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Glossary CDK inhibitors

block enzymes that regulate cell cycle progression

CDK inhibitors, or Cyclin-dependent kinase inhibitors, are a class of drugs that block the activity of enzymes known as cyclin-dependent kinases (CDKs). These enzymes play a crucial role in regulating the cell cycle, and their inhibition can halt the proliferation of cancer cells, making CDK inhibitors valuable in cancer treatment.

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Research

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research Alopecia induced by CDK 4/6 Inhibitors and its Impact on the Quality of Life of Patients with advanced Breast cancer

November 2025

This study found that 49% of female breast cancer patients treated with CDK4/6 inhibitors for at least three months developed alopecia, which significantly impacted their quality of life, with greater alopecia severity leading to worse emotional and functional well-being.

research Retrospective cohort study of CDK4/6-inhibitor-induced alopecia in breast cancer patients

9 citations , November 2023 in “Supportive Care in Cancer”

This study found that breast cancer patients treated with CDK4/6 inhibitors plus endocrine therapy experienced more pronounced vertex hair loss and were less responsive to minoxidil treatment compared to those on endocrine monotherapy.

research CDK4/6 plus aromatase inhibitor-induced alopecia in breast cancer patients.

4 citations , May 2019 in “Journal of Clinical Oncology”

This study found that cyclin-dependent kinase 4/6 inhibitors used for metastatic breast cancer caused alopecia resembling androgenetic alopecia, negatively impacting patients' quality of life, but topical minoxidil showed potential for improvement.

research Hormone receptor positive, HER2 negative metastatic breast cancer: Impact of CDK4/6 inhibitors on the current treatment paradigm

4 citations , October 2018 in “Asia-Pacific Journal of Clinical Oncology”

This review discusses the use of CDK4/6 inhibitors with endocrine therapy in treating women with HR+ HER2- advanced breast cancer, but it reports no new clinical findings.

research Impact of CDK4/6 inhibitors on health-related quality of life outcomes in patients with metastatic breast cancer: A systematic review and meta-analysis

1 citations , November 2025 in “Journal of Managed Care & Specialty Pharmacy”

This study concluded that while CDK4/6 inhibitors, used to treat HR+ HER2- metastatic breast cancer, generally did not worsen health-related quality of life, they were associated with increased patient-reported issues like diarrhea and hair loss upset.

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Community Join

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community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

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