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GlossaryWnt signaling pathway (canonical Wnt signaling)

regulates cell growth and differentiation, crucial for hair regeneration

The Wnt signaling pathway is a complex network of proteins that play a crucial role in regulating cell growth, development, and differentiation. It is particularly important in the context of hair growth and regeneration, as it influences the activity of hair follicle stem cells. Dysregulation of this pathway can lead to conditions like alopecia or other hair growth disorders.

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Wnt4 Increases the Thickness of the Epidermis in Burn Wounds by Activating Canonical Wnt Signalling and Decreasing Cell Junctions Between Epidermal Cells

research Wnt4 Increases the Thickness of the Epidermis in Burn Wounds by Activating Canonical Wnt Signalling and Decreasing Cell Junctions Between Epidermal Cells

1 citations, January 2023 in “Burns & Trauma”

Wnt4 protein makes the outer skin layer thicker in burn wounds by turning on a specific healing pathway and loosening the connections between skin cells.

research Potential Relationship Between the Canonical Wnt Signaling Pathway and Expression of the Vitamin D Receptor in Alopecia

21 citations, March 2014 in “Clinical and experimental dermatology”

Targeting the Wnt pathway might help treat hair loss.

Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia

research Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia

95 citations, May 2012 in “British Journal of Dermatology”

Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.

research Transgenic Flash Mice for In Vivo Quantitative Monitoring of Canonical Wnt Signaling to Track Hair Follicle Cycle Dynamics

16 citations, February 2014 in “Journal of Investigative Dermatology”

Researchers developed a mouse model that tracks hair growth using bioluminescence, improving accuracy in studying hair cycles.

research Canonical and Non-Canonical Wnt Signaling Control the Regeneration of Amputated Rodent Vibrissae Follicles

5 citations, January 2016 in “Journal of Molecular Histology”

Both main and alternative Wnt signaling are important for regrowing rodent whisker follicles.

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community The Real Cause Of Androgenetic Alopecia

in Research/Science 676 upvotes 3 months ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community JW Pharmaceutical shows superiority of 'JW0061' in hair growth over existing treatments in US

in Research/Science 99 upvotes 8 months ago

JW0061 shows superior hair growth results compared to existing treatments, with significant increases in hair follicles. The Wnt/β-catenin pathway is crucial for hair growth, and JW0061 activates this pathway effectively.

community Back again with a 17 month update. (Fin/Min doing the heavy lifting, occasional 0.5mm microneedling, and Nizoral for scalp health) - Angles are not identical but whatever - Expecting and hoping to be back to pre-hairloss hairline within 6 months from now.

in Progress Pictures 394 upvotes 11 months ago

The conversation is about a user's 17-month progress in treating hair loss using finasteride, minoxidil, occasional 0.5mm microneedling, and Nizoral. The user reports significant hairline recovery and aims to achieve a pre-hair loss hairline within the next 6 months.

community Seems like good progress... Happy with it so far

in Progress Pictures 216 upvotes 1 year ago

The user "Segggs" shared their progress with hair loss treatments including 6 months of foam minoxidil, 3 months of finasteride, keto shampoo, and inconsistent microneedling. The replies were positive, with some users commenting on the regrowth in the temple area.

community [20M]What 8 months of no progress looks and feels like on fin/min/derma.

in Finasteride/Dutasteride 8 upvotes 9 months ago

A 20-year-old has seen no improvement in hair loss after 8 months using finasteride, minoxidil, topical solutions, and microneedling. They express frustration and a loss of confidence due to the lack of results.

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