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research Androgen Receptor Actions Modify Skin Structure and Chemical Carcinogen-induced Skin Cancer Susceptibility in Mice

14 citations , January 2015 in “Hormones and Cancer”

This study found that androgen receptor inactivation in male and female mice reduced susceptibility to DMBA-induced skin cancer, but the effect varied by the carcinogenesis model.

research Expression of the human Cathepsin L inhibitor hurpin in mice: skin alterations and increased carcinogenesis

21 citations , August 2007 in “Experimental Dermatology”

This study found that mice genetically modified to overexpress the serine protease inhibitor hurpin showed reduced UV-induced apoptosis but increased susceptibility to skin cancer after chemical carcinogenesis.

research Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis

54 citations , February 2002 in “Carcinogenesis”

This study suggests that activation of polyamine catabolism in K6-SSAT transgenic mice may significantly increase skin tumor development and progression to carcinomas following chemical induction.

research Lgr6+ stem cells and their progeny in mouse epidermis under regimens of exogenous skin carcinogenesis, and their absence in ensuing skin tumors

7 citations , November 2016 in “Oncotarget”

This study found that Lgr6+ stem cells in mice are not major initiators of UV- or chemically induced skin tumors.

research Data from Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity

March 2023

This study found that inhibiting AP-1 transcription factors in mice causes squamous tumors to transform into sebaceous tumors and regulates tumor cell lineage.

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community TCA 35% chemical peel, don't try this shit at home.

11 upvotes 7 months ago

The conversation discusses using a TCA 35% chemical peel on the scalp to potentially improve hair growth by addressing fibrosis and enhancing the effectiveness of topical treatments. The user also mentions trying microneedling and other methods like topical metformin and dutasteride for hair regrowth.

community Can the ingredients in a sebum-regulating shampoo induce hair diameter reduction?

2 upvotes 1 year ago

A user experienced hair thinning and scalp issues after using a sebum-regulating shampoo and perm treatments. They are advised to consider potential allergies, try a simple shampoo, and research treatments like finasteride for possible male pattern baldness.

community Minoxidil actually reduces wrinkles

in Research/Science 209 upvotes 1 year ago

Minoxidil may improve or worsen skin quality, with topical forms causing dryness and wrinkles, possibly due to alcohol content, while oral forms have fewer side effects. Some users consider using tretinoin to mitigate negative effects.

community The case of a 78 year old man who accidentally regrew his hair (published in the British Medical Journal)

in Chat 213 upvotes 10 months ago

A 78-year-old man regrew hair after suffering burns, suggesting that injury-induced healing processes might trigger hair growth. Microneedling and other treatments like minoxidil and finasteride are discussed as potential methods to stimulate similar regrowth.

community Extremely potent catalyst for Minoxidil

6 upvotes 6 years ago

Using Megatek with minoxidil significantly increases hair growth, especially vellus hairs, but is less effective alone. Biotin and ketoconazole shampoo are also used to support hair health.

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SMP Specialist
Noelle Skin
Nice, France

Noelle Skin