April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that JAK1 and JAK3 inhibitors effectively reversed alopecia in a mouse model of AA by reducing skin inflammation, while JAK2 inhibition did not promote hair regrowth.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that JAK1 and JAK2 inhibitors increase β-catenin activity in human hair follicle cells, suggesting an additional therapeutic mechanism for treating severe alopecia areata.