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GlossaryCXCR4 (CD184)

receptor protein involved in immune cell movement and cancer

CXCR4, also known as C-X-C chemokine receptor type 4 or CD184, is a protein found on the surface of certain cells that plays a crucial role in the immune system. It acts as a receptor for a molecule called CXCL12, which helps guide the movement of cells, including immune cells, to sites where they are needed, such as areas of inflammation or injury. This receptor is also involved in the development and progression of various diseases, including cancer and HIV, making it a significant target for medical research and therapeutic interventions.

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research A Polygenic Mouse Model of Psoriasiform Skin Disease in CD18-Deficient Mice

89 citations, March 1996 in “Proceedings of the National Academy of Sciences”

CD18-deficient mice developed psoriasis-like skin disease, useful for studying inflammatory skin disorders.

research ESGCT and FSGT Collaborative Congress Helsinki, Finland September 17–20, 2015 Abstracts

2 citations, October 2015 in “Human Gene Therapy”

The congress highlighted new gene therapy techniques and cell transplantation methods for treating diseases.

Nuclear Factor (Erythroid-Derived 2)-Like-2 Pathway Modulates Substance P–Induced Human Mast Cell Activation and Degranulation in the Hair Follicle

research Nuclear Factor (Erythroid-Derived 2)-Like-2 Pathway Modulates Substance P–Induced Human Mast Cell Activation and Degranulation in the Hair Follicle

8 citations, May 2018 in “The Journal of Allergy and Clinical Immunology”

Activating the Nrf2 pathway reduces inflammation and cell activation in human hair follicles, suggesting a potential treatment for certain hair loss conditions.

research Mechanisms Regulating Skin Immunity and Inflammation

610 citations, April 2014 in “Nature Reviews Immunology”

The document concludes that understanding how the skin's immune system and inflammation work is complex and requires more research to improve treatments for skin diseases.

research Transplantation Immunology: Solid Organ and Bone Marrow

139 citations, February 2010 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

Transplant success has improved with better immunosuppressive drugs and donor matching.

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