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      research RAGE and Its Ligands in Melanoma

      1 citations , April 2015 in “InTech eBooks”
      The document discussed the role of the receptor for advanced glycation end products (RAGE) and its ligands in melanoma progression, identifying RAGE as a potential therapeutic target due to its involvement in cell proliferation, migration, and inflammation. RAGE overexpression in melanoma cells led to decreased proliferation but increased migration and invasion, with significant variations in expression levels across samples. S100 proteins, particularly S100B, S100A2, S100A4, and S100A6, were linked to cancer progression, interacting with the tumor suppressor p53 and affecting its function. S100B served as a prognostic marker for stage IV melanoma. Advanced Glycation End-products (AGEs) and High Mobility Group Box 1 protein (HMGB1) were also implicated in promoting metastasis and angiogenesis through RAGE signaling. Despite the potential of targeting RAGE/ligand interactions with inhibitors like soluble RAGE (sRAGE) and anti-RAGE antibodies, the efficacy in melanoma remained uncertain due to variable RAGE levels, necessitating further studies.
      Diagnostic Approach to Low-Renin Hypertension

      research Diagnostic Approach to Low-Renin Hypertension

      29 citations , May 2018 in “Clinical Endocrinology”
      Recent genetic insights show that low-renin hypertension includes a range from essential hypertension to secondary or familial forms, affecting diagnosis and treatment.

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      community Carnitine Tartrate + Potassium chloride + Niacin

       6 upvotes 11 years ago
      The post discusses using Carnitine Tartrate, Potassium Chloride, and Niacin to reduce hair shedding, with the user experiencing significant improvement. The user also suggests considering a ketogenic/paleo diet for those with insulin resistance-related hair loss.

      community Better then Minoxidil( at least for me and my family)

      in Treatment  45 upvotes 1 year ago
      Capronium Chloride and Trichoxidil are suggested as better alternatives to Minoxidil for hair growth without heart side effects. The Japanese Dermatological Association recommends topical Minoxidil over Capronium Chloride.

      community How do you prevent infection with derma needling / derma stamping?

      in Microneedling  1 upvotes 7 months ago
      The conversation discusses preventing infection from derma stamping for hair loss treatment, with suggestions to reduce needle depth and consider alternatives like tretinoin. The user experienced irritation possibly from zinc chloride and stopped using the shampoo and derma stamping.

      community Topical finasteride carrier/vehicle

      in Finasteride  135 upvotes 1 year ago
      The user is considering making a homemade topical finasteride solution using an ethanol-based carrier. They are inquiring if a solution containing partially denatured ethyl alcohol and benzalkonium chloride is suitable.

      community Is there a big difference between name brand and cheaper hair fibres?

      in Product  1 upvotes 2 years ago
      A user is comparing the effectiveness and ingredients of name-brand hair fibers (Nanogen) versus cheaper generic options found on eBay. They are concerned about the presence of sodium chloride in the generic product and seek opinions on whether there is a significant difference in quality.