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GlossaryCD3 complex

group of proteins on T cells aiding immune response signaling

The CD3 complex is a group of proteins found on the surface of T cells, which are a type of white blood cell crucial for the immune system. These proteins work together to help the T cell recognize and respond to foreign invaders, such as viruses or bacteria, by transmitting signals from the cell surface to its interior, initiating an immune response.

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research Multiplex Matrix Network Analysis of Protein Complexes in the Human TCR Signalosome

32 citations, August 2016 in “Science Signaling”

Alopecia areata patients show unique protein activity patterns, suggesting imbalanced signaling pathways.

research Bioinformatics Analysis of Genes Associated with Patchy-Type Alopecia Areata: CD2 May Be a New Therapeutic Target

4 citations, September 2019 in “Biomedical Papers/Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc Czech Republic”

CD2 might be a new treatment target for patchy alopecia areata.

research Hairless-Knockout Piglets Generated Using CRISPR/Cas9 Exhibit Abnormalities in Skin and Thymus

3 citations, January 2019 in “Jikken doubutsu ihou/Jikken doubutsu/Experimental animals/Jikken Dobutsu”

Pigs without the Hairless gene showed skin and thymus changes, useful for studying human hair disorders.

research NF-κB in Biology and Targeted Therapy: New Insights and Translational Implications

1 citations, March 2024 in “Signal transduction and targeted therapy”

NF-κB signaling is crucial in many diseases and can be targeted for new treatments.

research Clinical Application of Nonantibiotic Macrolides for Inflammation-Driven Immune Dysfunction in Inflammatory Skin Diseases

22 citations, January 2012 in “Mediators of inflammation”

Nonantibiotic macrolides show promise for treating various inflammatory skin conditions.

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