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Divergent Proliferation Patterns of Distinct Human Hair Follicle Epithelial Progenitor Niches In Situ and Their Differential Responsiveness to Prostaglandin D2

research Divergent Proliferation Patterns of Distinct Human Hair Follicle Epithelial Progenitor Niches In Situ and Their Differential Responsiveness to Prostaglandin D2

21 citations , November 2017 in “Scientific Reports”

Different human hair follicle stem cells grow at different rates and respond differently to a baldness-related compound.

Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

research Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

106 citations , March 2014 in “BioEssays”

We need more research to better understand human hair follicle stem cells for improved treatments for hair loss and skin cancer.

research Biochemistry of Epidermal Stem Cells

26 citations , July 2012 in “Biochimica et Biophysica Acta (BBA) - General Subjects”

The review found that different stem cell types in the skin are crucial for repair and could help treat skin diseases and cancer.

research Role of Bulge Epidermal Stem Cells and TSLP Signaling in Psoriasis

19 citations , September 2019 in “EMBO molecular medicine”

Blocking TSLP reduces skin inflammation and cell overgrowth in psoriasis.

research The Physiological and Pharmacological Roles of Prostaglandins in Hair Growth

October 2022 in “The Korean Journal of Physiology and Pharmacology”

Targeting the PGD2-DP2 pathway may help treat hair loss.

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community My Theory Of Androgenic Alopecia

in Research/Science 19 upvotes 4 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community PP405 Won’t Work: Follicle Is Miniaturized, Fibrosed, And Missing Key Support Cells

in Research/Science 1 month ago

PP405 is ineffective for miniaturized, fibrosed hair follicles in androgenetic alopecia. AMP303 may activate hair follicle stem cells, but minoxidil and finasteride are still the main treatments.