A scalp biopsy showed scarring and inflammation from folliculitis, indicating chronic inflammation was affecting treatment effectiveness.

community DHT Harms Scalp Microbiome: DHT Itch is REAL

413 upvotes 1 year ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community DHT Itch and Oily Scalp Explained (and how to fix it)

90 upvotes 3 months ago

Malassezia overgrowth can worsen oily scalp and inflammation, contributing to hair loss. Treatments include antifungal shampoos, C6/C8 MCT oil, low-dose isotretinoin, finasteride, and dutasteride.

community Dutasteride takes 1-3 months to work in the scalp. Not weeks. Be careful.

in Finasteride/Dutasteride 41 upvotes 2 years ago

Dutasteride takes 1-3 months to affect scalp DHT levels, not just a week. The prostate absorbs Dutasteride faster than the scalp due to different vascular networks and enzyme densities.

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Learn

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learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn sh-Polypeptide-7

learn Beta Polypeptide

learn Fluocinolone

What type of hair loss is Fluocinolone recommended for, and how does it help inflamed scalps? Fluocinolone is a prescription topical corticosteroid used for inflammatory scalp conditions such as seborrheic dermatitis, scalp psoriasis and scarring alopecias. It calms inflammation rather than growing hair, it is not a treatment for pattern hair loss, and its labelling warns against prolonged use.

learn Cetirizine

What makes cetirizine a unique anti-inflammatory option for your scalp? Laboratory work reports that cetirizine lowers PGD2 and other inflammatory mediators, which is why researchers have proposed it for the scalp. There is no approved topical product and the clinical evidence is one small unblinded pilot study in pattern hair loss, so scalp use is off-label and experimental.

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Clinics

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Experts

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24
Trichologist
Kirsten J. Scalp
Greenville, SC, United States

Kirsten J. Scalp