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research A locus on distal chromosome 10 (ahl4) affecting age-related hearing loss in A/J mice

62 citations , April 2008 in “Neurobiology of aging”

This study identified a new genetic locus, ahl4, on distal Chromosome 10 that contributes to the early-onset, severe hearing loss in A/J mice compared to B6 mice.

research Hair cell loss – cause or consequence of hearing loss?

April 2026 in “Frontiers in Cell and Developmental Biology”

This literature review suggests that hair cell loss in hearing loss is often secondary to preceding morphological and functional defects in hair cells, indicating that interventions should focus on hearing preservation before significant hair cell loss occurs.

research Auditory Threshold Variability in the SAMP8 Mouse Model of Age-Related Hearing Loss: Functional Loss and Phenotypic Change Precede Outer Hair Cell Loss

13 citations , August 2021 in “Frontiers in Aging Neuroscience”

This study found that in SAMP8 mice, phenotypic changes in outer hair cells or the stria vascularis, possibly due to oxidative deficiencies, may predict variability in age-related hearing loss before outer hair cell loss occurs.

research Rapamycin but not acarbose decreases age-related loss of outer hair cells in the mouse Cochlea

15 citations , September 2018 in “Hearing research”

This study suggests that rapamycin, but not acarbose, can delay age-related loss of cochlear outer hair cells in UM-HET3 mice at doses that increase life span.

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