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GlossaryImmune Checkpoint Inhibitors (immune checkpoint blockade)

block proteins that prevent immune cells from attacking cancer

Immune Checkpoint Inhibitors (ICIs) are a type of cancer treatment that work by blocking proteins used by cancer cells to evade the immune system. By inhibiting these checkpoints, such as PD-1, PD-L1, and CTLA-4, ICIs enable the immune system to better recognize and attack cancer cells.

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research A Comparative Analysis of Immune Privilege in Pregnancy and Cancer in the Context of Checkpoint Blockade Immunotherapy

16 citations , March 2018 in “Seminars in Oncology”

The document concludes that pregnancy and cancer share immune evasion tactics, but more research is needed before using checkpoint blockade immunotherapy in pregnant cancer patients to avoid harm to the placenta.

research An In Situ Chemotherapy Drug Combined with Immune Checkpoint Inhibitor for Chemoimmunotherapy

1 citations , December 2023 in “Nanomaterials”

Combining specific nanoparticles with immune therapy significantly improves cancer treatment.

research Melanoma: Genetic Abnormalities, Tumor Progression, Clonal Evolution, And Tumor-Initiating Cells

37 citations , November 2017 in “Medical Sciences”

Melanoma's complexity requires personalized treatments due to key genetic mutations and tumor-initiating cells.

research The Dual Nature of Cellular Senescence: From Aging Signature to Regenerative Catalyst

January 2025 in “Research”

Cellular senescence can both hinder and promote hair growth, suggesting new ways to treat hair loss.

research Alopecia Areata: Animal Models Illuminate Autoimmune Pathogenesis and Novel Immunotherapeutic Strategies

82 citations , March 2016 in “Autoimmunity reviews”

Animal models have helped understand hair loss from alopecia areata and find new treatments.

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community 6th Month Checkpoint! There is progress (I think?)

in Progress Pictures 29 upvotes 11 months ago

The conversation discusses a user's six-month progress in treating hereditary hair loss using a regimen that includes minoxidil, finasteride, dutasteride, and other medications. Opinions vary on the effectiveness and logic of the treatment, with some users suggesting additional methods like microneedling.

community Oral min 2.5mg / oral fin 1mg / 3.5 months - 25M progress

in Progress Pictures 168 upvotes 4 months ago

A 25-year-old shared progress on hair growth using oral minoxidil 2.5mg, oral finasteride 1mg, and dermarolling over 3.5 months, noting improvements and encouraging others to persist with treatments. Other users discussed their experiences with similar treatments, including topical minoxidil, ketoconazole shampoo, and tretinoin cream, with varying results and side effects.

community My journey so far, what can you guys tell me?

in Is this regrowth? 7 upvotes 3 weeks ago

The user has been using finasteride since January 2025 and topical minoxidil since July 2024, noticing some regrowth but also thinning on the left side of the hairline. They are considering switching to dutasteride or oral minoxidil for better results.

community PP405 - A True Breakthrough or Another Disappointment?

in Research/Science 35 upvotes 3 months ago

PP405 shows potential for hair growth, with 31% of advanced balding men experiencing over 20% increase in hair density in 8 weeks. However, skepticism persists due to selective data presentation and lack of long-term results, with comparisons to treatments like minoxidil and finasteride.

community Dutasteride Infertility Debunked: Low T causes true infertility.

in Finasteride/Dutasteride 166 upvotes 6 months ago

Dutasteride and finasteride may temporarily affect semen quality but are unlikely to cause permanent infertility. The Kim et al. study is criticized for poor methodology, and many prefer hair retention over potential fertility concerns, using treatments like dutasteride, finasteride, and minoxidil.

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