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research Intermolecular NH2-/Carboxyl-Terminal Interactions in Androgen Receptor Dimerization Revealed by Mutations That Cause Androgen Insensitivity

227 citations , January 1998 in “Journal of biological chemistry/The Journal of biological chemistry”

Mutations at Val-889 and Arg-752 disrupt key interactions in the androgen receptor, affecting its function.

research Intermolecular NH2-/Carboxyl-Terminal Interactions in Androgen Receptor Dimerization Revealed by Mutations That Cause Androgen Insensitivity

2 citations , July 2021 in “UNC Libraries”

Mutations at Val-889 and Arg-752 disrupt key interactions in androgen receptor dimerization.

research Down-Regulation of Melanocortin Receptor Signaling Mediated by the Amino Terminus of Agouti Protein in Xenopus Melanophores

43 citations , May 1999 in “Journal of Biological Chemistry”

Agouti protein affects melanocortin receptors through competitive antagonism and receptor down-regulation.

research The Agouti Gene in Obesity: Central and Peripheral Mechanisms, and Therapeutic Implications

May 2001

The agouti gene may help understand and treat obesity.

research Intramembrane Proteolysis of Astrotactins

8 citations , January 2017 in “Journal of Biological Chemistry”

Astrotactin-2 is cleaved in a specific way that helps understand its maturation.

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community Anybody else obsessively searching for pp405 and counting the days?

in Technology 69 upvotes 9 months ago

People are eagerly awaiting the release of PP405, a new hair loss treatment. Some are using minoxidil and finasteride in the meantime, but there are concerns about scams and unverified products.

community PP405 Identity Research

UmbrellaLabsResearch in Research 292 upvotes 7 months ago

PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.

community How to tell if finasteride is working for you

in Finasteride/Dutasteride 27 upvotes 1 year ago

Finasteride's effectiveness can be gauged by reduced hair shedding, but some users report it losing efficacy over time. Other treatments mentioned include Minoxidil, ketoconazole shampoo, and QR678, with mixed results.