![Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)](/images/assets/d743d32f-3115-48ff-9697-2f2d56130701/small/14175.jpg)
6 citations
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September 2015 in “Journal of Medicinal Chemistry” This study synthesized and verified the structures of Setipiprant's major and minor metabolites, confirming their regio- and enantioselectivity from earlier proposals in a clinical study.
23 citations
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June 2014 in “International Journal of Cosmetic Science” This study reported that the treatment of hair with glyoxylic acid straighteners causes major conformational changes within the hair fiber due to interactions between carbonyl and keratin components.
18 citations
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March 2009 in “Skin pharmacology and physiology” This study found that sunlight exposure causes significant structural and chemical damage to hair, including cuticle loss, cortex damage, and discoloration, with water playing a major role in discoloration of brown hair.
May 2026 in “International Journal of Cosmetic Science” This study found that repeated exposure to ozonated water caused oxidative changes in hair proteins, lipids, and pigments, leading to altered hair properties, with minimal effects on shine and color.
August 2015 in “Free Radical Biology and Medicine” This study explores the correlation between sirtuins' expression, histone deacetylation, and redox status in young and old monozygotic twins to understand their role in age-related mechanisms.