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This study found that chitosan nanofibrillar scaffolds accelerated skin wound healing in mice by enhancing cell adhesion, proliferation, and regeneration of epidermis and dermis compared to other forms.

In this study, a dual-layer electrospun nanofibrous mat incorporating chitosan nanoparticles, growth factors, and hair follicle bulge stem cells significantly enhanced wound healing in a rat model.

This study found that Forskolin-loaded carboxymethyl chitosan-silk nanofiber hydrogels promoted wound healing by accelerating wound closure, enhancing neovascularization, and supporting hair follicle regeneration, while also being non-toxic and encouraging the proliferation of certain cell types.

In this study, poly (ɛ-caprolactone)–chitosan–poly (vinyl alcohol) nanofibrous scaffolds used on canine skin wound models were found to significantly accelerate healing rates of excision and burn wounds, without inducing immunogenic reactions.

This study found that chitosan and surface-deacetylated chitin nanofibrils promoted hair growth in mice and increased fibroblast growth factor-7 production in human follicle dermal papilla cells.