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research A novel MBTPS2 variant associated with BRESHECK syndrome impairs sterol‐regulated transcription and the endoplasmic reticulum stress response

5 citations , October 2021 in “American Journal of Medical Genetics Part A”

This case report identifies a novel maternally inherited MBTPS2 variant associated with an expanded phenotypic spectrum of BRESHECK syndrome, including cytopenias, bone marrow fibrosis, and chronic diarrhea.

research The ‘bald’ phenotype (androgenetic alopecia) is caused by the high glycaemic, high cholesterol and low mineral ‘western diet’

7 citations , June 2021 in “Trends in Food Science and Technology”

This commentary reviews potential dietary and mineral influences on androgenetic alopecia and suggests considering a diet low in cholesterol and glycaemic index with improved glucose control and magnesium fortification, without new clinical results.

research Surface Lipids as Multifunctional Mediators of Skin Responses to Environmental Stimuli

105 citations , January 2010 in “Mediators of Inflammation”

This article reviews the role of skin surface lipid in mediating environmental stressors and discusses potential therapeutic interventions, reporting no new experimental findings.

research Role of cholesterol sulfate in epidermal structure and function: Lessons from X-linked ichthyosis

87 citations , March 2014 in “Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids”

This paper discusses X-linked ichthyosis and its genetic causes, focusing on biochemical pathways and their role in epidermal differentiation and barrier function, but it presents no new clinical findings.

research Evidence of a Causal Relationship Between Body Mass Index and Immune-Mediated and Inflammatory Skin Diseases and Biomarkers: A Mendelian Randomization Study

2 citations , November 2024 in “Clinical Cosmetic and Investigational Dermatology”

This Mendelian randomization study suggests a causal link between higher BMI and increased risk of psoriasis, atopic dermatitis, and hidradenitis suppurativa, potentially due to elevated biomarkers such as triglycerides and C-reactive protein.

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community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

63 upvotes 2 years ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community Is it even possible to lose your hairline in one night?

4 upvotes 6 years ago

Hair loss can occur rapidly due to various factors like genetics, mistreatment, or medication. Treatments mentioned include minoxidil.

community How to BECOME a RESPONDER to Fin/Dut if you are not responding

308 upvotes 3 years ago

The conclusion of this conversation is that the user "DuckSeasonCamelSeasn" found that consuming grapefruit juice prior to taking finasteride or dutasteride helped them become a responder to the medications and regain hair growth. However, there are warnings about potential risks and interactions with other medications, so caution should be exercised.

community A warning to those using or thinking about using Dutasteride – Follow-up

18 upvotes 5 years ago

The post and conversation are about the long-term side effects of using Dutasteride and Finasteride for hair loss, including issues like raised liver enzymes, high cholesterol, and loss of libido. The user advises regular blood work and careful monitoring for those using these treatments.

community A warning to those thinking about using Dutasteride

in Finasteride/Dutasteride 99 upvotes 6 years ago

The potential risks of long-term use of Dutasteride and how it may be linked to elevated liver enzymes, cholesterol levels, and decreased testosterone. Alternative treatments such as Finasteride and RU58841 were also discussed.

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