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      learn Exosomes

      Microscopic delivery system that sends growth-promoting signals to hair follicles

      learn Ketoconazole

      antifungal with some anti-androgenic benefits, often used as a shampoo

      learn Platelet-Rich Plasma

      growth factors taken from your blood and injected into your scalp to stimulate hair

      learn Follistatin

      glycoprotein that inhibits TGF-β and promotes hair growth by antagonizing activin

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      community DHT Harms Scalp Microbiome: DHT Itch is REAL

      in Research/Science  407 upvotes 3 weeks ago
      Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 8 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.