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This study found that mice deficient in ceramide synthase 4 showed altered sebum composition and progressive hair loss due to obstructed hair canals.

This study found that inactivating CerS4 in mice led to hair follicle stem cell exhaustion and hair loss, indicating its role in regulating hair regeneration through ceramide composition and signaling pathways.

Ceramide Synthase 4 is crucial for healthy skin barrier function.

This study found that inactivating CerS4 in mouse epidermis disrupts lipid homeostasis and is crucial for maintaining, but not forming, the skin barrier.