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In this case study, a 17-year-old male using topical minoxidil 5% for beard growth developed peripheral edema, which resolved after discontinuing the drug, highlighting a rare but significant systemic side effect of minoxidil's use.

Minoxidil affects rat fluid dynamics, altering pressure and circulation, improving blood flow and hair growth.

This study reported that in rat retinas under high pressure, allopregnanolone synthesis increased and helped reduce pressure-induced damage through GABAA receptors, suggesting potential therapeutic use in glaucoma.

This study suggests that in an ex vivo rat glaucoma model, TSPO activation is involved in Allopregnanolone synthesis and may help prevent retinal damage, with TSPO agonists as potential therapeutic agents.

The researchers presented a rare case of a four-year-old developing scarring alopecia after a two-week ICU stay, highlighting the challenge of diagnosing pressure alopecia in children and the crucial role of early detection and trichoscopy in preventing permanent hair loss.